schliessen

Filtern

 

Bibliotheken

Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer

Endocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we repor... Full description

Journal Title: Nature medicine 2011-06, Vol.17 (6), p.708-714
Main Author: Pan, Xin
Other Authors: Zhou, Tao , Tai, Yan-Hong , Wang, Chenguang , Zhao, Jie , Cao, Yuan , Chen, Yuan , Zhang, Pei-Jing , Yu, Ming , Zhen, Cheng , Mu, Rui , Bai, Zhao-Fang , Li, Hui-Yan , Li, Ai-Ling , Liang, Bing , Jian, Zhao , Zhang, Wei-Na , Man, Jiang-Hong , Gao, Yan-Fei , Gong, Wei-Li , Wei, Li-Xin , Zhang, Xue-Min
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/21572428
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_871003753
title: Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
format: Article
creator:
  • Pan, Xin
  • Zhou, Tao
  • Tai, Yan-Hong
  • Wang, Chenguang
  • Zhao, Jie
  • Cao, Yuan
  • Chen, Yuan
  • Zhang, Pei-Jing
  • Yu, Ming
  • Zhen, Cheng
  • Mu, Rui
  • Bai, Zhao-Fang
  • Li, Hui-Yan
  • Li, Ai-Ling
  • Liang, Bing
  • Jian, Zhao
  • Zhang, Wei-Na
  • Man, Jiang-Hong
  • Gao, Yan-Fei
  • Gong, Wei-Li
  • Wei, Li-Xin
  • Zhang, Xue-Min
subjects:
  • Antineoplastic Agents, Hormonal - therapeutic use
  • Breast cancer
  • Breast Neoplasms - drug therapy
  • Breast Neoplasms - physiopathology
  • Care and treatment
  • Carrier Proteins - biosynthesis
  • Carrier Proteins - physiology
  • Cell Line, Tumor
  • Down-Regulation
  • Drug Resistance, Neoplasm - physiology
  • Endocrine therapy
  • Estrogen Receptor alpha - metabolism
  • Estrogen Receptor alpha - physiology
  • Estrogens
  • Female
  • Gene expression
  • Gene Expression Regulation, Neoplastic - physiology
  • Genetic aspects
  • Health aspects
  • Hormone therapy
  • Humans
  • I-kappa B Kinase - metabolism
  • I-kappa B Kinase - physiology
  • Membrane Proteins - biosynthesis
  • Membrane Proteins - physiology
  • Phosphorylation
  • Proteins
  • Receptors, Progesterone - metabolism
  • Receptors, Progesterone - physiology
  • Research
  • Signal transduction
  • Tamoxifen - therapeutic use
  • Ubiquitination
ispartof: Nature medicine, 2011-06, Vol.17 (6), p.708-714
description: Endocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we report that CUE domain-containing protein-2 (CUEDC2), a ubiquitin-binding motif-containing protein, is a key factor in endocrine resistance in breast cancer. We show that CUEDC2 modulates ER-α protein stability through the ubiquitin-proteasome pathway. Through the study of specimens from a large cohort of subjects with breast cancer, we found a strong inverse correlation between CUEDC2 and ER-α protein expression. Notably, subjects with tumors that highly expressed CUEDC2 had poor responsiveness to tamoxifen treatment and high potential for relapse. We further show that ectopic CUEDC2 expression impaired the responsiveness of breast cancer cells to tamoxifen. Therefore, our findings suggest that CUEDC2 is a crucial determinant of resistance to endocrine therapies in breast cancer.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6067235
