Intake of trans fatty acids and risk of coronary heart disease among women

Journal Title:	The Lancet (British edition) 1993, Vol.341 (8845), p.581-585
Main Author:	Willett, W.C
Other Authors:	Stampfer, M.J , Manson, J.E , Colditz, G.A , Speizer, F.E , Rosner, B.A , Hennekens, C.H , Hennekens, C.H , Willett, W.C , Stampfer, M.J , Colditz, G.A , Willett, W.C , Sampson, L.A , Rosner, B.A
Format:	Electronic Article
Language:	English
Subjects:	Abridged Index Medicus Acids Age Factors Biological and medical sciences Body Mass Index Cardiology. Vascular system Cardiovascular disease Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Cohort Studies Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - etiology Coronary heart disease Diet Surveys Energy Intake Energy Metabolism Exercise Fatty acids Fatty Acids, Unsaturated - adverse effects Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - chemistry Female Health aspects Heart Humans Hydrogenation Hypertension - complications Margarine Margarine - adverse effects Margarine - analysis Medical sciences Nurses Oils & fats Proportional Hazards Models Risk Factors Smoking - adverse effects Stereoisomerism United States - epidemiology Vegetable oils Vitamins - therapeutic use Women
Quelle:	Alma/SFX Local Collection
Publisher:	London: Elsevier Ltd
ID:	ISSN: 0140-6736
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title:	Intake of trans fatty acids and risk of coronary heart disease among women
format:	Article
creator:	Willett, W.C Stampfer, M.J Manson, J.E Colditz, G.A Speizer, F.E Rosner, B.A Hennekens, C.H Hennekens, C.H Willett, W.C Stampfer, M.J Colditz, G.A Willett, W.C Sampson, L.A Rosner, B.A
subjects:	Abridged Index Medicus Acids Age Factors Biological and medical sciences Body Mass Index Cardiology. Vascular system Cardiovascular disease Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Cohort Studies Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - etiology Coronary heart disease Diet Surveys Energy Intake Energy Metabolism Exercise Fatty acids Fatty Acids, Unsaturated - adverse effects Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - chemistry Female Health aspects Heart Humans Hydrogenation Hypertension - complications Margarine Margarine - adverse effects Margarine - analysis Medical sciences Nurses Oils & fats Proportional Hazards Models Risk Factors Smoking - adverse effects Stereoisomerism United States - epidemiology Vegetable oils Vitamins - therapeutic use Women
ispartof:	The Lancet (British edition), 1993, Vol.341 (8845), p.581-585
description:	Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.
language:	eng
source:	Alma/SFX Local Collection
identifier:	ISSN: 0140-6736
fulltext:	fulltext
issn:	0140-6736 1474-547X
url:	Link

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Intake of trans fatty acids and risk of coronary heart disease among women

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Willett, W.C ; Stampfer, M.J ; Manson, J.E ; Colditz, G.A ; Speizer, F.E ; Rosner, B.A ; Hennekens, C.H ; Hennekens, C.H ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Willett, W.C ; Sampson, L.A ; Rosner, B.A

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description

Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.

identifier

0	ISSN: 0140-6736
1	EISSN: 1474-547X
2	DOI: 10.1016/0140-6736(93)90350-P
3	PMID: 8094827
4	CODEN: LANCAO

language

eng

publisher

London: Elsevier Ltd

subject

Abridged Index Medicus ; Acids ; Age Factors ; Biological and medical sciences ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular disease ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cohort Studies ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary heart disease ; Diet Surveys ; Energy Intake ; Energy Metabolism ; Exercise ; Fatty acids ; Fatty Acids, Unsaturated - adverse effects ; Fatty Acids, Unsaturated - analysis ; Fatty Acids, Unsaturated - chemistry ; Female ; Health aspects ; Heart ; Humans ; Hydrogenation ; Hypertension - complications ; Margarine ; Margarine - adverse effects ; Margarine - analysis ; Medical sciences ; Nurses ; Oils & fats ; Proportional Hazards Models ; Risk Factors ; Smoking - adverse effects ; Stereoisomerism ; United States - epidemiology ; Vegetable oils ; Vitamins - therapeutic use ; Women

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The Lancet (British edition), 1993, Vol.341 (8845), p.581-585

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2	COPYRIGHT 1993 Elsevier B.V.
3	Copyright Lancet Ltd. Mar 6, 1993

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1	Stampfer, M.J
2	Manson, J.E
3	Colditz, G.A
4	Speizer, F.E
5	Rosner, B.A
6	Hennekens, C.H
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9	Stampfer, M.J
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11	Willett, W.C
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title

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creationdate	1993
title	Intake of trans fatty acids and risk of coronary heart disease among women
author	Willett, W.C ; Stampfer, M.J ; Manson, J.E ; Colditz, G.A ; Speizer, F.E ; Rosner, B.A ; Hennekens, C.H ; Hennekens, C.H ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Willett, W.C ; Sampson, L.A ; Rosner, B.A

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6	Cardiovascular disease
7	Cholesterol
8	Cholesterol, HDL - blood
9	Cholesterol, LDL - blood
10	Cohort Studies
11	Coronary Disease - blood
12	Coronary Disease - epidemiology
13	Coronary Disease - etiology
14	Coronary heart disease
15	Diet Surveys
16	Energy Intake
17	Energy Metabolism
18	Exercise
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20	Fatty Acids, Unsaturated - adverse effects
21	Fatty Acids, Unsaturated - analysis
22	Fatty Acids, Unsaturated - chemistry
23	Female
24	Health aspects
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26	Humans
27	Hydrogenation
28	Hypertension - complications
29	Margarine
30	Margarine - adverse effects
31	Margarine - analysis
32	Medical sciences
33	Nurses
34	Oils & fats
35	Proportional Hazards Models
36	Risk Factors
37	Smoking - adverse effects
38	Stereoisomerism
39	United States - epidemiology
40	Vegetable oils
41	Vitamins - therapeutic use
42	Women

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0	Willett, W.C
1	Stampfer, M.J
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3	Colditz, G.A
4	Speizer, F.E
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0	Willett, W.C
1	Stampfer, M.J
2	Manson, J.E
3	Colditz, G.A
4	Speizer, F.E
5	Rosner, B.A
6	Hennekens, C.H
7	Hennekens, C.H
8	Willett, W.C
9	Stampfer, M.J
10	Colditz, G.A
11	Willett, W.C
12	Sampson, L.A
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Intake of trans fatty acids and risk of coronary heart disease among women

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The Lancet (British edition)

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Lancet

date

1993

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341

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abstract

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London

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Elsevier Ltd

pmid

8094827

doi

10.1016/0140-6736(93)90350-P

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Intake of trans fatty acids and risk of coronary heart disease among women