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Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population

BackgroundDyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.ObjectiveTo identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.Methods21 single nuc... Full description

Journal Title: Journal of medical genetics 2011, Vol.48 (1), p.10-15
Main Author: Park, Mi-Hyun
Other Authors: Kim, NamHee , Lee, Jong-Young , Park, Hyun-Young
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0022-2593
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title: Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population
format: Article
creator:
  • Park, Mi-Hyun
  • Kim, NamHee
  • Lee, Jong-Young
  • Park, Hyun-Young
subjects:
  • Asian Continental Ancestry Group - genetics
  • association
  • Atherosclerosis (general aspects, experimental research)
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Blood lipids
  • Cardiology. Vascular system
  • Cardiovascular disease
  • Cardiovascular diseases
  • Cardiovascular Diseases - blood
  • Cardiovascular Diseases - genetics
  • cardiovascular medicine
  • Cholesterol, HDL - blood
  • Cholesterol, HDL - genetics
  • Cholesterol, LDL - blood
  • Cholesterol, LDL - genetics
  • clinical genetics
  • Demographic aspects
  • Fundamental and applied biological sciences. Psychology
  • Genes
  • Genetic aspects
  • Genetic Loci - genetics
  • Genetic Predisposition to Disease
  • genetics
  • Genetics of eukaryotes. Biological and molecular evolution
  • Humans
  • Identification and classification
  • Insulin resistance
  • Lipid
  • lipid disorders
  • Lipids - blood
  • Lipids - genetics
  • Low density lipoprotein
  • Medical genetics
  • Medical sciences
  • Middle Aged
  • Molecular and cellular biology
  • Polymorphism, Single Nucleotide - genetics
  • Quantitative trait loci
  • Quantitative Trait, Heritable
  • Republic of Korea - ethnology
  • Risk Factors
  • Rodents
  • Single nucleotide polymorphisms
  • Triglycerides - blood
  • Triglycerides - genetics
ispartof: Journal of medical genetics, 2011, Vol.48 (1), p.10-15
description: BackgroundDyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.ObjectiveTo identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.Methods21 single nucleotide polymorphisms (SNPs) that have been reported as associated with lipid concentrations in people of European ancestry were selected and their associations with CVD risk factors in Korean populations assessed. Genotype data from 7616 subjects without diabetes or lipid-lowering drugs were obtained from the Korean Association Resource (KARE) project.ResultsAfter adjustment for age and gender, five SNPs were identified that were associated with high-density lipoprotein-cholesterol (HDL-C; rs4420638: p=2.09×10-7), 11 SNPs with low-density lipoprotein-cholesterol (LDL-C; rs12654264: p=1.29×10-8) and eight SNPs with triglycerides (TG; rs4420638: p=1.80×10-6). Through analysis of multiple associations with lipid traits, after adjustment for age, gender, body mass index, smoking, alcohol consumption and hypertension, five SNPs (rs693, rs17321515, rs174547, rs688, rs4420638) were identified that were strongly associated with at least two of the following: HDL-C, LDL-C and TG. Of these, rs693, which lies in the APOB gene, was also significantly associated with the homoeostasis model assessment for insulin resistance (p=6.68×10-6) and γ-glutamyl transpeptidase (p=2.34×10-6), and rs174547, which lies in the FADS1 gene and was significantly associated with fasting plasma glucose (p=1.48×10-6).ConclusionSeveral SNPs associated with lipid traits and CVD risk factors were identified. These findings may form the basis for further investigations to identify the causative polymorphisms in dyslipidaemia and CVD.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0022-2593
fulltext: fulltext
issn:
  • 0022-2593
  • 1468-6244
  • 1468-6244
url: Link