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_871003753
sourceformatXML
sourcesystemPC
galeidA259078222
sourcerecordidA259078222
originalsourceidFETCH-LOGICAL-1492t-4f2a384a25fa4a0dd1b193313a199eff0310dd6e0753df8d730afb5921d37ec00
addsrcrecordideNqNkl1vFCEUhifGxn5o_AeGeGHjxax8DDvDZbNdtUmTJtYa7wjLHFqaGdgCY9p_79l0Nd16Y7gADs97OLycqnrL6IxR0X0K44yLuXpRHTDZzGvW0p8vcU3bru6UnO9XhznfUkoFlepVtc-ZbHnDu4PqcjnAL1OgJ3C_TpCzj4FERxZXy9MFJ-sUC_hAbAwOUiYQ-miTD0CQ9bmYYIHg-SqByYXYzT69rvacGTK82c5H1dXn5ffF1_r84svZ4uS8Zo3ipW4cN6JrDJfONIb2PVsxJQQThikFzlHBMDgH2krRu65vBTVuJRVnvWjBUnpUHT_mxSrvJshFjz5bGAYTIE5Zdy3DF6MayffPyNs4pYDFIUQbKRXrEJo9QtdmAO2DiyUZi6OH0aMB4DzGT7hUaCvnHAUfdwTIFLgv12bKWZ9dfvt_9uLHLvvhCXsDZig3OQ5Twb_Ju-DWAJtizgmcXic_mvSgGdWbvtBh1Ju-QPLd1oBpNUL_l_vTCAjUz1JZX8zmRjTBD_8k_A1rb731
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid870455918
display
typearticle
titleElevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
creatorPan, Xin ; Zhou, Tao ; Tai, Yan-Hong ; Wang, Chenguang ; Zhao, Jie ; Cao, Yuan ; Chen, Yuan ; Zhang, Pei-Jing ; Yu, Ming ; Zhen, Cheng ; Mu, Rui ; Bai, Zhao-Fang ; Li, Hui-Yan ; Li, Ai-Ling ; Liang, Bing ; Jian, Zhao ; Zhang, Wei-Na ; Man, Jiang-Hong ; Gao, Yan-Fei ; Gong, Wei-Li ; Wei, Li-Xin ; Zhang, Xue-Min
creatorcontribPan, Xin ; Zhou, Tao ; Tai, Yan-Hong ; Wang, Chenguang ; Zhao, Jie ; Cao, Yuan ; Chen, Yuan ; Zhang, Pei-Jing ; Yu, Ming ; Zhen, Cheng ; Mu, Rui ; Bai, Zhao-Fang ; Li, Hui-Yan ; Li, Ai-Ling ; Liang, Bing ; Jian, Zhao ; Zhang, Wei-Na ; Man, Jiang-Hong ; Gao, Yan-Fei ; Gong, Wei-Li ; Wei, Li-Xin ; Zhang, Xue-Min
descriptionEndocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we report that CUE domain-containing protein-2 (CUEDC2), a ubiquitin-binding motif-containing protein, is a key factor in endocrine resistance in breast cancer. We show that CUEDC2 modulates ER-α protein stability through the ubiquitin-proteasome pathway. Through the study of specimens from a large cohort of subjects with breast cancer, we found a strong inverse correlation between CUEDC2 and ER-α protein expression. Notably, subjects with tumors that highly expressed CUEDC2 had poor responsiveness to tamoxifen treatment and high potential for relapse. We further show that ectopic CUEDC2 expression impaired the responsiveness of breast cancer cells to tamoxifen. Therefore, our findings suggest that CUEDC2 is a crucial determinant of resistance to endocrine therapies in breast cancer.
