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Intake of trans fatty acids and risk of coronary heart disease among women

Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart dise... Full description

Journal Title: The Lancet (British edition) 1993, Vol.341 (8845), p.581-585
Main Author: Willett, W.C
Other Authors: Stampfer, M.J , Manson, J.E , Colditz, G.A , Speizer, F.E , Rosner, B.A , Hennekens, C.H , Hennekens, C.H , Willett, W.C , Stampfer, M.J , Colditz, G.A , Willett, W.C , Sampson, L.A , Rosner, B.A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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title: Intake of trans fatty acids and risk of coronary heart disease among women
format: Article
creator:
  • Willett, W.C
  • Stampfer, M.J
  • Manson, J.E
  • Colditz, G.A
  • Speizer, F.E
  • Rosner, B.A
  • Hennekens, C.H
  • Hennekens, C.H
  • Willett, W.C
  • Stampfer, M.J
  • Colditz, G.A
  • Willett, W.C
  • Sampson, L.A
  • Rosner, B.A
subjects:
  • Abridged Index Medicus
  • Acids
  • Age Factors
  • Biological and medical sciences
  • Body Mass Index
  • Cardiology. Vascular system
  • Cardiovascular disease
  • Cholesterol
  • Cholesterol, HDL - blood
  • Cholesterol, LDL - blood
  • Cohort Studies
  • Coronary Disease - blood
  • Coronary Disease - epidemiology
  • Coronary Disease - etiology
  • Coronary heart disease
  • Diet Surveys
  • Energy Intake
  • Energy Metabolism
  • Exercise
  • Fatty acids
  • Fatty Acids, Unsaturated - adverse effects
  • Fatty Acids, Unsaturated - analysis
  • Fatty Acids, Unsaturated - chemistry
  • Female
  • Health aspects
  • Heart
  • Humans
  • Hydrogenation
  • Hypertension - complications
  • Margarine
  • Margarine - adverse effects
  • Margarine - analysis
  • Medical sciences
  • Nurses
  • Oils & fats
  • Proportional Hazards Models
  • Risk Factors
  • Smoking - adverse effects
  • Stereoisomerism
  • United States - epidemiology
  • Vegetable oils
  • Vitamins - therapeutic use
  • Women
ispartof: The Lancet (British edition), 1993, Vol.341 (8845), p.581-585
description: Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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titleIntake of trans fatty acids and risk of coronary heart disease among women
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creatorWillett, W.C ; Stampfer, M.J ; Manson, J.E ; Colditz, G.A ; Speizer, F.E ; Rosner, B.A ; Hennekens, C.H ; Hennekens, C.H ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Willett, W.C ; Sampson, L.A ; Rosner, B.A
creatorcontribWillett, W.C ; Stampfer, M.J ; Manson, J.E ; Colditz, G.A ; Speizer, F.E ; Rosner, B.A ; Hennekens, C.H ; Hennekens, C.H ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Willett, W.C ; Sampson, L.A ; Rosner, B.A
descriptionTrans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.
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subjectAbridged Index Medicus ; Acids ; Age Factors ; Biological and medical sciences ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular disease ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cohort Studies ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary heart disease ; Diet Surveys ; Energy Intake ; Energy Metabolism ; Exercise ; Fatty acids ; Fatty Acids, Unsaturated - adverse effects ; Fatty Acids, Unsaturated - analysis ; Fatty Acids, Unsaturated - chemistry ; Female ; Health aspects ; Heart ; Humans ; Hydrogenation ; Hypertension - complications ; Margarine ; Margarine - adverse effects ; Margarine - analysis ; Medical sciences ; Nurses ; Oils & fats ; Proportional Hazards Models ; Risk Factors ; Smoking - adverse effects ; Stereoisomerism ; United States - epidemiology ; Vegetable oils ; Vitamins - therapeutic use ; Women
ispartofThe Lancet (British edition), 1993, Vol.341 (8845), p.581-585
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8Willett, W.C
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11Willett, W.C
12Sampson, L.A
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title
0Intake of trans fatty acids and risk of coronary heart disease among women
1The Lancet (British edition)
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descriptionTrans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.
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0Abridged Index Medicus
1Acids
2Age Factors
3Biological and medical sciences
4Body Mass Index
5Cardiology. Vascular system
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7Cholesterol
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17Energy Metabolism
18Exercise
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20Fatty Acids, Unsaturated - adverse effects
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24Health aspects
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26Humans
27Hydrogenation
28Hypertension - complications
29Margarine
30Margarine - adverse effects
31Margarine - analysis
32Medical sciences
33Nurses
34Oils & fats
35Proportional Hazards Models
36Risk Factors
37Smoking - adverse effects
38Stereoisomerism
39United States - epidemiology
40Vegetable oils
41Vitamins - therapeutic use
42Women
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titleIntake of trans fatty acids and risk of coronary heart disease among women
authorWillett, W.C ; Stampfer, M.J ; Manson, J.E ; Colditz, G.A ; Speizer, F.E ; Rosner, B.A ; Hennekens, C.H ; Hennekens, C.H ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Willett, W.C ; Sampson, L.A ; Rosner, B.A
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1Acids
2Age Factors
3Biological and medical sciences
4Body Mass Index
5Cardiology. Vascular system
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7Cholesterol
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38Stereoisomerism
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abstractTrans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% Cl 1·12-2·00], p for trend = 0·001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1·67 [1·05-2·66], p for trend = 0·002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.
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pmid8094827
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