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Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment

Cholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study d... Full description

Journal Title: Diabetologia 1994, Vol.37 (8), p.773-780
Main Author: GYLLING, H
Other Authors: MIETTINEN, T. A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin: Springer
ID: ISSN: 0012-186X
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recordid: cdi_proquest_miscellaneous_76875690
title: Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
format: Article
creator:
  • GYLLING, H
  • MIETTINEN, T. A
subjects:
  • Apolipoproteins A - blood
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Body Mass Index
  • Brassica
  • Cholesterol - blood
  • Cholesterol - metabolism
  • Cholesterol, Dietary
  • Cholesterol, HDL - blood
  • Cholesterol, LDL - blood
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - metabolism
  • Diabetes. Impaired glucose tolerance
  • Double-Blind Method
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Energy Intake
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty Acids, Monounsaturated
  • Glycated Hemoglobin A - analysis
  • Humans
  • Hypercholesterolemia - complications
  • Hypercholesterolemia - metabolism
  • Hypercholesterolemia - therapy
  • Lipoproteins - blood
  • Male
  • Margarine
  • Medical sciences
  • Middle Aged
  • Phospholipids - blood
  • Plant Oils
  • Rapeseed Oil
  • Sialic Acids - blood
  • Sitosterols - administration & dosage
  • Sitosterols - therapeutic use
  • Triglycerides - blood
  • Vitamin E - blood
ispartof: Diabetologia, 1994, Vol.37 (8), p.773-780
description: Cholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6 +/- 2, 12 +/- 6, 9 +/- 3 and 6 +/- 2%, mean +/- SEM, and HDL cholesterol was increased by 11 +/- 4% (p < 0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037-1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein A I, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25 +/- 2 to 9 +/- 2% (p < 0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleSerum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
creatorGYLLING, H ; MIETTINEN, T. A
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descriptionCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6 +/- 2, 12 +/- 6, 9 +/- 3 and 6 +/- 2%, mean +/- SEM, and HDL cholesterol was increased by 11 +/- 4% (p < 0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037-1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein A I, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25 +/- 2 to 9 +/- 2% (p < 0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
identifier
0ISSN: 0012-186X
1EISSN: 1432-0428
2DOI: 10.1007/BF00404334
3PMID: 7988779
languageeng
publisherBerlin: Springer
subjectApolipoproteins A - blood ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Brassica ; Cholesterol - blood ; Cholesterol - metabolism ; Cholesterol, Dietary ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Over Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Intake ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Monounsaturated ; Glycated Hemoglobin A - analysis ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - metabolism ; Hypercholesterolemia - therapy ; Lipoproteins - blood ; Male ; Margarine ; Medical sciences ; Middle Aged ; Phospholipids - blood ; Plant Oils ; Rapeseed Oil ; Sialic Acids - blood ; Sitosterols - administration & dosage ; Sitosterols - therapeutic use ; Triglycerides - blood ; Vitamin E - blood
ispartofDiabetologia, 1994, Vol.37 (8), p.773-780
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1MIETTINEN, T. A
title
0Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
1Diabetologia
addtitleDiabetologia
descriptionCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6 +/- 2, 12 +/- 6, 9 +/- 3 and 6 +/- 2%, mean +/- SEM, and HDL cholesterol was increased by 11 +/- 4% (p < 0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037-1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein A I, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25 +/- 2 to 9 +/- 2% (p < 0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
subject
0Apolipoproteins A - blood
1Biological and medical sciences
2Blood Glucose - metabolism
3Body Mass Index
4Brassica
5Cholesterol - blood
6Cholesterol - metabolism
7Cholesterol, Dietary
8Cholesterol, HDL - blood
9Cholesterol, LDL - blood
10Cross-Over Studies
11Diabetes Mellitus, Type 2 - complications
12Diabetes Mellitus, Type 2 - metabolism
13Diabetes. Impaired glucose tolerance
14Double-Blind Method
15Endocrine pancreas. Apud cells (diseases)
16Endocrinopathies
17Energy Intake
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Acids, Monounsaturated
20Glycated Hemoglobin A - analysis
21Humans
22Hypercholesterolemia - complications
23Hypercholesterolemia - metabolism
24Hypercholesterolemia - therapy
25Lipoproteins - blood
26Male
27Margarine
28Medical sciences
29Middle Aged
30Phospholipids - blood
31Plant Oils
32Rapeseed Oil
33Sialic Acids - blood
34Sitosterols - administration & dosage
35Sitosterols - therapeutic use
36Triglycerides - blood
37Vitamin E - blood
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authorGYLLING, H ; MIETTINEN, T. A
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0Apolipoproteins A - blood
1Biological and medical sciences
2Blood Glucose - metabolism
3Body Mass Index
4Brassica
5Cholesterol - blood
6Cholesterol - metabolism
7Cholesterol, Dietary
8Cholesterol, HDL - blood
9Cholesterol, LDL - blood
10Cross-Over Studies
11Diabetes Mellitus, Type 2 - complications
12Diabetes Mellitus, Type 2 - metabolism
13Diabetes. Impaired glucose tolerance
14Double-Blind Method
15Endocrine pancreas. Apud cells (diseases)
16Endocrinopathies
17Energy Intake
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Acids, Monounsaturated
20Glycated Hemoglobin A - analysis
21Humans
22Hypercholesterolemia - complications
23Hypercholesterolemia - metabolism
24Hypercholesterolemia - therapy
25Lipoproteins - blood
26Male
27Margarine
28Medical sciences
29Middle Aged
30Phospholipids - blood
31Plant Oils
32Rapeseed Oil
33Sialic Acids - blood
34Sitosterols - administration & dosage
35Sitosterols - therapeutic use
36Triglycerides - blood
37Vitamin E - blood
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abstractCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6 +/- 2, 12 +/- 6, 9 +/- 3 and 6 +/- 2%, mean +/- SEM, and HDL cholesterol was increased by 11 +/- 4% (p < 0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037-1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein A I, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25 +/- 2 to 9 +/- 2% (p < 0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
copBerlin
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pmid7988779
doi10.1007/BF00404334