identifier
0ISSN: 1078-8956
1EISSN: 1546-170X
2DOI: 10.1038/nm.2369
3PMID: 21572428
languageeng
publisherUnited States: Nature Publishing Group
subjectAntineoplastic Agents, Hormonal - therapeutic use ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - physiopathology ; Care and treatment ; Carrier Proteins - biosynthesis ; Carrier Proteins - physiology ; Cell Line, Tumor ; Down-Regulation ; Drug Resistance, Neoplasm - physiology ; Endocrine therapy ; Estrogen Receptor alpha - metabolism ; Estrogen Receptor alpha - physiology ; Estrogens ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic - physiology ; Genetic aspects ; Health aspects ; Hormone therapy ; Humans ; I-kappa B Kinase - metabolism ; I-kappa B Kinase - physiology ; Membrane Proteins - biosynthesis ; Membrane Proteins - physiology ; Phosphorylation ; Proteins ; Receptors, Progesterone - metabolism ; Receptors, Progesterone - physiology ; Research ; Signal transduction ; Tamoxifen - therapeutic use ; Ubiquitination
ispartofNature medicine, 2011-06, Vol.17 (6), p.708-714
rights
0COPYRIGHT 2011 Nature Publishing Group
1Copyright Nature Publishing Group Jun 2011
lds50peer_reviewed
citedbyFETCH-LOGICAL-1492t-4f2a384a25fa4a0dd1b193313a199eff0310dd6e0753df8d730afb5921d37ec00
citesFETCH-LOGICAL-1492t-4f2a384a25fa4a0dd1b193313a199eff0310dd6e0753df8d730afb5921d37ec00
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21572428$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Pan, Xin
1Zhou, Tao
2Tai, Yan-Hong
3Wang, Chenguang
4Zhao, Jie
5Cao, Yuan
6Chen, Yuan
7Zhang, Pei-Jing
8Yu, Ming
9Zhen, Cheng
10Mu, Rui
11Bai, Zhao-Fang
12Li, Hui-Yan
13Li, Ai-Ling
14Liang, Bing
15Jian, Zhao
16Zhang, Wei-Na
17Man, Jiang-Hong
18Gao, Yan-Fei
19Gong, Wei-Li
20Wei, Li-Xin
21Zhang, Xue-Min
title
0Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
1Nature medicine
addtitleNat Med
descriptionEndocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we report that CUE domain-containing protein-2 (CUEDC2), a ubiquitin-binding motif-containing protein, is a key factor in endocrine resistance in breast cancer. We show that CUEDC2 modulates ER-α protein stability through the ubiquitin-proteasome pathway. Through the study of specimens from a large cohort of subjects with breast cancer, we found a strong inverse correlation between CUEDC2 and ER-α protein expression. Notably, subjects with tumors that highly expressed CUEDC2 had poor responsiveness to tamoxifen treatment and high potential for relapse. We further show that ectopic CUEDC2 expression impaired the responsiveness of breast cancer cells to tamoxifen. Therefore, our findings suggest that CUEDC2 is a crucial determinant of resistance to endocrine therapies in breast cancer.
subject
0Antineoplastic Agents, Hormonal - therapeutic use
1Breast cancer
2Breast Neoplasms - drug therapy
3Breast Neoplasms - physiopathology
4Care and treatment
5Carrier Proteins - biosynthesis
6Carrier Proteins - physiology
7Cell Line, Tumor
8Down-Regulation
9Drug Resistance, Neoplasm - physiology
10Endocrine therapy
11Estrogen Receptor alpha - metabolism
12Estrogen Receptor alpha - physiology
13Estrogens
14Female
15Gene expression
16Gene Expression Regulation, Neoplastic - physiology
17Genetic aspects
18Health aspects
19Hormone therapy
20Humans
21I-kappa B Kinase - metabolism
22I-kappa B Kinase - physiology
23Membrane Proteins - biosynthesis
