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Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques

Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunizatio... Full description

Journal Title: Nature medicine 1996-07, Vol.2 (7), p.767-775
Main Author: Lehner, Thomas
Other Authors: Wang, Yufei , Cranage, Martin , Bergmeier, Lesley A , Mitchell, Elaine , Tao, Louisa , Hall, Graham , Dennis, Mike , Cook, Nicola , Brookes, Roger , Klavinskis, Linda , Jones, Ian , Doyle, Carl , Ward, Robert
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
STD
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/8673922
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title: Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
format: Article
creator:
  • Lehner, Thomas
  • Wang, Yufei
  • Cranage, Martin
  • Bergmeier, Lesley A
  • Mitchell, Elaine
  • Tao, Louisa
  • Hall, Graham
  • Dennis, Mike
  • Cook, Nicola
  • Brookes, Roger
  • Klavinskis, Linda
  • Jones, Ian
  • Doyle, Carl
  • Ward, Robert
subjects:
  • AIDS/HIV
  • Animals
  • Antibodies
  • Antibodies, Viral - biosynthesis
  • Antibody-Producing Cells - immunology
  • B-Lymphocytes - immunology
  • CD8 antigen
  • Chemokines
  • Chemokines - immunology
  • Drainage
  • Fluorescent Dyes
  • Glycoprotein gp120
  • HIV
  • Human immunodeficiency virus
  • Ileum - immunology
  • Immunization
  • Infections
  • Intestinal Mucosa - immunology
  • Lymph nodes
  • Lymph Nodes - immunology
  • Lymph Nodes - virology
  • Lymphatic system
  • Macaca mulatta
  • Male
  • Monkeys & apes
  • Mucosal immunity
  • RANTES
  • Rectum
  • SAIDS Vaccines - immunology
  • Sexually transmitted diseases
  • simian immunodeficiency virus
  • Simian Immunodeficiency Virus - immunology
  • STD
  • Suppressor factor
  • Suppressor Factors, Immunologic - immunology
  • T-Lymphocytes - immunology
  • Vaccines
  • Vaccines, Synthetic - immunology
  • Viremia
  • Viruses
ispartof: Nature medicine, 1996-07, Vol.2 (7), p.767-775
description: Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load ( > 90%) or transient viremia, indicating that all seven TILN-immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of IgA antibody-secreting cells to p27 (P < 0.02), CD8-suppressor factor (P < 0.01), and the chemokines RANTES and MIP-1 beta (P < 0.01).
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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titleProtective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
creatorLehner, Thomas ; Wang, Yufei ; Cranage, Martin ; Bergmeier, Lesley A ; Mitchell, Elaine ; Tao, Louisa ; Hall, Graham ; Dennis, Mike ; Cook, Nicola ; Brookes, Roger ; Klavinskis, Linda ; Jones, Ian ; Doyle, Carl ; Ward, Robert
creatorcontribLehner, Thomas ; Wang, Yufei ; Cranage, Martin ; Bergmeier, Lesley A ; Mitchell, Elaine ; Tao, Louisa ; Hall, Graham ; Dennis, Mike ; Cook, Nicola ; Brookes, Roger ; Klavinskis, Linda ; Jones, Ian ; Doyle, Carl ; Ward, Robert
descriptionPrevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load ( > 90%) or transient viremia, indicating that all seven TILN-immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of IgA antibody-secreting cells to p27 (P < 0.02), CD8-suppressor factor (P < 0.01), and the chemokines RANTES and MIP-1 beta (P < 0.01).
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languageeng
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subjectAIDS/HIV ; Animals ; Antibodies ; Antibodies, Viral - biosynthesis ; Antibody-Producing Cells - immunology ; B-Lymphocytes - immunology ; CD8 antigen ; Chemokines ; Chemokines - immunology ; Drainage ; Fluorescent Dyes ; Glycoprotein gp120 ; HIV ; Human immunodeficiency virus ; Ileum - immunology ; Immunization ; Infections ; Intestinal Mucosa - immunology ; Lymph nodes ; Lymph Nodes - immunology ; Lymph Nodes - virology ; Lymphatic system ; Macaca mulatta ; Male ; Monkeys & apes ; Mucosal immunity ; RANTES ; Rectum ; SAIDS Vaccines - immunology ; Sexually transmitted diseases ; simian immunodeficiency virus ; Simian Immunodeficiency Virus - immunology ; STD ; Suppressor factor ; Suppressor Factors, Immunologic - immunology ; T-Lymphocytes - immunology ; Vaccines ; Vaccines, Synthetic - immunology ; Viremia ; Viruses
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descriptionPrevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load ( > 90%) or transient viremia, indicating that all seven TILN-immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of IgA antibody-secreting cells to p27 (P < 0.02), CD8-suppressor factor (P < 0.01), and the chemokines RANTES and MIP-1 beta (P < 0.01).
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4Antibody-Producing Cells - immunology
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6CD8 antigen
7Chemokines
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13Human immunodeficiency virus
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24Monkeys & apes
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28SAIDS Vaccines - immunology
29Sexually transmitted diseases
30simian immunodeficiency virus
31Simian Immunodeficiency Virus - immunology
32STD
33Suppressor factor
34Suppressor Factors, Immunologic - immunology
35T-Lymphocytes - immunology
36Vaccines
37Vaccines, Synthetic - immunology
38Viremia
39Viruses
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titleProtective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
authorLehner, Thomas ; Wang, Yufei ; Cranage, Martin ; Bergmeier, Lesley A ; Mitchell, Elaine ; Tao, Louisa ; Hall, Graham ; Dennis, Mike ; Cook, Nicola ; Brookes, Roger ; Klavinskis, Linda ; Jones, Ian ; Doyle, Carl ; Ward, Robert
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2Antibodies
3Antibodies, Viral - biosynthesis
4Antibody-Producing Cells - immunology
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7Chemokines
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30simian immunodeficiency virus
31Simian Immunodeficiency Virus - immunology
32STD
33Suppressor factor
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35T-Lymphocytes - immunology
36Vaccines
37Vaccines, Synthetic - immunology
38Viremia
39Viruses
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atitleProtective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
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issn1078-8956
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abstractPrevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load ( > 90%) or transient viremia, indicating that all seven TILN-immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of IgA antibody-secreting cells to p27 (P < 0.02), CD8-suppressor factor (P < 0.01), and the chemokines RANTES and MIP-1 beta (P < 0.01).
copUnited States
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pmid8673922
doi10.1038/nm0796-767