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Comparative genomic analysis of simple sequence repeats in three Plasmodium species

Simple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution. To this respect, malaria parasites are known to have rapidly evolving and complex genomes with complicated and differential pathogenic behaviors. Hence, by studying... Full description

Journal Title: Parasitology research (1987) 2010, Vol.108 (2), p.451-458
Main Author: Tyagi, Suchi
Other Authors: Sharma, Meenu , Das, Aparup
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0932-0113
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recordid: cdi_proquest_miscellaneous_846902614
title: Comparative genomic analysis of simple sequence repeats in three Plasmodium species
format: Article
creator:
  • Tyagi, Suchi
  • Sharma, Meenu
  • Das, Aparup
subjects:
  • Animals
  • Biological and medical sciences
  • Biomedical and Life Sciences
  • Biomedicine
  • Chromosome Mapping
  • Comparative Genomic Hybridization
  • Fundamental and applied biological sciences. Psychology
  • General aspects
  • General aspects and techniques. Study of several systematic groups. Models
  • Genes, Protozoan
  • Genetic aspects
  • Genomics
  • Human protozoal diseases
  • Identification and classification
  • Immunology
  • Infectious diseases
  • Invertebrates
  • Malaria
  • Medical Microbiology
  • Medical sciences
  • Microbial genetics
  • Microbiology
  • Microsatellites (Genetics)
  • Minisatellite Repeats - genetics
  • Original Paper
  • Parasitic diseases
  • Plasmodium
  • Plasmodium falciparum - classification
  • Plasmodium falciparum - genetics
  • Plasmodium knowlesi - classification
  • Plasmodium knowlesi - genetics
  • Plasmodium vivax - classification
  • Plasmodium vivax - genetics
  • Protozoal diseases
  • Species Specificity
ispartof: Parasitology research (1987), 2010, Vol.108 (2), p.451-458
description: Simple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution. To this respect, malaria parasites are known to have rapidly evolving and complex genomes with complicated and differential pathogenic behaviors. Hence, by studying the whole genome comparative SSRs patterns, one can understand genomic complexities and differential evolutionary patterns of these species. We herein utilized the whole genome sequence information of three Plasmodium species, Plasmodium falciparum , Plasmodium vivax , and Plasmodium knowlesi , to comparatively analyze genome-wide distribution of SSRs. The study revealed that despite having the smallest genome size, P. falciparum bears the highest SSR content among the three Plasmodium species. Furthermore, distribution patterns of different SSRs types (e.g., mono, di, tri, tetra, penta, and hexa) in term of relative abundance and relative density provide evidences for greater accumulation of di-repeats and marked decrease of mono-repeats in P. falciparum in comparison to other two species. Overall, the types and distribution of SSRs in P. falciparum genome was found to be different than that of P. vivax and P. knowlesi. The latter two species have quite similar SSR organizations in many aspects of the data. The results were discussed in terms of comparative SSR patterns among the three Plasmodium species, uniqueness of P. falciparum in SSR organization and general pattern of evolution of SSRs in Plasmodium .
language: eng
source:
identifier: ISSN: 0932-0113
fulltext: no_fulltext
issn:
  • 0932-0113
  • 1432-1955
url: Link


