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Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS

The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly differe... Full description

Journal Title: Neuron 1995-12, Vol.15 (6), p.1375-1381
Main Author: Bartsch, U
Other Authors: Bandtlow, C E , Schnell, L , Bartsch, S , Spillmann, A A , Rubin, B P , Hillenbrand, R , Montag, D , Schwab, M E , Schachner, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Limited
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/8845160
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recordid: cdi_proquest_miscellaneous_77769007
title: Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
format: Article
creator:
  • Bartsch, U
  • Bandtlow, C E
  • Schnell, L
  • Bartsch, S
  • Spillmann, A A
  • Rubin, B P
  • Hillenbrand, R
  • Montag, D
  • Schwab, M E
  • Schachner, M
subjects:
  • 3T3 Cells
  • Animals
  • Antibodies
  • Axons - physiology
  • Cell culture
  • Cell migration
  • Cell spreading
  • Central nervous system
  • Central Nervous System - physiology
  • Cerebellum - cytology
  • Experiments
  • Fibroblasts
  • Ganglia, Spinal - cytology
  • Genotypes
  • Glycoproteins
  • Growth Inhibitors - antagonists & inhibitors
  • Mice
  • Mice, Mutant Strains
  • Myelin
  • Myelin Proteins - pharmacology
  • Myelin-associated glycoprotein
  • Myelin-Associated Glycoprotein - deficiency
  • Myelin-Associated Glycoprotein - pharmacology
  • Myelin-Associated Glycoprotein - physiology
  • Nerve Regeneration
  • Neural Inhibition - physiology
  • Neurites - physiology
  • Neurons
  • Neurons - drug effects
  • Neurons - physiology
  • Neuroscience(all)
  • Neurosciences
  • Optic nerve
  • Optic Nerve - cytology
  • PC12 Cells
  • Proteins
  • Pyramidal tracts
  • Pyramidal Tracts - cytology
  • Rats
  • Regeneration
  • Tumor Cells, Cultured
ispartof: Neuron, 1995-12, Vol.15 (6), p.1375-1381
description: The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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titleLack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
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creatorBartsch, U ; Bandtlow, C E ; Schnell, L ; Bartsch, S ; Spillmann, A A ; Rubin, B P ; Hillenbrand, R ; Montag, D ; Schwab, M E ; Schachner, M
creatorcontribBartsch, U ; Bandtlow, C E ; Schnell, L ; Bartsch, S ; Spillmann, A A ; Rubin, B P ; Hillenbrand, R ; Montag, D ; Schwab, M E ; Schachner, M
descriptionThe MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.
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1EISSN: 1097-4199
2DOI: 10.1016/0896-6273(95)90015-2
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languageeng
publisherUnited States: Elsevier Limited
subject3T3 Cells ; Animals ; Antibodies ; Axons - physiology ; Cell culture ; Cell migration ; Cell spreading ; Central nervous system ; Central Nervous System - physiology ; Cerebellum - cytology ; Experiments ; Fibroblasts ; Ganglia, Spinal - cytology ; Genotypes ; Glycoproteins ; Growth Inhibitors - antagonists & inhibitors ; Mice ; Mice, Mutant Strains ; Myelin ; Myelin Proteins - pharmacology ; Myelin-associated glycoprotein ; Myelin-Associated Glycoprotein - deficiency ; Myelin-Associated Glycoprotein - pharmacology ; Myelin-Associated Glycoprotein - physiology ; Nerve Regeneration ; Neural Inhibition - physiology ; Neurites - physiology ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Neuroscience(all) ; Neurosciences ; Optic nerve ; Optic Nerve - cytology ; PC12 Cells ; Proteins ; Pyramidal tracts ; Pyramidal Tracts - cytology ; Rats ; Regeneration ; Tumor Cells, Cultured
ispartofNeuron, 1995-12, Vol.15 (6), p.1375-1381
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descriptionThe MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.
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03T3 Cells
1Animals
2Antibodies
3Axons - physiology
4Cell culture
5Cell migration
6Cell spreading
7Central nervous system
8Central Nervous System - physiology
9Cerebellum - cytology
10Experiments
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14Glycoproteins
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18Myelin
19Myelin Proteins - pharmacology
20Myelin-associated glycoprotein
21Myelin-Associated Glycoprotein - deficiency
22Myelin-Associated Glycoprotein - pharmacology
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25Neural Inhibition - physiology
26Neurites - physiology
27Neurons
28Neurons - drug effects
29Neurons - physiology
30Neuroscience(all)
31Neurosciences
32Optic nerve
33Optic Nerve - cytology
34PC12 Cells
35Proteins
36Pyramidal tracts
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39Regeneration
40Tumor Cells, Cultured
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titleLack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
authorBartsch, U ; Bandtlow, C E ; Schnell, L ; Bartsch, S ; Spillmann, A A ; Rubin, B P ; Hillenbrand, R ; Montag, D ; Schwab, M E ; Schachner, M
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03T3 Cells
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7Central nervous system
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9Cerebellum - cytology
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11Fibroblasts
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16Mice
17Mice, Mutant Strains
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22Myelin-Associated Glycoprotein - pharmacology
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32Optic nerve
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39Regeneration
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1Bandtlow, C E
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8Schwab, M E
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atitleLack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
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pages1375-1381
issn0896-6273
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abstractThe MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.
copUnited States
pubElsevier Limited
pmid8845160
doi10.1016/0896-6273(95)90015-2
oafree_for_read