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Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease

Albuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been refe... Full description

Journal Title: The American journal of cardiology 2011, Vol.107 (8), p.1144-1148
Main Author: Rein, Philipp, MD
Other Authors: Vonbank, Alexander, MD , Saely, Christoph H., MD , Beer, Stefan, MD , Jankovic, Vlado, MD , Boehnel, Christian, MD , Breuss, Johannes, MD , Risch, Lorenz, MD , Fraunberger, Peter, MD , Drexel, Heinz, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
ACE inhibitors
Aged
Albuminuria - epidemiology
Albuminuria - etiology
Albuminuria - physiopathology
Atherosclerosis
Austria - epidemiology
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Coronary Angiography
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Coronary heart disease
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Follow-Up Studies
Glomerular Filtration Rate - physiology
Heart
Humans
Male
Medical imaging
Medical sciences
Middle Aged
Mortality
Prevalence
Regression analysis
Retrospective Studies
Risk Factors
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
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recordid: cdi_proquest_miscellaneous_860187299
title: Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
format: Article
creator:
  • Rein, Philipp, MD
  • Vonbank, Alexander, MD
  • Saely, Christoph H., MD
  • Beer, Stefan, MD
  • Jankovic, Vlado, MD
  • Boehnel, Christian, MD
  • Breuss, Johannes, MD
  • Risch, Lorenz, MD
  • Fraunberger, Peter, MD
  • Drexel, Heinz, MD
subjects:
  • Abridged Index Medicus
  • ACE inhibitors
  • Aged
  • Albuminuria - epidemiology
  • Albuminuria - etiology
  • Albuminuria - physiopathology
  • Atherosclerosis
  • Austria - epidemiology
  • Biological and medical sciences
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • Coronary Angiography
  • Coronary Artery Disease - complications
  • Coronary Artery Disease - diagnostic imaging
  • Coronary Artery Disease - physiopathology
  • Coronary heart disease
  • Diabetes
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate - physiology
  • Heart
  • Humans
  • Male
  • Medical imaging
  • Medical sciences
  • Middle Aged
  • Mortality
  • Prevalence
  • Regression analysis
  • Retrospective Studies
  • Risk Factors
ispartof: The American journal of cardiology, 2011, Vol.107 (8), p.1144-1148
description: Albuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleRelation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
creatorRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
creatorcontribRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
descriptionAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
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0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/j.amjcard.2010.12.011
3PMID: 21324429
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; ACE inhibitors ; Aged ; Albuminuria - epidemiology ; Albuminuria - etiology ; Albuminuria - physiopathology ; Atherosclerosis ; Austria - epidemiology ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Coronary Angiography ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - physiopathology ; Coronary heart disease ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Glomerular Filtration Rate - physiology ; Heart ; Humans ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Mortality ; Prevalence ; Regression analysis ; Retrospective Studies ; Risk Factors
ispartofThe American journal of cardiology, 2011, Vol.107 (8), p.1144-1148
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1Vonbank, Alexander, MD
2Saely, Christoph H., MD
3Beer, Stefan, MD
4Jankovic, Vlado, MD
5Boehnel, Christian, MD
6Breuss, Johannes, MD
7Risch, Lorenz, MD
8Fraunberger, Peter, MD
9Drexel, Heinz, MD
title
0Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
1The American journal of cardiology
addtitleAm J Cardiol
descriptionAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
subject
0Abridged Index Medicus
1ACE inhibitors
2Aged
3Albuminuria - epidemiology
4Albuminuria - etiology
5Albuminuria - physiopathology
6Atherosclerosis
7Austria - epidemiology
8Biological and medical sciences
9Cardiology. Vascular system
10Cardiovascular
11Cardiovascular disease
12Coronary Angiography
13Coronary Artery Disease - complications
14Coronary Artery Disease - diagnostic imaging
15Coronary Artery Disease - physiopathology
16Coronary heart disease
17Diabetes
18Diabetes Mellitus, Type 2 - complications
19Diabetes Mellitus, Type 2 - physiopathology
20Diabetes. Impaired glucose tolerance
21Endocrine pancreas. Apud cells (diseases)
22Endocrinopathies
23Etiopathogenesis. Screening. Investigations. Target tissue resistance
24Female
25Follow-Up Studies
26Glomerular Filtration Rate - physiology
27Heart
28Humans
29Male
30Medical imaging
31Medical sciences
32Middle Aged
33Mortality
34Prevalence
35Regression analysis
36Retrospective Studies
37Risk Factors
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5Boehnel, Christian, MD
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7Risch, Lorenz, MD
8Fraunberger, Peter, MD
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titleRelation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
authorRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
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0Abridged Index Medicus
1ACE inhibitors
2Aged
3Albuminuria - epidemiology
4Albuminuria - etiology
5Albuminuria - physiopathology
6Atherosclerosis
7Austria - epidemiology
8Biological and medical sciences
9Cardiology. Vascular system
10Cardiovascular
11Cardiovascular disease
12Coronary Angiography
13Coronary Artery Disease - complications
14Coronary Artery Disease - diagnostic imaging
15Coronary Artery Disease - physiopathology
16Coronary heart disease
17Diabetes
18Diabetes Mellitus, Type 2 - complications
19Diabetes Mellitus, Type 2 - physiopathology
20Diabetes. Impaired glucose tolerance
21Endocrine pancreas. Apud cells (diseases)
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25Follow-Up Studies
26Glomerular Filtration Rate - physiology
27Heart
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29Male
30Medical imaging
31Medical sciences
32Middle Aged
33Mortality
34Prevalence
35Regression analysis
36Retrospective Studies
37Risk Factors
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jtitleThe American journal of cardiology
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issn0002-9149
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abstractAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
copNew York, NY
pubElsevier Inc
pmid21324429
doi10.1016/j.amjcard.2010.12.011