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Antenatal dexamethasone treatment decreases plasma catecholamine levels in preterm infants

Antenatal corticosteroid therapy (ACT) has many beneficial effects on preterm infants. The cellular mechanisms of action of ACT include beta-adrenergic receptor-mediated cAMP generation. This study investigated the effects of ACT on sympathoadrenal mechanisms during immediate postnatal adaptation of... Full description

Journal Title: Pediatric research 1998, Vol.43 (6), p.801-807
Main Author: KALLIO, J
Other Authors: KARLSSON, R , TOPPARI, J , HELMINEN, T , SCHEININ, M , KERO, P
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0031-3998
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recordid: cdi_proquest_miscellaneous_79929880
title: Antenatal dexamethasone treatment decreases plasma catecholamine levels in preterm infants
format: Article
creator:
  • KALLIO, J
  • KARLSSON, R
  • TOPPARI, J
  • HELMINEN, T
  • SCHEININ, M
  • KERO, P
subjects:
  • Antihypertensive Agents - therapeutic use
  • Biological and medical sciences
  • Birth Weight
  • Cyclic AMP - blood
  • Delivery, Obstetric
  • Dexamethasone - administration & dosage
  • Dexamethasone - therapeutic use
  • Diseases of mother, fetus and pregnancy
  • Epinephrine - blood
  • Female
  • Gestational Age
  • Gynecology. Andrology. Obstetrics
  • Humans
  • Hypertension - drug therapy
  • Infant, Newborn
  • Infant, Premature - blood
  • Male
  • Medical sciences
  • Methoxyhydroxyphenylglycol - analogs & derivatives
  • Methoxyhydroxyphenylglycol - blood
  • Norepinephrine - blood
  • Pregnancy
  • Pregnancy Complications, Cardiovascular - drug therapy
  • Pregnancy. Fetus. Placenta
  • Prenatal Care
  • Regression Analysis
  • Respiratory Distress Syndrome, Newborn - prevention & control
  • Tocolytic Agents - therapeutic use
ispartof: Pediatric research, 1998, Vol.43 (6), p.801-807
description: Antenatal corticosteroid therapy (ACT) has many beneficial effects on preterm infants. The cellular mechanisms of action of ACT include beta-adrenergic receptor-mediated cAMP generation. This study investigated the effects of ACT on sympathoadrenal mechanisms during immediate postnatal adaptation of preterm infants. Plasma epinephrine, norepinephrine, 3,4-dihydroxyphenylglycol, and cAMP were measured within 12 h after birth in 103 preterm infants (gestational age 24-36 wk), who were divided into two groups (non-ACT and ACT group) according to whether the mother had received dexamethasone treatment. Infants in the ACT group had significantly lower concentrations of plasma catecholamines than infants in the non-ACT group; plasma epinephrine was 38% lower, and plasma norepinephrine was 20-40% lower in the ACT group, depending on gestational age (r = -0.37 in the non-ACT group and r = -0.28 in the ACT group, p < 0.05). Plasma cAMP concentrations were similar in the two groups. Antihypertensive treatment of the mother was associated with low plasma cAMP (p < 0.001), whereas tocolytic treatment was associated with high plasma cAMP (p = 0.001) of the infant. The results indicate that ACT attenuates the birth-related increase in plasma catecholamines. Still, plasma cAMP levels remain high, which suggests enhanced beta-adrenoceptor signaling after ACT.
language: eng
source:
identifier: ISSN: 0031-3998
fulltext: no_fulltext
issn:
  • 0031-3998
  • 1530-0447
url: Link


