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Quantitative CT measures of emphysema and airway wall thickness are related to D(L)CO

There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airw... Full description

Journal Title: Respiratory medicine 2011, Vol.105 (3), p.343-351
Main Author: Grydeland, Thomas B
Other Authors: Thorsen, Einar , Dirksen, Asger , Jensen, Robert , Coxson, Harvey O , Pillai, Sreekumar G , Sharma, Sanjay , Eide, Geir Egil , Gulsvik, Amund , Bakke, Per S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England
ID: EISSN: 1532-3064
Link: https://www.ncbi.nlm.nih.gov/pubmed/21074394
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recordid: cdi_proquest_miscellaneous_847434393
title: Quantitative CT measures of emphysema and airway wall thickness are related to D(L)CO
format: Article
creator:
  • Grydeland, Thomas B
  • Thorsen, Einar
  • Dirksen, Asger
  • Jensen, Robert
  • Coxson, Harvey O
  • Pillai, Sreekumar G
  • Sharma, Sanjay
  • Eide, Geir Egil
  • Gulsvik, Amund
  • Bakke, Per S
subjects:
  • Analysis of Variance
  • Carbon Monoxide - metabolism
  • Female
  • Humans
  • Linear Models
  • Lung - diagnostic imaging
  • Lung - pathology
  • Lung - physiopathology
  • Male
  • Middle Aged
  • Pulmonary Diffusing Capacity - methods
  • Pulmonary Disease, Chronic Obstructive - diagnostic imaging
  • Pulmonary Disease, Chronic Obstructive - pathology
  • Pulmonary Disease, Chronic Obstructive - physiopathology
  • Pulmonary Emphysema - diagnostic imaging
  • Pulmonary Emphysema - pathology
  • Pulmonary Emphysema - physiopathology
  • Spirometry
  • Tomography, X-Ray Computed
ispartof: Respiratory medicine, 2011, Vol.105 (3), p.343-351
description: There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas < -950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D(L)CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D(L)CO (mmol min(-1) kPa(-1)) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R(2) was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D(L)CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D(L)CO, but explains a much smaller fraction of the variation.
language: eng
source: Alma/SFX Local Collection
identifier: EISSN: 1532-3064
fulltext: fulltext
issn:
  • 1532-3064
url: Link


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descriptionThere is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas < -950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D(L)CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D(L)CO (mmol min(-1) kPa(-1)) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R(2) was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D(L)CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D(L)CO, but explains a much smaller fraction of the variation.
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subjectAnalysis of Variance ; Carbon Monoxide - metabolism ; Female ; Humans ; Linear Models ; Lung - diagnostic imaging ; Lung - pathology ; Lung - physiopathology ; Male ; Middle Aged ; Pulmonary Diffusing Capacity - methods ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Emphysema - diagnostic imaging ; Pulmonary Emphysema - pathology ; Pulmonary Emphysema - physiopathology ; Spirometry ; Tomography, X-Ray Computed
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descriptionThere is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas < -950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D(L)CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D(L)CO (mmol min(-1) kPa(-1)) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R(2) was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D(L)CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D(L)CO, but explains a much smaller fraction of the variation.
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abstractThere is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas < -950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D(L)CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D(L)CO (mmol min(-1) kPa(-1)) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R(2) was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D(L)CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D(L)CO, but explains a much smaller fraction of the variation.
copEngland
pmid21074394
doi10.1016/j.rmed.2010.10.018