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titleGenetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population
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creatorPark, Mi-Hyun ; Kim, NamHee ; Lee, Jong-Young ; Park, Hyun-Young
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descriptionBackgroundDyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.ObjectiveTo identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.Methods21 single nucleotide polymorphisms (SNPs) that have been reported as associated with lipid concentrations in people of European ancestry were selected and their associations with CVD risk factors in Korean populations assessed. Genotype data from 7616 subjects without diabetes or lipid-lowering drugs were obtained from the Korean Association Resource (KARE) project.ResultsAfter adjustment for age and gender, five SNPs were identified that were associated with high-density lipoprotein-cholesterol (HDL-C; rs4420638: p=2.09×10-7), 11 SNPs with low-density lipoprotein-cholesterol (LDL-C; rs12654264: p=1.29×10-8) and eight SNPs with triglycerides (TG; rs4420638: p=1.80×10-6). Through analysis of multiple associations with lipid traits, after adjustment for age, gender, body mass index, smoking, alcohol consumption and hypertension, five SNPs (rs693, rs17321515, rs174547, rs688, rs4420638) were identified that were strongly associated with at least two of the following: HDL-C, LDL-C and TG. Of these, rs693, which lies in the APOB gene, was also significantly associated with the homoeostasis model assessment for insulin resistance (p=6.68×10-6) and γ-glutamyl transpeptidase (p=2.34×10-6), and rs174547, which lies in the FADS1 gene and was significantly associated with fasting plasma glucose (p=1.48×10-6).ConclusionSeveral SNPs associated with lipid traits and CVD risk factors were identified. These findings may form the basis for further investigations to identify the causative polymorphisms in dyslipidaemia and CVD.
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languageeng
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subjectAsian Continental Ancestry Group - genetics ; association ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood lipids ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; cardiovascular medicine ; Cholesterol, HDL - blood ; Cholesterol, HDL - genetics ; Cholesterol, LDL - blood ; Cholesterol, LDL - genetics ; clinical genetics ; Demographic aspects ; Fundamental and applied biological sciences. Psychology ; Genes ; Genetic aspects ; Genetic Loci - genetics ; Genetic Predisposition to Disease ; genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Humans ; Identification and classification ; Insulin resistance ; Lipid ; lipid disorders ; Lipids - blood ; Lipids - genetics ; Low density lipoprotein ; Medical genetics ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Polymorphism, Single Nucleotide - genetics ; Quantitative trait loci ; Quantitative Trait, Heritable ; Republic of Korea - ethnology ; Risk Factors ; Rodents ; Single nucleotide polymorphisms ; Triglycerides - blood ; Triglycerides - genetics
ispartofJournal of medical genetics, 2011, Vol.48 (1), p.10-15
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descriptionBackgroundDyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.ObjectiveTo identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.Methods21 single nucleotide polymorphisms (SNPs) that have been reported as associated with lipid concentrations in people of European ancestry were selected and their associations with CVD risk factors in Korean populations assessed. Genotype data from 7616 subjects without diabetes or lipid-lowering drugs were obtained from the Korean Association Resource (KARE) project.ResultsAfter adjustment for age and gender, five SNPs were identified that were associated with high-density lipoprotein-cholesterol (HDL-C; rs4420638: p=2.09×10-7), 11 SNPs with low-density lipoprotein-cholesterol (LDL-C; rs12654264: p=1.29×10-8) and eight SNPs with triglycerides (TG; rs4420638: p=1.80×10-6). Through analysis of multiple associations with lipid traits, after adjustment for age, gender, body mass index, smoking, alcohol consumption and hypertension, five SNPs (rs693, rs17321515, rs174547, rs688, rs4420638) were identified that were strongly associated with at least two of the following: HDL-C, LDL-C and TG. Of these, rs693, which lies in the APOB gene, was also significantly associated with the homoeostasis model assessment for insulin resistance (p=6.68×10-6) and γ-glutamyl transpeptidase (p=2.34×10-6), and rs174547, which lies in the FADS1 gene and was significantly associated with fasting plasma glucose (p=1.48×10-6).ConclusionSeveral SNPs associated with lipid traits and CVD risk factors were identified. These findings may form the basis for further investigations to identify the causative polymorphisms in dyslipidaemia and CVD.
subject
0Asian Continental Ancestry Group - genetics
1association
2Atherosclerosis (general aspects, experimental research)
3Biological and medical sciences
4Blood and lymphatic vessels
5Blood lipids
6Cardiology. Vascular system
7Cardiovascular disease
8Cardiovascular diseases
9Cardiovascular Diseases - blood
10Cardiovascular Diseases - genetics
11cardiovascular medicine
12Cholesterol, HDL - blood
13Cholesterol, HDL - genetics
14Cholesterol, LDL - blood
15Cholesterol, LDL - genetics
16clinical genetics
17Demographic aspects
18Fundamental and applied biological sciences. Psychology
19Genes
20Genetic aspects
21Genetic Loci - genetics
22Genetic Predisposition to Disease
23genetics
24Genetics of eukaryotes. Biological and molecular evolution
25Humans
26Identification and classification
27Insulin resistance
28Lipid
29lipid disorders
30Lipids - blood
31Lipids - genetics
32Low density lipoprotein
33Medical genetics
34Medical sciences
35Middle Aged
36Molecular and cellular biology
37Polymorphism, Single Nucleotide - genetics
38Quantitative trait loci
39Quantitative Trait, Heritable
40Republic of Korea - ethnology
41Risk Factors
42Rodents
43Single nucleotide polymorphisms
44Triglycerides - blood
45Triglycerides - genetics
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1association
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4Blood and lymphatic vessels
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abstractBackgroundDyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.ObjectiveTo identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.Methods21 single nucleotide polymorphisms (SNPs) that have been reported as associated with lipid concentrations in people of European ancestry were selected and their associations with CVD risk factors in Korean populations assessed. Genotype data from 7616 subjects without diabetes or lipid-lowering drugs were obtained from the Korean Association Resource (KARE) project.ResultsAfter adjustment for age and gender, five SNPs were identified that were associated with high-density lipoprotein-cholesterol (HDL-C; rs4420638: p=2.09×10-7), 11 SNPs with low-density lipoprotein-cholesterol (LDL-C; rs12654264: p=1.29×10-8) and eight SNPs with triglycerides (TG; rs4420638: p=1.80×10-6). Through analysis of multiple associations with lipid traits, after adjustment for age, gender, body mass index, smoking, alcohol consumption and hypertension, five SNPs (rs693, rs17321515, rs174547, rs688, rs4420638) were identified that were strongly associated with at least two of the following: HDL-C, LDL-C and TG. Of these, rs693, which lies in the APOB gene, was also significantly associated with the homoeostasis model assessment for insulin resistance (p=6.68×10-6) and γ-glutamyl transpeptidase (p=2.34×10-6), and rs174547, which lies in the FADS1 gene and was significantly associated with fasting plasma glucose (p=1.48×10-6).ConclusionSeveral SNPs associated with lipid traits and CVD risk factors were identified. These findings may form the basis for further investigations to identify the causative polymorphisms in dyslipidaemia and CVD.
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pubBMJ Publishing Group Ltd
pmid20972250
doi10.1136/jmg.2010.081000