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titleAntenatal dexamethasone treatment decreases plasma catecholamine levels in preterm infants
creatorKALLIO, J ; KARLSSON, R ; TOPPARI, J ; HELMINEN, T ; SCHEININ, M ; KERO, P
creatorcontribKALLIO, J ; KARLSSON, R ; TOPPARI, J ; HELMINEN, T ; SCHEININ, M ; KERO, P
descriptionAntenatal corticosteroid therapy (ACT) has many beneficial effects on preterm infants. The cellular mechanisms of action of ACT include beta-adrenergic receptor-mediated cAMP generation. This study investigated the effects of ACT on sympathoadrenal mechanisms during immediate postnatal adaptation of preterm infants. Plasma epinephrine, norepinephrine, 3,4-dihydroxyphenylglycol, and cAMP were measured within 12 h after birth in 103 preterm infants (gestational age 24-36 wk), who were divided into two groups (non-ACT and ACT group) according to whether the mother had received dexamethasone treatment. Infants in the ACT group had significantly lower concentrations of plasma catecholamines than infants in the non-ACT group; plasma epinephrine was 38% lower, and plasma norepinephrine was 20-40% lower in the ACT group, depending on gestational age (r = -0.37 in the non-ACT group and r = -0.28 in the ACT group, p < 0.05). Plasma cAMP concentrations were similar in the two groups. Antihypertensive treatment of the mother was associated with low plasma cAMP (p < 0.001), whereas tocolytic treatment was associated with high plasma cAMP (p = 0.001) of the infant. The results indicate that ACT attenuates the birth-related increase in plasma catecholamines. Still, plasma cAMP levels remain high, which suggests enhanced beta-adrenoceptor signaling after ACT.
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0ISSN: 0031-3998
1EISSN: 1530-0447
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3PMID: 9621991
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languageeng
publisherHagerstown, MD: Lippincott Williams & Wilkins
subjectAntihypertensive Agents - therapeutic use ; Biological and medical sciences ; Birth Weight ; Cyclic AMP - blood ; Delivery, Obstetric ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Diseases of mother, fetus and pregnancy ; Epinephrine - blood ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension - drug therapy ; Infant, Newborn ; Infant, Premature - blood ; Male ; Medical sciences ; Methoxyhydroxyphenylglycol - analogs & derivatives ; Methoxyhydroxyphenylglycol - blood ; Norepinephrine - blood ; Pregnancy ; Pregnancy Complications, Cardiovascular - drug therapy ; Pregnancy. Fetus. Placenta ; Prenatal Care ; Regression Analysis ; Respiratory Distress Syndrome, Newborn - prevention & control ; Tocolytic Agents - therapeutic use
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title
0Antenatal dexamethasone treatment decreases plasma catecholamine levels in preterm infants
1Pediatric research
addtitlePediatr Res
descriptionAntenatal corticosteroid therapy (ACT) has many beneficial effects on preterm infants. The cellular mechanisms of action of ACT include beta-adrenergic receptor-mediated cAMP generation. This study investigated the effects of ACT on sympathoadrenal mechanisms during immediate postnatal adaptation of preterm infants. Plasma epinephrine, norepinephrine, 3,4-dihydroxyphenylglycol, and cAMP were measured within 12 h after birth in 103 preterm infants (gestational age 24-36 wk), who were divided into two groups (non-ACT and ACT group) according to whether the mother had received dexamethasone treatment. Infants in the ACT group had significantly lower concentrations of plasma catecholamines than infants in the non-ACT group; plasma epinephrine was 38% lower, and plasma norepinephrine was 20-40% lower in the ACT group, depending on gestational age (r = -0.37 in the non-ACT group and r = -0.28 in the ACT group, p < 0.05). Plasma cAMP concentrations were similar in the two groups. Antihypertensive treatment of the mother was associated with low plasma cAMP (p < 0.001), whereas tocolytic treatment was associated with high plasma cAMP (p = 0.001) of the infant. The results indicate that ACT attenuates the birth-related increase in plasma catecholamines. Still, plasma cAMP levels remain high, which suggests enhanced beta-adrenoceptor signaling after ACT.
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0Antihypertensive Agents - therapeutic use
1Biological and medical sciences
2Birth Weight
3Cyclic AMP - blood
4Delivery, Obstetric
5Dexamethasone - administration & dosage
6Dexamethasone - therapeutic use
7Diseases of mother, fetus and pregnancy
8Epinephrine - blood
9Female
10Gestational Age
11Gynecology. Andrology. Obstetrics
12Humans
13Hypertension - drug therapy
14Infant, Newborn
15Infant, Premature - blood
16Male
17Medical sciences
18Methoxyhydroxyphenylglycol - analogs & derivatives
19Methoxyhydroxyphenylglycol - blood
20Norepinephrine - blood
21Pregnancy
22Pregnancy Complications, Cardiovascular - drug therapy
23Pregnancy. Fetus. Placenta
24Prenatal Care
25Regression Analysis
26Respiratory Distress Syndrome, Newborn - prevention & control
27Tocolytic Agents - therapeutic use
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1KARLSSON, R
2TOPPARI, J
3HELMINEN, T
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titleAntenatal dexamethasone treatment decreases plasma catecholamine levels in preterm infants
authorKALLIO, J ; KARLSSON, R ; TOPPARI, J ; HELMINEN, T ; SCHEININ, M ; KERO, P
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1Biological and medical sciences
2Birth Weight
3Cyclic AMP - blood
4Delivery, Obstetric
5Dexamethasone - administration & dosage
6Dexamethasone - therapeutic use
7Diseases of mother, fetus and pregnancy
8Epinephrine - blood
9Female
10Gestational Age
11Gynecology. Andrology. Obstetrics
12Humans
13Hypertension - drug therapy
14Infant, Newborn
15Infant, Premature - blood
16Male
17Medical sciences
18Methoxyhydroxyphenylglycol - analogs & derivatives
19Methoxyhydroxyphenylglycol - blood
20Norepinephrine - blood
21Pregnancy
22Pregnancy Complications, Cardiovascular - drug therapy
23Pregnancy. Fetus. Placenta
24Prenatal Care
25Regression Analysis
26Respiratory Distress Syndrome, Newborn - prevention & control
27Tocolytic Agents - therapeutic use
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abstractAntenatal corticosteroid therapy (ACT) has many beneficial effects on preterm infants. The cellular mechanisms of action of ACT include beta-adrenergic receptor-mediated cAMP generation. This study investigated the effects of ACT on sympathoadrenal mechanisms during immediate postnatal adaptation of preterm infants. Plasma epinephrine, norepinephrine, 3,4-dihydroxyphenylglycol, and cAMP were measured within 12 h after birth in 103 preterm infants (gestational age 24-36 wk), who were divided into two groups (non-ACT and ACT group) according to whether the mother had received dexamethasone treatment. Infants in the ACT group had significantly lower concentrations of plasma catecholamines than infants in the non-ACT group; plasma epinephrine was 38% lower, and plasma norepinephrine was 20-40% lower in the ACT group, depending on gestational age (r = -0.37 in the non-ACT group and r = -0.28 in the ACT group, p < 0.05). Plasma cAMP concentrations were similar in the two groups. Antihypertensive treatment of the mother was associated with low plasma cAMP (p < 0.001), whereas tocolytic treatment was associated with high plasma cAMP (p = 0.001) of the infant. The results indicate that ACT attenuates the birth-related increase in plasma catecholamines. Still, plasma cAMP levels remain high, which suggests enhanced beta-adrenoceptor signaling after ACT.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid9621991
doi10.1203/00006450-199806000-00014
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