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Zebrafish in endocrine systems: recent advances and implications for human disease

Since its introduction as a genetic vertebrate model system approximately 30 years ago, the focus of zebrafish research has increasingly shifted to questions that are also relevant for human development and disease. Here, we review the potential of the zebrafish as a model for human endocrine system... Full description

Journal Title: Annual review of physiology 2011, Vol.73 (1), p.183-211
Main Author: Löhr, Heiko
Other Authors: Hammerschmidt, Matthias
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0066-4278
Link: https://www.ncbi.nlm.nih.gov/pubmed/21314433
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recordid: cdi_proquest_miscellaneous_851749182
title: Zebrafish in endocrine systems: recent advances and implications for human disease
format: Article
creator:
  • Löhr, Heiko
  • Hammerschmidt, Matthias
subjects:
  • Adipose Tissue - anatomy & histology
  • Adipose Tissue - physiology
  • Animals
  • Calcium - physiology
  • Circadian Rhythm - physiology
  • Comparative analysis
  • Disease
  • Disease Models, Animal
  • Endocrine system
  • Endocrine System - physiology
  • Female
  • Genetics
  • Gonadal Hormones - physiology
  • Homeostasis
  • Homeostasis - physiology
  • Human growth
  • Humans
  • Hypothalamo-Hypophyseal System - anatomy & histology
  • Hypothalamo-Hypophyseal System - physiology
  • Lipid Metabolism - physiology
  • Male
  • Models
  • Physiology
  • Pituitary-Adrenal System - physiology
  • Reproduction - physiology
  • Research
  • Signal Transduction - physiology
  • Sleep - physiology
  • Stress, Physiological - physiology
  • Vertebrates
  • Water-Electrolyte Balance - physiology
  • Zebra fish
  • Zebrafish
  • Zebrafish - genetics
  • Zebrafish - growth & development
  • Zebrafish - physiology
ispartof: Annual review of physiology, 2011, Vol.73 (1), p.183-211
description: Since its introduction as a genetic vertebrate model system approximately 30 years ago, the focus of zebrafish research has increasingly shifted to questions that are also relevant for human development and disease. Here, we review the potential of the zebrafish as a model for human endocrine systems. A recent review compared the functions of the different endocrine systems and glands in zebrafish with those in other vertebrates, including humans, coming to the conclusion that major aspects are conserved. Here, we present an updated overview of this rapidly growing field of zebrafish research, focusing on the hypothalamo-pituitary axis, which links the central nervous system with the endocrine systems, and on major processes that are under (neuro)endocrine control and are the subject of intensive current research in other endocrine model organisms, such as feeding circuits and energy homeostasis, sleep, stress, reproduction, osmoregulation, and calcium homeostasis. Finally, we summarize the strengths and weaknesses of zebrafish as a model for studying endocrine systems.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4278
fulltext: fulltext
issn:
  • 0066-4278
  • 1545-1585
url: Link


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descriptionSince its introduction as a genetic vertebrate model system approximately 30 years ago, the focus of zebrafish research has increasingly shifted to questions that are also relevant for human development and disease. Here, we review the potential of the zebrafish as a model for human endocrine systems. A recent review compared the functions of the different endocrine systems and glands in zebrafish with those in other vertebrates, including humans, coming to the conclusion that major aspects are conserved. Here, we present an updated overview of this rapidly growing field of zebrafish research, focusing on the hypothalamo-pituitary axis, which links the central nervous system with the endocrine systems, and on major processes that are under (neuro)endocrine control and are the subject of intensive current research in other endocrine model organisms, such as feeding circuits and energy homeostasis, sleep, stress, reproduction, osmoregulation, and calcium homeostasis. Finally, we summarize the strengths and weaknesses of zebrafish as a model for studying endocrine systems.
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subjectAdipose Tissue - anatomy & histology ; Adipose Tissue - physiology ; Animals ; Calcium - physiology ; Circadian Rhythm - physiology ; Comparative analysis ; Disease ; Disease Models, Animal ; Endocrine system ; Endocrine System - physiology ; Female ; Genetics ; Gonadal Hormones - physiology ; Homeostasis ; Homeostasis - physiology ; Human growth ; Humans ; Hypothalamo-Hypophyseal System - anatomy & histology ; Hypothalamo-Hypophyseal System - physiology ; Lipid Metabolism - physiology ; Male ; Models ; Physiology ; Pituitary-Adrenal System - physiology ; Reproduction - physiology ; Research ; Signal Transduction - physiology ; Sleep - physiology ; Stress, Physiological - physiology ; Vertebrates ; Water-Electrolyte Balance - physiology ; Zebra fish ; Zebrafish ; Zebrafish - genetics ; Zebrafish - growth & development ; Zebrafish - physiology
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abstractSince its introduction as a genetic vertebrate model system approximately 30 years ago, the focus of zebrafish research has increasingly shifted to questions that are also relevant for human development and disease. Here, we review the potential of the zebrafish as a model for human endocrine systems. A recent review compared the functions of the different endocrine systems and glands in zebrafish with those in other vertebrates, including humans, coming to the conclusion that major aspects are conserved. Here, we present an updated overview of this rapidly growing field of zebrafish research, focusing on the hypothalamo-pituitary axis, which links the central nervous system with the endocrine systems, and on major processes that are under (neuro)endocrine control and are the subject of intensive current research in other endocrine model organisms, such as feeding circuits and energy homeostasis, sleep, stress, reproduction, osmoregulation, and calcium homeostasis. Finally, we summarize the strengths and weaknesses of zebrafish as a model for studying endocrine systems.
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