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The Apolipoprotein E Phenotype Has a Strong Influence on Tracking of Serum Cholesterol and Lipoprotein Levels in Children: A Follow-Up Study from Birth to the Age of 11 Years

The extent to which an individual maintains his position relative to the rest of the population is called tracking. The objective of this study was to examine the effect of the apolipoprotein E (apoE) phenotype on the tracking of serum cholesterol and lipoproteins from birth to the age of 11 y. In a... Full description

Journal Title: Pediatric research 1998, Vol.43 (3), p.381-385
Main Author: KALLIO, M. J. T
Other Authors: SALMENPERÄ, L , SIIMES, M. A , PERHEENTUPA, J , GYLLING, H , MIETTINEN, T. A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0031-3998
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recordid: cdi_proquest_miscellaneous_79730094
title: The Apolipoprotein E Phenotype Has a Strong Influence on Tracking of Serum Cholesterol and Lipoprotein Levels in Children: A Follow-Up Study from Birth to the Age of 11 Years
format: Article
creator:
  • KALLIO, M. J. T
  • SALMENPERÄ, L
  • SIIMES, M. A
  • PERHEENTUPA, J
  • GYLLING, H
  • MIETTINEN, T. A
subjects:
  • Apolipoproteins E - genetics
  • Biological and medical sciences
  • Child
  • Child, Preschool
  • Cholesterol - blood
  • Cholesterol, LDL - blood
  • Disorders of blood lipids. Hyperlipoproteinemia
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Lipoproteins - blood
  • Longitudinal Studies
  • Medical sciences
  • Metabolic diseases
  • Phenotype
  • Pregnancy
ispartof: Pediatric research, 1998, Vol.43 (3), p.381-385
description: The extent to which an individual maintains his position relative to the rest of the population is called tracking. The objective of this study was to examine the effect of the apolipoprotein E (apoE) phenotype on the tracking of serum cholesterol and lipoproteins from birth to the age of 11 y. In a longitudinal follow-up study of healthy children, concentrations of total serum cholesterol and triglyceride were determined at birth (n = 193), and at the ages of 2 (n = 192), 4 (n = 192), 6 (n = 190), 9 (n = 188), and 12 mo (n = 196), and 5 (n = 162) and 11 y (n = 153). Concentrations of total HDL, HDL2, and HDL3, VLDL, and LDL cholesterol were determined at 2, 6, 9, and 12 mo (n = 36), and 5 (n = 162) and 11 y (n = 153). The apoE phenotype was determined in 151 children. The children had the following apoE phenotypes: 4 had type 4/4 and 40 type 3/4 (group apoE4), 94 had type 3/3 (group apoE3), and 11 had type 2/3 and 2 type 2/4 (group apoE2). The correlation coefficients for total cholesterol levels during childhood compared with the level at 11 y of age were: 0.03 at birth, 0.26 (p < 0.001) at 2 mo, 0.24 (p < 0.001) at 4 mo, 0.24 (p < 0.001) at 6 mo, 0.28 (p < 0.001) at 9 mo, 0.41 (p < 0.001) at 12 mo, and 0.60 (p < 0.001) at 5 y. When the children were divided into three groups according to their apoE phenotypes, these three groups had the following correlation coefficients at 4 mo, 12 mo, or 5 y of age compared with the level at the age of 11 y; group apoE2: r = 0.65 (p < 0.01), r = 0.59 (p < 0.01), and r = 0.72 (p < 0.01); group apoE3: r = 0.27 (p < 0.01), 0.43 (p < 0.001), and r = 0.64 (p < 0.001); and group apoE4: r = 0.14 (p = NS), r = 0.33 (p < 0.05), and 0.42 (p < 0.01). The apoE phenotype also strongly influenced the tracking of the LDL cholesterol levels; the correlation coefficients between 5 and 11 y of age were for group apoE2 r = 0.84 (p < 0.001), for group apoE3 r = 0.70 (p < 0.001), and for group apoE4 r = 0.37 (p < 0.05). Our results indicate that the apoE phenotype strongly influences the tracking of lipids. The children having apoE 2/3, 2/4, and 3/3 phenotypes maintained their relative cholesterol and lipoprotein levels better than the others throughout the first 11 y of age. Because the apoE phenotype strongly affects the tracking of serum cholesterol, the usefulness of cholesterol screening in predicting future cholesterol values should be analyzed, keeping the apoE phenotype in mind.
language: eng
source:
identifier: ISSN: 0031-3998
fulltext: no_fulltext
issn:
  • 0031-3998
  • 1530-0447
url: Link


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creatorKALLIO, M. J. T ; SALMENPERÄ, L ; SIIMES, M. A ; PERHEENTUPA, J ; GYLLING, H ; MIETTINEN, T. A
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subjectApolipoproteins E - genetics ; Biological and medical sciences ; Child ; Child, Preschool ; Cholesterol - blood ; Cholesterol, LDL - blood ; Disorders of blood lipids. Hyperlipoproteinemia ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Lipoproteins - blood ; Longitudinal Studies ; Medical sciences ; Metabolic diseases ; Phenotype ; Pregnancy
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