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Aminoglycoside Levels in the Rabbit Vitreous Cavity After Intravenous Administration

To determine the penetration of gentamicin and amikacin into the rabbit vitreous cavity after their intravenous administration. Gentamicin (1.6 mg/kg every 8 hours) and amikacin (6 mg/kg every 12 hours) were administered intravenously to 25 rabbits that had previously had the lens and vitreous remov... Full description

Journal Title: American journal of ophthalmology 1996, Vol.122 (5), p.684-689
Main Author: EL-MASSRY, AHMED
Other Authors: MEREDITH, TRAVIS A , AGUILAR, H. EDITH , SHAARAWY, ASHRAF , KINCAID, MARILYN , DICK, JAMES , MAHMOUD, MAHMOUD I.E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9394
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title: Aminoglycoside Levels in the Rabbit Vitreous Cavity After Intravenous Administration
format: Article
creator:
  • EL-MASSRY, AHMED
  • MEREDITH, TRAVIS A
  • AGUILAR, H. EDITH
  • SHAARAWY, ASHRAF
  • KINCAID, MARILYN
  • DICK, JAMES
  • MAHMOUD, MAHMOUD I.E
subjects:
  • Abridged Index Medicus
  • Amikacin
  • Amikacin - administration & dosage
  • Amikacin - pharmacokinetics
  • Aminoglycosides
  • Animals
  • Anti-Bacterial Agents - administration & dosage
  • Anti-Bacterial Agents - pharmacokinetics
  • Antibacterial agents
  • Antibiotics. Antiinfectious agents. Antiparasitic agents
  • Aphakia - metabolism
  • Bioavailability
  • Biological and medical sciences
  • Biological Availability
  • Eye Infections, Bacterial - etiology
  • Eye Infections, Bacterial - metabolism
  • Gentamicin
  • Gentamicins - administration & dosage
  • Gentamicins - pharmacokinetics
  • Injections, Intravenous
  • Lens, Crystalline - surgery
  • Measurement
  • Medical sciences
  • Ophthalmology
  • Pharmacology. Drug treatments
  • Physiological aspects
  • Rabbits
  • Staphylococcal Infections - etiology
  • Staphylococcal Infections - metabolism
  • Staphylococcus epidermidis
  • Uveitis - metabolism
  • Uveitis - microbiology
  • Vitrectomy
  • Vitreous Body - metabolism
ispartof: American journal of ophthalmology, 1996, Vol.122 (5), p.684-689
description: To determine the penetration of gentamicin and amikacin into the rabbit vitreous cavity after their intravenous administration. Gentamicin (1.6 mg/kg every 8 hours) and amikacin (6 mg/kg every 12 hours) were administered intravenously to 25 rabbits that had previously had the lens and vitreous removed from 43 eyes. For each drug, ocular inflammation was induced in one group of eyes by injection of heat-killed Staphylococcus epidermidis, while the other group was maintained as a control. Samples from the vitreous cavity were taken at regular intervals for 72 hours after beginning the intravenous medications and were analyzed for drug concentrations. The maximum intravitreal concentration ± SD achieved for gentamicin was 1.8 ± 0.5 μg/ml. The maximum intravitreal concentration for amikacin was 8.5 ±3.2 μg/ml. Inflamed eyes demonstrated higher concentrations than did those without inflammation. In a rabbit model with conditions optimized to enhance penetration of antimicrobials into the vitreous cavity after intravenous administration, neither gentamicin nor amikacin penetrated sufficiently to reach potentially therapeutic concentrations consistently for either Pseudomonas or S epidermidis organisms.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9394
fulltext: fulltext
issn:
  • 0002-9394
  • 1879-1891
url: Link


