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An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using logistic regression analysis

Antioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption a... Full description

Journal Title: Journal of clinical epidemiology 1995, Vol.48 (2), p.307-316
Main Author: Todd, Susan
Other Authors: Woodward, Mark , Bolton-Smith, Caroline
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0895-4356
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title: An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using logistic regression analysis
format: Article
creator:
  • Todd, Susan
  • Woodward, Mark
  • Bolton-Smith, Caroline
subjects:
  • Adult
  • Antioxidant vitamins
  • Antioxidants - administration & dosage
  • Biological and medical sciences
  • Blood pressure
  • Cardiology. Vascular system
  • Cholesterol
  • Confounding Factors (Epidemiology)
  • Coronary Disease - epidemiology
  • Coronary Disease - prevention & control
  • Coronary heart disease
  • Coronary heart disease risk factors
  • Female
  • Food frequency questionnaire
  • Heart
  • Humans
  • Logistic Models
  • Male
  • Medical sciences
  • Middle Aged
  • Odds Ratio
  • Scotland - epidemiology
  • Smoking
  • Surveys and Questionnaires
  • Vitamins - administration & dosage
ispartof: Journal of clinical epidemiology, 1995, Vol.48 (2), p.307-316
description: Antioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption and prevalent coronary heart disease (CHD), analysing diagnosed and undiagnosed cases separately. For men, there is a protective effect of all three antioxidants, before and after adjustment for a comprehensive set of confounding variables. For women the picture is less clear, only vitamin C is negatively associated with CHD, but the effect is removed by adjustment. The logistic regression model is also used to determine classification rules for deciding whether or not an individual has CHD. The classification error rates using the antioxidants are found to be very similar to those found using smoking, blood pressure and serum total cholesterol as classification variables. Significant interactions are found for the antioxidants with smoking, cholesterol and age. It is concluded that antioxidant vitamin intake protects against CHD for men. Logistic regression analysis is compared with discriminant analysis, and is found to have important advantages as an epidemiological tool.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0895-4356
fulltext: fulltext
issn:
  • 0895-4356
  • 1878-5921
url: Link


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descriptionAntioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption and prevalent coronary heart disease (CHD), analysing diagnosed and undiagnosed cases separately. For men, there is a protective effect of all three antioxidants, before and after adjustment for a comprehensive set of confounding variables. For women the picture is less clear, only vitamin C is negatively associated with CHD, but the effect is removed by adjustment. The logistic regression model is also used to determine classification rules for deciding whether or not an individual has CHD. The classification error rates using the antioxidants are found to be very similar to those found using smoking, blood pressure and serum total cholesterol as classification variables. Significant interactions are found for the antioxidants with smoking, cholesterol and age. It is concluded that antioxidant vitamin intake protects against CHD for men. Logistic regression analysis is compared with discriminant analysis, and is found to have important advantages as an epidemiological tool.
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subjectAdult ; Antioxidant vitamins ; Antioxidants - administration & dosage ; Biological and medical sciences ; Blood pressure ; Cardiology. Vascular system ; Cholesterol ; Confounding Factors (Epidemiology) ; Coronary Disease - epidemiology ; Coronary Disease - prevention & control ; Coronary heart disease ; Coronary heart disease risk factors ; Female ; Food frequency questionnaire ; Heart ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Scotland - epidemiology ; Smoking ; Surveys and Questionnaires ; Vitamins - administration & dosage
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abstractAntioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption and prevalent coronary heart disease (CHD), analysing diagnosed and undiagnosed cases separately. For men, there is a protective effect of all three antioxidants, before and after adjustment for a comprehensive set of confounding variables. For women the picture is less clear, only vitamin C is negatively associated with CHD, but the effect is removed by adjustment. The logistic regression model is also used to determine classification rules for deciding whether or not an individual has CHD. The classification error rates using the antioxidants are found to be very similar to those found using smoking, blood pressure and serum total cholesterol as classification variables. Significant interactions are found for the antioxidants with smoking, cholesterol and age. It is concluded that antioxidant vitamin intake protects against CHD for men. Logistic regression analysis is compared with discriminant analysis, and is found to have important advantages as an epidemiological tool.
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doi10.1016/0895-4356(94)00178-S