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Phosphorothioation of DNA in bacteria by dnd genes

Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorot... Full description

Journal Title: Nature chemical biology 2007-11, Vol.3 (11), p.709-710
Main Author: Deng, Zixin
Other Authors: Dedon, Peter C , Wang, Lianrong , Chen, Shi , Xu, Tiegang , Taghizadeh, Koli , Wishnok, John S , Zhou, Xiufen , You, Delin
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
RNA
Quelle: Alma/SFX Local Collection
Publisher: United States: Nature Publishing Group
ID: ISSN: 1552-4450
Link: https://www.ncbi.nlm.nih.gov/pubmed/17934475
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title: Phosphorothioation of DNA in bacteria by dnd genes
format: Article
creator:
  • Deng, Zixin
  • Dedon, Peter C
  • Wang, Lianrong
  • Chen, Shi
  • Xu, Tiegang
  • Taghizadeh, Koli
  • Wishnok, John S
  • Zhou, Xiufen
  • You, Delin
subjects:
  • Bacteria
  • Biochemistry
  • Cellular biology
  • Deoxyribonucleic acid
  • DNA
  • DNA biosynthesis
  • DNA, Bacterial - metabolism
  • Escherichia coli - genetics
  • Escherichia coli - metabolism
  • Genes, Bacterial - genetics
  • Genetics
  • Mass Spectrometry
  • Molecular Structure
  • Multigene Family - genetics
  • Nucleotide sequence
  • phosphorothioate
  • Phosphorylation
  • Replication
  • Ribonucleic acid
  • RNA
  • RNA modification
  • Streptomyces lividans - genetics
  • Streptomyces lividans - metabolism
  • Sulfhydryl Compounds - chemistry
  • Sulfhydryl Compounds - metabolism
  • Sulfur
  • Transcription
  • Translation
ispartof: Nature chemical biology, 2007-11, Vol.3 (11), p.709-710
description: Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1552-4450
fulltext: fulltext
issn:
  • 1552-4450
  • 1552-4469
url: Link


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descriptionModifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
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subjectBacteria ; Biochemistry ; Cellular biology ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; DNA, Bacterial - metabolism ; Escherichia coli - genetics ; Escherichia coli - metabolism ; Genes, Bacterial - genetics ; Genetics ; Mass Spectrometry ; Molecular Structure ; Multigene Family - genetics ; Nucleotide sequence ; phosphorothioate ; Phosphorylation ; Replication ; Ribonucleic acid ; RNA ; RNA modification ; Streptomyces lividans - genetics ; Streptomyces lividans - metabolism ; Sulfhydryl Compounds - chemistry ; Sulfhydryl Compounds - metabolism ; Sulfur ; Transcription ; Translation
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abstractModifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
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pmid17934475
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