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Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease

Albuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been refe... Full description

Journal Title: The American journal of cardiology 2011, Vol.107 (8), p.1144-1148
Main Author: Rein, Philipp, MD
Other Authors: Vonbank, Alexander, MD , Saely, Christoph H., MD , Beer, Stefan, MD , Jankovic, Vlado, MD , Boehnel, Christian, MD , Breuss, Johannes, MD , Risch, Lorenz, MD , Fraunberger, Peter, MD , Drexel, Heinz, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
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title: Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
format: Article
creator:
  • Rein, Philipp, MD
  • Vonbank, Alexander, MD
  • Saely, Christoph H., MD
  • Beer, Stefan, MD
  • Jankovic, Vlado, MD
  • Boehnel, Christian, MD
  • Breuss, Johannes, MD
  • Risch, Lorenz, MD
  • Fraunberger, Peter, MD
  • Drexel, Heinz, MD
subjects:
  • Abridged Index Medicus
  • ACE inhibitors
  • Aged
  • Albuminuria - epidemiology
  • Albuminuria - etiology
  • Albuminuria - physiopathology
  • Atherosclerosis
  • Austria - epidemiology
  • Biological and medical sciences
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • Coronary Angiography
  • Coronary Artery Disease - complications
  • Coronary Artery Disease - diagnostic imaging
  • Coronary Artery Disease - physiopathology
  • Coronary heart disease
  • Diabetes
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate - physiology
  • Heart
  • Humans
  • Male
  • Medical imaging
  • Medical sciences
  • Middle Aged
  • Mortality
  • Prevalence
  • Regression analysis
  • Retrospective Studies
  • Risk Factors
ispartof: The American journal of cardiology, 2011, Vol.107 (8), p.1144-1148
description: Albuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleRelation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
creatorRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
creatorcontribRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
descriptionAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
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1EISSN: 1879-1913
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3PMID: 21324429
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; ACE inhibitors ; Aged ; Albuminuria - epidemiology ; Albuminuria - etiology ; Albuminuria - physiopathology ; Atherosclerosis ; Austria - epidemiology ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Coronary Angiography ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - physiopathology ; Coronary heart disease ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Glomerular Filtration Rate - physiology ; Heart ; Humans ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Mortality ; Prevalence ; Regression analysis ; Retrospective Studies ; Risk Factors
ispartofThe American journal of cardiology, 2011, Vol.107 (8), p.1144-1148
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1Vonbank, Alexander, MD
2Saely, Christoph H., MD
3Beer, Stefan, MD
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5Boehnel, Christian, MD
6Breuss, Johannes, MD
7Risch, Lorenz, MD
8Fraunberger, Peter, MD
9Drexel, Heinz, MD
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0Relation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
1The American journal of cardiology
addtitleAm J Cardiol
descriptionAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
subject
0Abridged Index Medicus
1ACE inhibitors
2Aged
3Albuminuria - epidemiology
4Albuminuria - etiology
5Albuminuria - physiopathology
6Atherosclerosis
7Austria - epidemiology
8Biological and medical sciences
9Cardiology. Vascular system
10Cardiovascular
11Cardiovascular disease
12Coronary Angiography
13Coronary Artery Disease - complications
14Coronary Artery Disease - diagnostic imaging
15Coronary Artery Disease - physiopathology
16Coronary heart disease
17Diabetes
18Diabetes Mellitus, Type 2 - complications
19Diabetes Mellitus, Type 2 - physiopathology
20Diabetes. Impaired glucose tolerance
21Endocrine pancreas. Apud cells (diseases)
22Endocrinopathies
23Etiopathogenesis. Screening. Investigations. Target tissue resistance
24Female
25Follow-Up Studies
26Glomerular Filtration Rate - physiology
27Heart
28Humans
29Male
30Medical imaging
31Medical sciences
32Middle Aged
33Mortality
34Prevalence
35Regression analysis
36Retrospective Studies
37Risk Factors
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4Jankovic, Vlado, MD
5Boehnel, Christian, MD
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7Risch, Lorenz, MD
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titleRelation of Albuminuria to Angiographically Determined Coronary Arterial Narrowing in Patients With and Without Type 2 Diabetes Mellitus and Stable or Suspected Coronary Artery Disease
authorRein, Philipp, MD ; Vonbank, Alexander, MD ; Saely, Christoph H., MD ; Beer, Stefan, MD ; Jankovic, Vlado, MD ; Boehnel, Christian, MD ; Breuss, Johannes, MD ; Risch, Lorenz, MD ; Fraunberger, Peter, MD ; Drexel, Heinz, MD
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1ACE inhibitors
2Aged
3Albuminuria - epidemiology
4Albuminuria - etiology
5Albuminuria - physiopathology
6Atherosclerosis
7Austria - epidemiology
8Biological and medical sciences
9Cardiology. Vascular system
10Cardiovascular
11Cardiovascular disease
12Coronary Angiography
13Coronary Artery Disease - complications
14Coronary Artery Disease - diagnostic imaging
15Coronary Artery Disease - physiopathology
16Coronary heart disease
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19Diabetes Mellitus, Type 2 - physiopathology
20Diabetes. Impaired glucose tolerance
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26Glomerular Filtration Rate - physiology
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29Male
30Medical imaging
31Medical sciences
32Middle Aged
33Mortality
34Prevalence
35Regression analysis
36Retrospective Studies
37Risk Factors
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jtitleThe American journal of cardiology
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abstractAlbuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner. The present study included 914 consecutive white patients who had been referred for coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 μg/mg. Microalbuminuria was defined as 30 to 300 μg albumin/mg creatinine, and macroalbuminuria as a urinary albumin/creatinine ratio of ≥300 μg/mg. The prevalence of stenoses of ≥50% was significantly greater in patients with albuminuria than in those with normoalbuminuria (66% vs 51%; p <0.001). Logistic regression analysis, adjusted for age, gender, diabetes, smoking, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, body mass index, estimated glomerular filtration rate, and the use of angiotensin-converting enzyme inhibitors/angiotensin II antagonists, aspirin, and statins, confirmed that albuminuria was significantly associated with stenoses ≥50% (standardized adjusted odds ratio [OR] 1.68, 95% confidence interval [CI] 1.15 to 2.44; p = 0.007). The adjusted OR was 1.54 (95% CI 1.03 to 2.30; p = 0.034) for microalbuminuria and 2.55 (95% CI 1.14 to 5.72; p = 0.023) for macroalbuminuria. This association was significant in the subgroup of patients with type 2 diabetes (OR 1.66, 95% CI 1.01 to 2.74; p = 0.045) and in those without diabetes (OR 1.42, 95% CI 1.05 to 1.92; p = 0.023). An interaction term urinary albumin/creatinine ratio*diabetes was not significant (p = 0.579). In conclusion, micro- and macroalbuminuria were strongly associated with angiographically determined coronary atherosclerosis in both patients with and those without type 2 diabetes mellitus, independent of conventional cardiovascular risk factors and the estimated glomerular filtration rate.
copNew York, NY
pubElsevier Inc
pmid21324429
doi10.1016/j.amjcard.2010.12.011