Structure and properties of TentaGel resin beads: Implications for combinatorial library chemistry
| Journal Title: | Molecular diversity 1996-08, Vol.1 (4), p.223-232 |
| Main Author: | Quarrell, R |
| Other Authors: | Claridge, T D , Weaver, G W , Lowe, G |
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 Electronic Article
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| Language: |
English |
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| Publisher: | Netherlands |
| ID: | ISSN: 1381-1991 |
| Link: | https://www.ncbi.nlm.nih.gov/pubmed/9237213 |
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| recordid: | cdi_proquest_miscellaneous_78731012 |
| title: | Structure and properties of TentaGel resin beads: Implications for combinatorial library chemistry |
| format: | Article |
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| ispartof: | Molecular diversity, 1996-08, Vol.1 (4), p.223-232 |
| description: | In view of the widespread use of TentaGel resin beads for the synthesis of combinatorial libraries, the properties of TentaGel resin have been examined using a combination of confocal laser microscopy and NMR spectroscopy. Evidence is presented that trypsin, a 23.5-kDa enzyme, can penetrate to the core of 90-microns TentaGel beads, and that the matrix of such beads permits molecular motion at a similar rate to that in solution. The beads act as a separate gel phase rather than as a porous solid. These conclusions have important implications for the bioassay of on-bead combinatorial chemical libraries. |
| language: | eng |
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| identifier: | ISSN: 1381-1991 |
| fulltext: | no_fulltext |
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| url: | Link |
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