schliessen

Filtern

 

Bibliotheken

Saluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion

The effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees. After a control period of 3 days torasemide 20 mg i.v. caused a dramatic increase in diuresis and electrolyte excretion without affecting the glomerular filtration r... Full description

Journal Title: European journal of clinical pharmacology 1990, Vol.39 (4), p.337-343
Main Author: Knauf, H
Other Authors: Mutschler, E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Germany
ID: ISSN: 0031-6970
Link: https://www.ncbi.nlm.nih.gov/pubmed/2076714
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_80288079
title: Saluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion
format: Article
creator:
  • Knauf, H
  • Mutschler, E
subjects:
  • Adult
  • Aged
  • Calcium - urine
  • Chlorides - urine
  • Diuresis - drug effects
  • Diuretics - administration & dosage
  • Diuretics - pharmacology
  • Dose-Response Relationship, Drug
  • Electrolytes - urine
  • Female
  • Humans
  • Injections, Intravenous
  • Kidney Failure, Chronic - urine
  • Magnesium - urine
  • Male
  • Middle Aged
  • Natriuresis - drug effects
  • Potassium - urine
  • salt
  • Sulfonamides - administration & dosage
  • Sulfonamides - pharmacokinetics
  • Sulfonamides - pharmacology
  • torasemide
  • Torsemide
ispartof: European journal of clinical pharmacology, 1990, Vol.39 (4), p.337-343
description: The effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees. After a control period of 3 days torasemide 20 mg i.v. caused a dramatic increase in diuresis and electrolyte excretion without affecting the glomerular filtration rate. The duration of action of torasemide, tau, averaged 6 h and was independent of the creatinine clearance, CLCR. When related to tau the drug-induced excretion of Cl-, Na+, K+, Ca2+ and Mg2+ showed strong linear dependence on CLCR. Both the kaliuresis and the calciuresis during tau were tightly correlated with the natriuresis over the broad range of CLCR. Similarly, the excretion of Mg2+ was dependent on the kaliuresis. The torasemide-induced kaliuresis amounted to 12% of natriuresis, as after furosemide. The kaliuretic effect of loop diuretics is smaller than that of the thiazides. After tau, e.g. over a 24 h period, kaliuresis was not correlated with natriuresis. The magnitude of the rebound effect was diminished with increasing renal impairment.
language: eng
source:
identifier: ISSN: 0031-6970
fulltext: no_fulltext
issn:
  • 0031-6970
  • 1432-1041
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK1.6007692
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_80288079
sourceformatXML
sourcesystemPC
sourcerecordid80288079
originalsourceidFETCH-LOGICAL-c287t-8e7d2d82337f975831bb1e739c65b5f9057e9e2834dc379287ea690724804c8a0
addsrcrecordideNqFkTFPwzAQRi0EKqWwsCN5YkBKOdtJbI9QUahUiQGYI8e5qEFJXOxEov-eRI1gZDrpu3dvuI-QawZLBiDvH9cAgiUxpCdkzmLBIwYxOyXzMY5SLeGcXITwCcASDWJGZhxkKlk8J-HN1L3HrrIUyxJtR11Jux3S2rk9Lapp1zlvAjZVgbRqqd151w6px9bUtDTVqFjSTduhL3CPbYGtxdGE9aD0rj50SPHbjjLXXpKz0tQBr6a5IB_rp_fVS7R9fd6sHraR5Up2kUJZ8EJxIWSpZaIEy3OGUmibJnlSakgkauRKxIUVUg83aFINkscKYqsMLMjt0bv37qvH0GVNFSzWtWnR9SFTwJUCqf8FWcr48F82gHdH0HoXgscy2_uqMf6QMcjGKrK_Kgb4ZrL2eYPFLzr9Hn4AsGSDkw
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid16123151
display
typearticle
titleSaluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion
creatorKnauf, H ; Mutschler, E
creatorcontribKnauf, H ; Mutschler, E
descriptionThe effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees. After a control period of 3 days torasemide 20 mg i.v. caused a dramatic increase in diuresis and electrolyte excretion without affecting the glomerular filtration rate. The duration of action of torasemide, tau, averaged 6 h and was independent of the creatinine clearance, CLCR. When related to tau the drug-induced excretion of Cl-, Na+, K+, Ca2+ and Mg2+ showed strong linear dependence on CLCR. Both the kaliuresis and the calciuresis during tau were tightly correlated with the natriuresis over the broad range of CLCR. Similarly, the excretion of Mg2+ was dependent on the kaliuresis. The torasemide-induced kaliuresis amounted to 12% of natriuresis, as after furosemide. The kaliuretic effect of loop diuretics is smaller than that of the thiazides. After tau, e.g. over a 24 h period, kaliuresis was not correlated with natriuresis. The magnitude of the rebound effect was diminished with increasing renal impairment.
identifier
0ISSN: 0031-6970
1EISSN: 1432-1041
2DOI: 10.1007/BF00315406
3PMID: 2076714
languageeng
publisherGermany
subjectAdult ; Aged ; Calcium - urine ; Chlorides - urine ; Diuresis - drug effects ; Diuretics - administration & dosage ; Diuretics - pharmacology ; Dose-Response Relationship, Drug ; Electrolytes - urine ; Female ; Humans ; Injections, Intravenous ; Kidney Failure, Chronic - urine ; Magnesium - urine ; Male ; Middle Aged ; Natriuresis - drug effects ; Potassium - urine ; salt ; Sulfonamides - administration & dosage ; Sulfonamides - pharmacokinetics ; Sulfonamides - pharmacology ; torasemide ; Torsemide
ispartofEuropean journal of clinical pharmacology, 1990, Vol.39 (4), p.337-343
