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Verocytotoxin-producing Escherichia coli infection in hemolytic uremic syndrome in part of western Europe

From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producing... Full description

Journal Title: European journal of pediatrics 1996, Vol.155 (7), p.592-595
Main Author: vandeKar, NCAJ
Other Authors: Roelofs, HGR , Muytjens, HL , Tolboom, JJM , Roth, B , Proesmans, W , Wolff, ED , Karmali, MA , Chart, H , Monnens, LAH
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Heidelberg: Springer
ID: ISSN: 0340-6199
Zum Text:
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recordid: cdi_proquest_miscellaneous_78370829
title: Verocytotoxin-producing Escherichia coli infection in hemolytic uremic syndrome in part of western Europe
format: Article
creator:
  • vandeKar, NCAJ
  • Roelofs, HGR
  • Muytjens, HL
  • Tolboom, JJM
  • Roth, B
  • Proesmans, W
  • Wolff, ED
  • Karmali, MA
  • Chart, H
  • Monnens, LAH
subjects:
  • Bacterial diseases
  • Bacterial diseases of the digestive system and abdomen
  • Bacterial Toxins - classification
  • Belgium - epidemiology
  • Biological and medical sciences
  • Case-Control Studies
  • Child
  • Child, Preschool
  • CHILDREN
  • epidemiology
  • Escherichia coli Infections - complications
  • Escherichia coli Infections - microbiology
  • Female
  • Gastroenteritis - complications
  • Gastroenteritis - microbiology
  • Germany - epidemiology
  • haemolytic uraemic syndrome
  • Hemolytic-Uremic Syndrome - epidemiology
  • Human bacterial diseases
  • Humans
  • Infant
  • Infectious diseases
  • Male
  • Medical sciences
  • Netherlands - epidemiology
  • O-157
  • O157-H7
  • Prospective Studies
  • Serotyping
  • verocytotoxin-producing Escherichia coli
ispartof: European journal of pediatrics, 1996, Vol.155 (7), p.592-595
description: From September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producing Escherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts. Conclusion In this part of Western Europe, VT2-producing Escherichia coli, mainly those belonging to serogroup O157, are the major cause of HUS in childhood.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0340-6199
fulltext: fulltext
issn:
  • 0340-6199
  • 1432-1076
url: Link


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titleVerocytotoxin-producing Escherichia coli infection in hemolytic uremic syndrome in part of western Europe
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creatorvandeKar, NCAJ ; Roelofs, HGR ; Muytjens, HL ; Tolboom, JJM ; Roth, B ; Proesmans, W ; Wolff, ED ; Karmali, MA ; Chart, H ; Monnens, LAH
creatorcontribvandeKar, NCAJ ; Roelofs, HGR ; Muytjens, HL ; Tolboom, JJM ; Roth, B ; Proesmans, W ; Wolff, ED ; Karmali, MA ; Chart, H ; Monnens, LAH
descriptionFrom September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producing Escherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts. Conclusion In this part of Western Europe, VT2-producing Escherichia coli, mainly those belonging to serogroup O157, are the major cause of HUS in childhood.
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subjectBacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacterial Toxins - classification ; Belgium - epidemiology ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; CHILDREN ; epidemiology ; Escherichia coli Infections - complications ; Escherichia coli Infections - microbiology ; Female ; Gastroenteritis - complications ; Gastroenteritis - microbiology ; Germany - epidemiology ; haemolytic uraemic syndrome ; Hemolytic-Uremic Syndrome - epidemiology ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Netherlands - epidemiology ; O-157 ; O157-H7 ; Prospective Studies ; Serotyping ; verocytotoxin-producing Escherichia coli
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0Verocytotoxin-producing Escherichia coli infection in hemolytic uremic syndrome in part of western Europe
1European journal of pediatrics
addtitleEur J Pediatr
descriptionFrom September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producing Escherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts. Conclusion In this part of Western Europe, VT2-producing Escherichia coli, mainly those belonging to serogroup O157, are the major cause of HUS in childhood.
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4Biological and medical sciences
5Case-Control Studies
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12Female
13Gastroenteritis - complications
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abstractFrom September 1989 until September 1993, stool specimens and sera from 113 children with diarrhoea-associated haemolytic uraemic syndrome (HUS) from the Netherlands, two university hospitals in Belgium and one university hospital in Germany were examined for the presence of verocytotoxin-producing Escherichia coli (VTEC) infection. Evidence for VTEC infection was observed in 88 (78%) patients with HUS compared to 2 (3%) of the 65 children with acute gastro-enteritis Serotype O157 was the causative agent in 76 (86%) of these 88 patients with VTEC-associated HUS and verocytotoxin-2 (VT-2) was the most frequent toxin produced. Serological testing for antibodies to O157 O-antigen yielded the highest number of positive results compared to the other test methods. Antibodies to O157 were found in sera of 71 (65%) of 110 patients with HUS and one control serum. Stool and sera examination for VTEC in 95 family contacts of 28 patients with HUS demonstrated an evidence for VTEC infection 33 (35%). In contrast, in patients with HUS serological antibodies to O157 O-antigen were found in only 3 (4%) of 85 family contacts. Conclusion In this part of Western Europe, VT2-producing Escherichia coli, mainly those belonging to serogroup O157, are the major cause of HUS in childhood.
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