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Evolutionary constraints and the neutral theory

The neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate... Full description

Journal Title: Journal of molecular evolution 1984-01-01, Vol.21 (1 19), p.90-92
Main Author: Jukes, T. H.
Other Authors: Kimura, M.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Legacy CDMS
ID: ISSN: 0022-2844
Link: https://www.ncbi.nlm.nih.gov/pubmed/6442364
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title: Evolutionary constraints and the neutral theory
format: Article
creator:
  • Jukes, T. H.
  • Kimura, M.
subjects:
  • Animals
  • Base Sequence
  • Biological Evolution
  • Codon - genetics
  • DNA - genetics
  • LIFE SCIENCES (GENERAL)
  • Models, Genetic
  • Mutation
  • Space life sciences
ispartof: Journal of molecular evolution, 1984-01-01, Vol.21 (1 19), p.90-92
description: The neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate in globin pseudogenes is about 5 x 10 to the -9th substitutions per site per year in mammals. Rates slower than this indicate the presence of constraints imposed by negative (natural) selection, which rejects and discards deleterious mutations.
language: eng
source:
identifier: ISSN: 0022-2844
fulltext: no_fulltext
issn:
  • 0022-2844
  • 1432-1432
url: Link


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descriptionThe neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate in globin pseudogenes is about 5 x 10 to the -9th substitutions per site per year in mammals. Rates slower than this indicate the presence of constraints imposed by negative (natural) selection, which rejects and discards deleterious mutations.
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subjectAnimals ; Base Sequence ; Biological Evolution ; Codon - genetics ; DNA - genetics ; LIFE SCIENCES (GENERAL) ; Models, Genetic ; Mutation ; Space life sciences
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descriptionThe neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate in globin pseudogenes is about 5 x 10 to the -9th substitutions per site per year in mammals. Rates slower than this indicate the presence of constraints imposed by negative (natural) selection, which rejects and discards deleterious mutations.
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abstractThe neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate in globin pseudogenes is about 5 x 10 to the -9th substitutions per site per year in mammals. Rates slower than this indicate the presence of constraints imposed by negative (natural) selection, which rejects and discards deleterious mutations.
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pmid6442364
doi10.1007/BF02100633