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Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study

Objective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50... Full description

Journal Title: Cancer causes & control 2010, Vol.21 (12), p.2303-2308
Main Author: Fearnley, Emily J
Other Authors: Marquart, Louise , Spurdle, Amanda B , Weinstein, Philip , Webb, Penelope M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Dordrecht: Springer
ID: ISSN: 0957-5243
Link: https://www.ncbi.nlm.nih.gov/pubmed/20953904
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title: Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study
format: Article
creator:
  • Fearnley, Emily J
  • Marquart, Louise
  • Spurdle, Amanda B
  • Weinstein, Philip
  • Webb, Penelope M
subjects:
  • Acne
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Australia - epidemiology
  • Biomedical and Life Sciences
  • Biomedicine
  • Body mass index
  • Cancer
  • Cancer Research
  • Carcinoma, Endometrioid - epidemiology
  • Carcinoma, Endometrioid - etiology
  • Case-Control Studies
  • Demographic aspects
  • Development and progression
  • Endometrial cancer
  • Endometrial Neoplasms - epidemiology
  • Endometrial Neoplasms - etiology
  • Epidemiology
  • Female
  • general
  • Hematology
  • Hirsutism
  • Histology
  • Humans
  • Medical research
  • Middle Aged
  • Odds Ratio
  • Oncology
  • Oral contraceptives
  • Original Paper
  • Polycystic ovary syndrome
  • Polycystic Ovary Syndrome - complications
  • Polycystic Ovary Syndrome - epidemiology
  • Predisposing factors
  • Public Health
  • Risk Factors
  • Stein-Leventhal syndrome
  • Symptoms
  • Young Adult
ispartof: Cancer causes & control, 2010, Vol.21 (12), p.2303-2308
description: Objective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. Methods Data came from a national population-based case–control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including selfreported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors. Results Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7–9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9–5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk. Conclusions These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.
language: eng
source:
identifier: ISSN: 0957-5243
fulltext: no_fulltext
issn:
  • 0957-5243
  • 1573-7225
url: Link


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titlePolycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study
creatorFearnley, Emily J ; Marquart, Louise ; Spurdle, Amanda B ; Weinstein, Philip ; Webb, Penelope M
creatorcontribFearnley, Emily J ; Marquart, Louise ; Spurdle, Amanda B ; Weinstein, Philip ; Webb, Penelope M ; Australian Ovarian Cancer Study Group and Australian National Endometrial Cancer Study Group ; The Australian Ovarian Cancer Study Group and The Australian National Endometrial Cancer Study Group
descriptionObjective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. Methods Data came from a national population-based case–control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including selfreported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors. Results Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7–9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9–5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk. Conclusions These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.
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subjectAcne ; Adolescent ; Adult ; Age Factors ; Aged ; Australia - epidemiology ; Biomedical and Life Sciences ; Biomedicine ; Body mass index ; Cancer ; Cancer Research ; Carcinoma, Endometrioid - epidemiology ; Carcinoma, Endometrioid - etiology ; Case-Control Studies ; Demographic aspects ; Development and progression ; Endometrial cancer ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - etiology ; Epidemiology ; Female ; general ; Hematology ; Hirsutism ; Histology ; Humans ; Medical research ; Middle Aged ; Odds Ratio ; Oncology ; Oral contraceptives ; Original Paper ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - epidemiology ; Predisposing factors ; Public Health ; Risk Factors ; Stein-Leventhal syndrome ; Symptoms ; Young Adult
ispartofCancer causes & control, 2010, Vol.21 (12), p.2303-2308
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descriptionObjective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. Methods Data came from a national population-based case–control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including selfreported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors. Results Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7–9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9–5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk. Conclusions These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.
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1Marquart, Louise
2Spurdle, Amanda B
3Weinstein, Philip
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atitlePolycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study
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date2010-12-01
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issue12
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pages2303-2308
issn0957-5243
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abstractObjective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. Methods Data came from a national population-based case–control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including selfreported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors. Results Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7–9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9–5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk. Conclusions These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.
copDordrecht
pubSpringer
pmid20953904
doi10.1007/s10552-010-9658-7