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HNO Signaling Mechanisms

Due to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear th... Full description

Journal Title: Antioxidants & redox signaling 2011-05-01, Vol.14 (9), p.1649-1657
Main Author: Fukuto, Jon M.
Other Authors: Carrington, Samantha J.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1523-0864
Link: https://www.ncbi.nlm.nih.gov/pubmed/21235348
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title: HNO Signaling Mechanisms
format: Article
creator:
  • Fukuto, Jon M.
  • Carrington, Samantha J.
subjects:
  • Animals
  • Cellular signal transduction
  • Forum Review Articles
  • Health aspects
  • Humans
  • Metalloproteins - chemistry
  • Metalloproteins - metabolism
  • Nitrogen oxide
  • Nitrogen Oxides - chemistry
  • Nitrogen Oxides - metabolism
  • Protein-protein interactions
  • Signal Transduction
  • Sulfhydryl Compounds - chemistry
  • Sulfhydryl Compounds - metabolism
  • Thiols
ispartof: Antioxidants & redox signaling, 2011-05-01, Vol.14 (9), p.1649-1657
description: Due to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism. Antioxid. Redox Signal. 14, 1649–1657.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1523-0864
fulltext: fulltext
issn:
  • 1523-0864
  • 1557-7716
url: Link


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descriptionDue to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism. Antioxid. Redox Signal. 14, 1649–1657.
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subjectAnimals ; Cellular signal transduction ; Forum Review Articles ; Health aspects ; Humans ; Metalloproteins - chemistry ; Metalloproteins - metabolism ; Nitrogen oxide ; Nitrogen Oxides - chemistry ; Nitrogen Oxides - metabolism ; Protein-protein interactions ; Signal Transduction ; Sulfhydryl Compounds - chemistry ; Sulfhydryl Compounds - metabolism ; Thiols
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abstractDue to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism. Antioxid. Redox Signal. 14, 1649–1657.
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doi10.1089/ars.2010.3855