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titleAminoglycoside Levels in the Rabbit Vitreous Cavity After Intravenous Administration
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creatorEL-MASSRY, AHMED ; MEREDITH, TRAVIS A ; AGUILAR, H. EDITH ; SHAARAWY, ASHRAF ; KINCAID, MARILYN ; DICK, JAMES ; MAHMOUD, MAHMOUD I.E
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descriptionTo determine the penetration of gentamicin and amikacin into the rabbit vitreous cavity after their intravenous administration. Gentamicin (1.6 mg/kg every 8 hours) and amikacin (6 mg/kg every 12 hours) were administered intravenously to 25 rabbits that had previously had the lens and vitreous removed from 43 eyes. For each drug, ocular inflammation was induced in one group of eyes by injection of heat-killed Staphylococcus epidermidis, while the other group was maintained as a control. Samples from the vitreous cavity were taken at regular intervals for 72 hours after beginning the intravenous medications and were analyzed for drug concentrations. The maximum intravitreal concentration ± SD achieved for gentamicin was 1.8 ± 0.5 μg/ml. The maximum intravitreal concentration for amikacin was 8.5 ±3.2 μg/ml. Inflamed eyes demonstrated higher concentrations than did those without inflammation. In a rabbit model with conditions optimized to enhance penetration of antimicrobials into the vitreous cavity after intravenous administration, neither gentamicin nor amikacin penetrated sufficiently to reach potentially therapeutic concentrations consistently for either Pseudomonas or S epidermidis organisms.
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Amikacin ; Amikacin - administration & dosage ; Amikacin - pharmacokinetics ; Aminoglycosides ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Aphakia - metabolism ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Eye Infections, Bacterial - etiology ; Eye Infections, Bacterial - metabolism ; Gentamicin ; Gentamicins - administration & dosage ; Gentamicins - pharmacokinetics ; Injections, Intravenous ; Lens, Crystalline - surgery ; Measurement ; Medical sciences ; Ophthalmology ; Pharmacology. Drug treatments ; Physiological aspects ; Rabbits ; Staphylococcal Infections - etiology ; Staphylococcal Infections - metabolism ; Staphylococcus epidermidis ; Uveitis - metabolism ; Uveitis - microbiology ; Vitrectomy ; Vitreous Body - metabolism
ispartofAmerican journal of ophthalmology, 1996, Vol.122 (5), p.684-689
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addtitleAm J Ophthalmol
descriptionTo determine the penetration of gentamicin and amikacin into the rabbit vitreous cavity after their intravenous administration. Gentamicin (1.6 mg/kg every 8 hours) and amikacin (6 mg/kg every 12 hours) were administered intravenously to 25 rabbits that had previously had the lens and vitreous removed from 43 eyes. For each drug, ocular inflammation was induced in one group of eyes by injection of heat-killed Staphylococcus epidermidis, while the other group was maintained as a control. Samples from the vitreous cavity were taken at regular intervals for 72 hours after beginning the intravenous medications and were analyzed for drug concentrations. The maximum intravitreal concentration ± SD achieved for gentamicin was 1.8 ± 0.5 μg/ml. The maximum intravitreal concentration for amikacin was 8.5 ±3.2 μg/ml. Inflamed eyes demonstrated higher concentrations than did those without inflammation. In a rabbit model with conditions optimized to enhance penetration of antimicrobials into the vitreous cavity after intravenous administration, neither gentamicin nor amikacin penetrated sufficiently to reach potentially therapeutic concentrations consistently for either Pseudomonas or S epidermidis organisms.
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1Amikacin
2Amikacin - administration & dosage
3Amikacin - pharmacokinetics
4Aminoglycosides
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6Anti-Bacterial Agents - administration & dosage
7Anti-Bacterial Agents - pharmacokinetics
8Antibacterial agents
9Antibiotics. Antiinfectious agents. Antiparasitic agents
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12Biological and medical sciences
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14Eye Infections, Bacterial - etiology
15Eye Infections, Bacterial - metabolism
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20Lens, Crystalline - surgery
21Measurement
22Medical sciences
23Ophthalmology
24Pharmacology. Drug treatments
25Physiological aspects
26Rabbits
27Staphylococcal Infections - etiology
28Staphylococcal Infections - metabolism
29Staphylococcus epidermidis
30Uveitis - metabolism
31Uveitis - microbiology
32Vitrectomy
33Vitreous Body - metabolism
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titleAminoglycoside Levels in the Rabbit Vitreous Cavity After Intravenous Administration
authorEL-MASSRY, AHMED ; MEREDITH, TRAVIS A ; AGUILAR, H. EDITH ; SHAARAWY, ASHRAF ; KINCAID, MARILYN ; DICK, JAMES ; MAHMOUD, MAHMOUD I.E
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abstractTo determine the penetration of gentamicin and amikacin into the rabbit vitreous cavity after their intravenous administration. Gentamicin (1.6 mg/kg every 8 hours) and amikacin (6 mg/kg every 12 hours) were administered intravenously to 25 rabbits that had previously had the lens and vitreous removed from 43 eyes. For each drug, ocular inflammation was induced in one group of eyes by injection of heat-killed Staphylococcus epidermidis, while the other group was maintained as a control. Samples from the vitreous cavity were taken at regular intervals for 72 hours after beginning the intravenous medications and were analyzed for drug concentrations. The maximum intravitreal concentration ± SD achieved for gentamicin was 1.8 ± 0.5 μg/ml. The maximum intravitreal concentration for amikacin was 8.5 ±3.2 μg/ml. Inflamed eyes demonstrated higher concentrations than did those without inflammation. In a rabbit model with conditions optimized to enhance penetration of antimicrobials into the vitreous cavity after intravenous administration, neither gentamicin nor amikacin penetrated sufficiently to reach potentially therapeutic concentrations consistently for either Pseudomonas or S epidermidis organisms.
copNew York, NY
pubElsevier Inc
pmid8909208
doi10.1016/S0002-9394(14)70487-8