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The apolipoprotein E polymorphism in Greenland Inuit in its global perspective

Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relativ... Full description

Journal Title: Human genetics 1996, Vol.98 (5), p.546-550
Main Author: GERDES, L. U
Other Authors: GERDES, C , HANSEN, P. S , KLAUSEN, I. C , FAERGEMAN, O , DYERBERG, J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Heidelberg: Springer
ID: ISSN: 0340-6717
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recordid: cdi_proquest_miscellaneous_78464987
title: The apolipoprotein E polymorphism in Greenland Inuit in its global perspective
format: Article
creator:
  • GERDES, L. U
  • GERDES, C
  • HANSEN, P. S
  • KLAUSEN, I. C
  • FAERGEMAN, O
  • DYERBERG, J
subjects:
  • Alleles
  • Apolipoproteins B - blood
  • Apolipoproteins E - genetics
  • Biological and medical sciences
  • Cholesterol, HDL - blood
  • Cholesterol, LDL - blood
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Genetics of eukaryotes. Biological and molecular evolution
  • Genotype
  • Greenland
  • Human
  • Humans
  • Inuits - genetics
  • Male
  • Polymorphism, Genetic
  • Population genetics, reproduction patterns
  • Sex Characteristics
  • Triglycerides - blood
ispartof: Human genetics, 1996, Vol.98 (5), p.546-550
description: Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
language: eng
source:
identifier: ISSN: 0340-6717
fulltext: no_fulltext
issn:
  • 0340-6717
  • 1432-1203
url: Link


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titleThe apolipoprotein E polymorphism in Greenland Inuit in its global perspective
creatorGERDES, L. U ; GERDES, C ; HANSEN, P. S ; KLAUSEN, I. C ; FAERGEMAN, O ; DYERBERG, J
creatorcontribGERDES, L. U ; GERDES, C ; HANSEN, P. S ; KLAUSEN, I. C ; FAERGEMAN, O ; DYERBERG, J
descriptionApolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
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subjectAlleles ; Apolipoproteins B - blood ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Greenland ; Human ; Humans ; Inuits - genetics ; Male ; Polymorphism, Genetic ; Population genetics, reproduction patterns ; Sex Characteristics ; Triglycerides - blood
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descriptionApolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
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titleThe apolipoprotein E polymorphism in Greenland Inuit in its global perspective
authorGERDES, L. U ; GERDES, C ; HANSEN, P. S ; KLAUSEN, I. C ; FAERGEMAN, O ; DYERBERG, J
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abstractApolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
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