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Antiretroviral therapy and management of HIV infection

Summary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of H... Full description

Journal Title: The Lancet (British edition) 2010, Vol.376 (9734), p.49-62
Main Author: Volberding, Paul A, Prof
Other Authors: Deeks, Steven G, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
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title: Antiretroviral therapy and management of HIV infection
format: Article
creator:
  • Volberding, Paul A, Prof
  • Deeks, Steven G, Prof
subjects:
  • Abridged Index Medicus
  • Acquired immune deficiency syndrome
  • AIDS
  • Anti-Retroviral Agents - adverse effects
  • Anti-Retroviral Agents - therapeutic use
  • Antibiotics. Antiinfectious agents. Antiparasitic agents
  • Antiretroviral drugs
  • Antiviral agents
  • Biological and medical sciences
  • Bone
  • Clinical medicine
  • Drug Resistance, Viral
  • Drug therapy
  • Epidemiology
  • Family medical history
  • General aspects
  • Health aspects
  • Highly active antiretroviral therapy
  • HIV
  • HIV infection
  • HIV Infections - complications
  • HIV Infections - drug therapy
  • HIV Infections - physiopathology
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Infectious diseases
  • Internal Medicine
  • Medical sciences
  • Mortality
  • Pathogenesis
  • Pharmacology. Drug treatments
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
ispartof: The Lancet (British edition), 2010, Vol.376 (9734), p.49-62
description: Summary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of HIV replication. Despite the unquestioned success of antiretroviral therapy, limitations persist. Treatment success needs strict lifelong drug adherence. Although the widely used drugs are generally well tolerated, most have some short-term toxic effects and all have the potential for both known and unknown long-term toxic effects. Drug and administration costs limit treatment in resource-poor regions, and are a growing concern even in resource rich settings. Finally, complete or near complete control of viral replication does not fully restore health. Long-term treated patients who are on an otherwise effective regimen often show persistent immune dysfunction and have higher than expected risk for various non-AIDS-related complications, including heart, bone, liver, kidney, and neurocognitive diseases.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionSummary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of HIV replication. Despite the unquestioned success of antiretroviral therapy, limitations persist. Treatment success needs strict lifelong drug adherence. Although the widely used drugs are generally well tolerated, most have some short-term toxic effects and all have the potential for both known and unknown long-term toxic effects. Drug and administration costs limit treatment in resource-poor regions, and are a growing concern even in resource rich settings. Finally, complete or near complete control of viral replication does not fully restore health. Long-term treated patients who are on an otherwise effective regimen often show persistent immune dysfunction and have higher than expected risk for various non-AIDS-related complications, including heart, bone, liver, kidney, and neurocognitive diseases.
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subjectAbridged Index Medicus ; Acquired immune deficiency syndrome ; AIDS ; Anti-Retroviral Agents - adverse effects ; Anti-Retroviral Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral drugs ; Antiviral agents ; Biological and medical sciences ; Bone ; Clinical medicine ; Drug Resistance, Viral ; Drug therapy ; Epidemiology ; Family medical history ; General aspects ; Health aspects ; Highly active antiretroviral therapy ; HIV ; HIV infection ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Internal Medicine ; Medical sciences ; Mortality ; Pathogenesis ; Pharmacology. Drug treatments ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
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descriptionSummary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of HIV replication. Despite the unquestioned success of antiretroviral therapy, limitations persist. Treatment success needs strict lifelong drug adherence. Although the widely used drugs are generally well tolerated, most have some short-term toxic effects and all have the potential for both known and unknown long-term toxic effects. Drug and administration costs limit treatment in resource-poor regions, and are a growing concern even in resource rich settings. Finally, complete or near complete control of viral replication does not fully restore health. Long-term treated patients who are on an otherwise effective regimen often show persistent immune dysfunction and have higher than expected risk for various non-AIDS-related complications, including heart, bone, liver, kidney, and neurocognitive diseases.
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5Antibiotics. Antiinfectious agents. Antiparasitic agents
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8Biological and medical sciences
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13Epidemiology
14Family medical history
15General aspects
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19HIV infection
20HIV Infections - complications
21HIV Infections - drug therapy
22HIV Infections - physiopathology
23Human immunodeficiency virus
24Human viral diseases
25Humans
26Infectious diseases
27Internal Medicine
28Medical sciences
29Mortality
30Pathogenesis
31Pharmacology. Drug treatments
32Viral diseases
33Viral diseases of the lymphoid tissue and the blood. Aids
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1Deeks, Steven G, Prof
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abstractSummary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of HIV replication. Despite the unquestioned success of antiretroviral therapy, limitations persist. Treatment success needs strict lifelong drug adherence. Although the widely used drugs are generally well tolerated, most have some short-term toxic effects and all have the potential for both known and unknown long-term toxic effects. Drug and administration costs limit treatment in resource-poor regions, and are a growing concern even in resource rich settings. Finally, complete or near complete control of viral replication does not fully restore health. Long-term treated patients who are on an otherwise effective regimen often show persistent immune dysfunction and have higher than expected risk for various non-AIDS-related complications, including heart, bone, liver, kidney, and neurocognitive diseases.
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pubElsevier Ltd
pmid20609987
doi10.1016/S0140-6736(10)60676-9