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A small-molecule screen identifies new functions for the plant hormone strigolactone

Parasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this... Full description

Journal Title: Nature chemical biology 2010-10, Vol.6 (10), p.741-749
Main Author: McCourt, Peter
Other Authors: Tsuchiya, Yuichiro , Vidaurre, Danielle , Toh, Shigeo , Hanada, Atsushi , Nambara, Eiji , Kamiya, Yuji , Yamaguchi, Shinjiro
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Nature Publishing Group
ID: ISSN: 1552-4450
Link: https://www.ncbi.nlm.nih.gov/pubmed/20818397
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title: A small-molecule screen identifies new functions for the plant hormone strigolactone
format: Article
creator:
  • McCourt, Peter
  • Tsuchiya, Yuichiro
  • Vidaurre, Danielle
  • Toh, Shigeo
  • Hanada, Atsushi
  • Nambara, Eiji
  • Kamiya, Yuji
  • Yamaguchi, Shinjiro
subjects:
  • Active Transport, Cell Nucleus - drug effects
  • Arabidopsis - drug effects
  • Arabidopsis - genetics
  • Arabidopsis - growth & development
  • Arabidopsis - metabolism
  • Arabidopsis Proteins - metabolism
  • Basic-Leucine Zipper Transcription Factors - metabolism
  • Biochemistry
  • Chemical compounds
  • Genotype
  • Germination - drug effects
  • Hormones
  • Hypocotyl - drug effects
  • Hypocotyl - genetics
  • Hypocotyl - growth & development
  • Lactones - analysis
  • Lactones - chemistry
  • Lactones - metabolism
  • Lactones - pharmacology
  • Light
  • Molecular biology
  • Nuclear Proteins - metabolism
  • Plant Growth Regulators - analysis
  • Plant Growth Regulators - chemistry
  • Plant Growth Regulators - metabolism
  • Plant Growth Regulators - pharmacology
  • Seedlings - drug effects
  • Seedlings - growth & development
  • Seedlings - metabolism
  • Seedlings - radiation effects
  • Small Molecule Libraries - chemistry
  • Ubiquitin-Conjugating Enzymes - metabolism
  • Weeds
ispartof: Nature chemical biology, 2010-10, Vol.6 (10), p.741-749
description: Parasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using Arabidopsis thaliana as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1552-4450
fulltext: fulltext
issn:
  • 1552-4450
  • 1552-4469
url: Link


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descriptionParasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using Arabidopsis thaliana as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed.
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subjectActive Transport, Cell Nucleus - drug effects ; Arabidopsis - drug effects ; Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis - metabolism ; Arabidopsis Proteins - metabolism ; Basic-Leucine Zipper Transcription Factors - metabolism ; Biochemistry ; Chemical compounds ; Genotype ; Germination - drug effects ; Hormones ; Hypocotyl - drug effects ; Hypocotyl - genetics ; Hypocotyl - growth & development ; Lactones - analysis ; Lactones - chemistry ; Lactones - metabolism ; Lactones - pharmacology ; Light ; Molecular biology ; Nuclear Proteins - metabolism ; Plant Growth Regulators - analysis ; Plant Growth Regulators - chemistry ; Plant Growth Regulators - metabolism ; Plant Growth Regulators - pharmacology ; Seedlings - drug effects ; Seedlings - growth & development ; Seedlings - metabolism ; Seedlings - radiation effects ; Small Molecule Libraries - chemistry ; Ubiquitin-Conjugating Enzymes - metabolism ; Weeds
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abstractParasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using Arabidopsis thaliana as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed.
copUnited States
pubNature Publishing Group
pmid20818397
doi10.1038/nchembio.435