lds50peer_reviewed
citesFETCH-LOGICAL-c287t-8e7d2d82337f975831bb1e739c65b5f9057e9e2834dc379287ea690724804c8a0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2076714$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Knauf, H
1Mutschler, E
title
0Saluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion
1European journal of clinical pharmacology
addtitleEur J Clin Pharmacol
descriptionThe effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees. After a control period of 3 days torasemide 20 mg i.v. caused a dramatic increase in diuresis and electrolyte excretion without affecting the glomerular filtration rate. The duration of action of torasemide, tau, averaged 6 h and was independent of the creatinine clearance, CLCR. When related to tau the drug-induced excretion of Cl-, Na+, K+, Ca2+ and Mg2+ showed strong linear dependence on CLCR. Both the kaliuresis and the calciuresis during tau were tightly correlated with the natriuresis over the broad range of CLCR. Similarly, the excretion of Mg2+ was dependent on the kaliuresis. The torasemide-induced kaliuresis amounted to 12% of natriuresis, as after furosemide. The kaliuretic effect of loop diuretics is smaller than that of the thiazides. After tau, e.g. over a 24 h period, kaliuresis was not correlated with natriuresis. The magnitude of the rebound effect was diminished with increasing renal impairment.
subject
0Adult
1Aged
2Calcium - urine
3Chlorides - urine
4Diuresis - drug effects
5Diuretics - administration & dosage
6Diuretics - pharmacology
7Dose-Response Relationship, Drug
8Electrolytes - urine
9Female
10Humans
11Injections, Intravenous
12Kidney Failure, Chronic - urine
13Magnesium - urine
14Male
15Middle Aged
16Natriuresis - drug effects
17Potassium - urine
18salt
19Sulfonamides - administration & dosage
20Sulfonamides - pharmacokinetics
21Sulfonamides - pharmacology
22torasemide
23Torsemide
issn
00031-6970
11432-1041
fulltextfalse
rsrctypearticle
creationdate1990
recordtypearticle
recordideNqFkTFPwzAQRi0EKqWwsCN5YkBKOdtJbI9QUahUiQGYI8e5qEFJXOxEov-eRI1gZDrpu3dvuI-QawZLBiDvH9cAgiUxpCdkzmLBIwYxOyXzMY5SLeGcXITwCcASDWJGZhxkKlk8J-HN1L3HrrIUyxJtR11Jux3S2rk9Lapp1zlvAjZVgbRqqd151w6px9bUtDTVqFjSTduhL3CPbYGtxdGE9aD0rj50SPHbjjLXXpKz0tQBr6a5IB_rp_fVS7R9fd6sHraR5Up2kUJZ8EJxIWSpZaIEy3OGUmibJnlSakgkauRKxIUVUg83aFINkscKYqsMLMjt0bv37qvH0GVNFSzWtWnR9SFTwJUCqf8FWcr48F82gHdH0HoXgscy2_uqMf6QMcjGKrK_Kgb4ZrL2eYPFLzr9Hn4AsGSDkw
startdate1990
enddate1990
creator
0Knauf, H
1Mutschler, E
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
88FD
9FR3
10M7Z
11P64
127X8
sort
creationdate1990
titleSaluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion
authorKnauf, H ; Mutschler, E
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c287t-8e7d2d82337f975831bb1e739c65b5f9057e9e2834dc379287ea690724804c8a0
rsrctypearticles
prefilterarticles
languageeng
creationdate1990
topic
0Adult
1Aged
2Calcium - urine
3Chlorides - urine
4Diuresis - drug effects
5Diuretics - administration & dosage
6Diuretics - pharmacology
7Dose-Response Relationship, Drug
8Electrolytes - urine
9Female
10Humans
11Injections, Intravenous
12Kidney Failure, Chronic - urine
13Magnesium - urine
14Male
15Middle Aged
16Natriuresis - drug effects
17Potassium - urine
18salt
19Sulfonamides - administration & dosage
20Sulfonamides - pharmacokinetics
21Sulfonamides - pharmacology
22torasemide
23Torsemide
toplevelpeer_reviewed
creatorcontrib
0Knauf, H
1Mutschler, E
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Technology Research Database
8Engineering Research Database
9Biochemistry Abstracts 1
10Biotechnology and BioEngineering Abstracts
11MEDLINE - Academic
jtitleEuropean journal of clinical pharmacology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Knauf, H
1Mutschler, E
formatjournal
genrearticle
ristypeJOUR
atitleSaluretic effect of the loop diuretic torasemide in chronic renal failure. Interdependence of electrolyte excretion
jtitleEuropean journal of clinical pharmacology
addtitleEur J Clin Pharmacol
date1990
risdate1990
volume39
issue4
spage337
epage343
pages337-343
issn0031-6970
eissn1432-1041
abstractThe effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees. After a control period of 3 days torasemide 20 mg i.v. caused a dramatic increase in diuresis and electrolyte excretion without affecting the glomerular filtration rate. The duration of action of torasemide, tau, averaged 6 h and was independent of the creatinine clearance, CLCR. When related to tau the drug-induced excretion of Cl-, Na+, K+, Ca2+ and Mg2+ showed strong linear dependence on CLCR. Both the kaliuresis and the calciuresis during tau were tightly correlated with the natriuresis over the broad range of CLCR. Similarly, the excretion of Mg2+ was dependent on the kaliuresis. The torasemide-induced kaliuresis amounted to 12% of natriuresis, as after furosemide. The kaliuretic effect of loop diuretics is smaller than that of the thiazides. After tau, e.g. over a 24 h period, kaliuresis was not correlated with natriuresis. The magnitude of the rebound effect was diminished with increasing renal impairment.
copGermany
pmid2076714
doi10.1007/BF00315406