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titleComparative genomic analysis of simple sequence repeats in three Plasmodium species
creatorTyagi, Suchi ; Sharma, Meenu ; Das, Aparup
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descriptionSimple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution. To this respect, malaria parasites are known to have rapidly evolving and complex genomes with complicated and differential pathogenic behaviors. Hence, by studying the whole genome comparative SSRs patterns, one can understand genomic complexities and differential evolutionary patterns of these species. We herein utilized the whole genome sequence information of three Plasmodium species, Plasmodium falciparum , Plasmodium vivax , and Plasmodium knowlesi , to comparatively analyze genome-wide distribution of SSRs. The study revealed that despite having the smallest genome size, P. falciparum bears the highest SSR content among the three Plasmodium species. Furthermore, distribution patterns of different SSRs types (e.g., mono, di, tri, tetra, penta, and hexa) in term of relative abundance and relative density provide evidences for greater accumulation of di-repeats and marked decrease of mono-repeats in P. falciparum in comparison to other two species. Overall, the types and distribution of SSRs in P. falciparum genome was found to be different than that of P. vivax and P. knowlesi. The latter two species have quite similar SSR organizations in many aspects of the data. The results were discussed in terms of comparative SSR patterns among the three Plasmodium species, uniqueness of P. falciparum in SSR organization and general pattern of evolution of SSRs in Plasmodium .
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languageeng
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subjectAnimals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Chromosome Mapping ; Comparative Genomic Hybridization ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Genes, Protozoan ; Genetic aspects ; Genomics ; Human protozoal diseases ; Identification and classification ; Immunology ; Infectious diseases ; Invertebrates ; Malaria ; Medical Microbiology ; Medical sciences ; Microbial genetics ; Microbiology ; Microsatellites (Genetics) ; Minisatellite Repeats - genetics ; Original Paper ; Parasitic diseases ; Plasmodium ; Plasmodium falciparum - classification ; Plasmodium falciparum - genetics ; Plasmodium knowlesi - classification ; Plasmodium knowlesi - genetics ; Plasmodium vivax - classification ; Plasmodium vivax - genetics ; Protozoal diseases ; Species Specificity
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descriptionSimple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution. To this respect, malaria parasites are known to have rapidly evolving and complex genomes with complicated and differential pathogenic behaviors. Hence, by studying the whole genome comparative SSRs patterns, one can understand genomic complexities and differential evolutionary patterns of these species. We herein utilized the whole genome sequence information of three Plasmodium species, Plasmodium falciparum , Plasmodium vivax , and Plasmodium knowlesi , to comparatively analyze genome-wide distribution of SSRs. The study revealed that despite having the smallest genome size, P. falciparum bears the highest SSR content among the three Plasmodium species. Furthermore, distribution patterns of different SSRs types (e.g., mono, di, tri, tetra, penta, and hexa) in term of relative abundance and relative density provide evidences for greater accumulation of di-repeats and marked decrease of mono-repeats in P. falciparum in comparison to other two species. Overall, the types and distribution of SSRs in P. falciparum genome was found to be different than that of P. vivax and P. knowlesi. The latter two species have quite similar SSR organizations in many aspects of the data. The results were discussed in terms of comparative SSR patterns among the three Plasmodium species, uniqueness of P. falciparum in SSR organization and general pattern of evolution of SSRs in Plasmodium .
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4Chromosome Mapping
5Comparative Genomic Hybridization
6Fundamental and applied biological sciences. Psychology
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8General aspects and techniques. Study of several systematic groups. Models
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10Genetic aspects
11Genomics
12Human protozoal diseases
13Identification and classification
14Immunology
15Infectious diseases
16Invertebrates
17Malaria
18Medical Microbiology
19Medical sciences
20Microbial genetics
21Microbiology
22Microsatellites (Genetics)
23Minisatellite Repeats - genetics
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25Parasitic diseases
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27Plasmodium falciparum - classification
28Plasmodium falciparum - genetics
29Plasmodium knowlesi - classification
30Plasmodium knowlesi - genetics
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33Protozoal diseases
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abstractSimple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution. To this respect, malaria parasites are known to have rapidly evolving and complex genomes with complicated and differential pathogenic behaviors. Hence, by studying the whole genome comparative SSRs patterns, one can understand genomic complexities and differential evolutionary patterns of these species. We herein utilized the whole genome sequence information of three Plasmodium species, Plasmodium falciparum , Plasmodium vivax , and Plasmodium knowlesi , to comparatively analyze genome-wide distribution of SSRs. The study revealed that despite having the smallest genome size, P. falciparum bears the highest SSR content among the three Plasmodium species. Furthermore, distribution patterns of different SSRs types (e.g., mono, di, tri, tetra, penta, and hexa) in term of relative abundance and relative density provide evidences for greater accumulation of di-repeats and marked decrease of mono-repeats in P. falciparum in comparison to other two species. Overall, the types and distribution of SSRs in P. falciparum genome was found to be different than that of P. vivax and P. knowlesi. The latter two species have quite similar SSR organizations in many aspects of the data. The results were discussed in terms of comparative SSR patterns among the three Plasmodium species, uniqueness of P. falciparum in SSR organization and general pattern of evolution of SSRs in Plasmodium .
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doi10.1007/s00436-010-2086-5