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Cytokines and CNS Development

Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia... Full description

Journal Title: Neuron 2009, Vol.64 (1), p.61-78
Main Author: Deverman, Benjamin E
Other Authors: Patterson, Paul H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/19840550
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title: Cytokines and CNS Development
format: Article
creator:
  • Deverman, Benjamin E
  • Patterson, Paul H
subjects:
  • Animals
  • Brain - embryology
  • Brain - growth & development
  • Brain - physiology
  • Cell culture
  • Cell division
  • Cytokines
  • Cytokines - metabolism
  • Humans
  • Infections
  • Models, Neurological
  • Neuroglia - physiology
  • Neurons
  • Neurons - physiology
  • Neuroscience(all)
  • Spinal Cord - embryology
  • Spinal Cord - growth & development
  • Spinal Cord - physiology
  • Stem cells
ispartof: Neuron, 2009, Vol.64 (1), p.61-78
description: Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly impact fetal neurodevelopment. The neurodevelopmental roles of individual cytokine signaling pathways are being elucidated through gain- and loss-of-function studies in cell culture and model organisms. We review this work with a particular emphasis on studies where cytokines, their receptors, or components of their signaling pathways have been altered in vivo. The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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descriptionCytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly impact fetal neurodevelopment. The neurodevelopmental roles of individual cytokine signaling pathways are being elucidated through gain- and loss-of-function studies in cell culture and model organisms. We review this work with a particular emphasis on studies where cytokines, their receptors, or components of their signaling pathways have been altered in vivo. The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.
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subjectAnimals ; Brain - embryology ; Brain - growth & development ; Brain - physiology ; Cell culture ; Cell division ; Cytokines ; Cytokines - metabolism ; Humans ; Infections ; Models, Neurological ; Neuroglia - physiology ; Neurons ; Neurons - physiology ; Neuroscience(all) ; Spinal Cord - embryology ; Spinal Cord - growth & development ; Spinal Cord - physiology ; Stem cells
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abstractCytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly impact fetal neurodevelopment. The neurodevelopmental roles of individual cytokine signaling pathways are being elucidated through gain- and loss-of-function studies in cell culture and model organisms. We review this work with a particular emphasis on studies where cytokines, their receptors, or components of their signaling pathways have been altered in vivo. The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.
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