24Membrane Proteins - physiology
25Phosphorylation
26Proteins
27Receptors, Progesterone - metabolism
28Receptors, Progesterone - physiology
29Research
30Signal transduction
31Tamoxifen - therapeutic use
32Ubiquitination
issn
01078-8956
11546-170X
fulltextfalse
rsrctypearticle
creationdate2011
recordtypearticle
recordideNqNkl1vFCEUhifGxn5o_AeGeGHjxax8DDvDZbNdtUmTJtYa7wjLHFqaGdgCY9p_79l0Nd16Y7gADs97OLycqnrL6IxR0X0K44yLuXpRHTDZzGvW0p8vcU3bru6UnO9XhznfUkoFlepVtc-ZbHnDu4PqcjnAL1OgJ3C_TpCzj4FERxZXy9MFJ-sUC_hAbAwOUiYQ-miTD0CQ9bmYYIHg-SqByYXYzT69rvacGTK82c5H1dXn5ffF1_r84svZ4uS8Zo3ipW4cN6JrDJfONIb2PVsxJQQThikFzlHBMDgH2krRu65vBTVuJRVnvWjBUnpUHT_mxSrvJshFjz5bGAYTIE5Zdy3DF6MayffPyNs4pYDFIUQbKRXrEJo9QtdmAO2DiyUZi6OH0aMB4DzGT7hUaCvnHAUfdwTIFLgv12bKWZ9dfvt_9uLHLvvhCXsDZig3OQ5Twb_Ju-DWAJtizgmcXic_mvSgGdWbvtBh1Ju-QPLd1oBpNUL_l_vTCAjUz1JZX8zmRjTBD_8k_A1rb731
startdate201106
enddate201106
creator
0Pan, Xin
1Zhou, Tao
2Tai, Yan-Hong
3Wang, Chenguang
4Zhao, Jie
5Cao, Yuan
6Chen, Yuan
7Zhang, Pei-Jing
8Yu, Ming
9Zhen, Cheng
10Mu, Rui
11Bai, Zhao-Fang
12Li, Hui-Yan
13Li, Ai-Ling
14Liang, Bing
15Jian, Zhao
16Zhang, Wei-Na
17Man, Jiang-Hong
18Gao, Yan-Fei
19Gong, Wei-Li
20Wei, Li-Xin
21Zhang, Xue-Min
generalNature Publishing Group
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97QG
107QL
117QP
127QR
137T5
147TK
157TM
167TO
177U7
187U9
197X7
207XB
2188A
2288E
2388I
248AO
258FD
268FE
278FH
288FI
298FJ
308FK
318G5
32ABUWG
33AZQEC
34BBNVY
35BENPR
36BHPHI
37C1K
38DWQXO
39FR3
40FYUFA
41GHDGH
42GNUQQ
43GUQSH
44H94
45HCIFZ
46K9.
47LK8
48M0S
49M1P
50M2O
51M2P
52M7N
53M7P
54MBDVC
55P64
56PADUT
57PQEST
58PQQKQ
59PQUKI
60PRINS
61Q9U
62RC3
637X8
sort
creationdate201106
titleElevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
authorPan, Xin ; Zhou, Tao ; Tai, Yan-Hong ; Wang, Chenguang ; Zhao, Jie ; Cao, Yuan ; Chen, Yuan ; Zhang, Pei-Jing ; Yu, Ming ; Zhen, Cheng ; Mu, Rui ; Bai, Zhao-Fang ; Li, Hui-Yan ; Li, Ai-Ling ; Liang, Bing ; Jian, Zhao ; Zhang, Wei-Na ; Man, Jiang-Hong ; Gao, Yan-Fei ; Gong, Wei-Li ; Wei, Li-Xin ; Zhang, Xue-Min
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1492t-4f2a384a25fa4a0dd1b193313a199eff0310dd6e0753df8d730afb5921d37ec00
rsrctypearticles
prefilterarticles
languageeng
creationdate2011
topic
0Antineoplastic Agents, Hormonal - therapeutic use
1Breast cancer
2Breast Neoplasms - drug therapy
3Breast Neoplasms - physiopathology
4Care and treatment
5Carrier Proteins - biosynthesis
6Carrier Proteins - physiology
7Cell Line, Tumor
8Down-Regulation
9Drug Resistance, Neoplasm - physiology
10Endocrine therapy
11Estrogen Receptor alpha - metabolism
12Estrogen Receptor alpha - physiology
13Estrogens
14Female
15Gene expression
16Gene Expression Regulation, Neoplastic - physiology
17Genetic aspects
18Health aspects
19Hormone therapy
20Humans
21I-kappa B Kinase - metabolism
22I-kappa B Kinase - physiology
23Membrane Proteins - biosynthesis
24Membrane Proteins - physiology
25Phosphorylation
26Proteins
27Receptors, Progesterone - metabolism
28Receptors, Progesterone - physiology
29Research
30Signal transduction
31Tamoxifen - therapeutic use
32Ubiquitination
toplevelpeer_reviewed
creatorcontrib
0Pan, Xin
1Zhou, Tao
2Tai, Yan-Hong
3Wang, Chenguang
4Zhao, Jie
5Cao, Yuan
6Chen, Yuan
7Zhang, Pei-Jing
8Yu, Ming
9Zhen, Cheng
10Mu, Rui
11Bai, Zhao-Fang
12Li, Hui-Yan
13Li, Ai-Ling
14Liang, Bing
15Jian, Zhao
16Zhang, Wei-Na
17Man, Jiang-Hong
18Gao, Yan-Fei
19Gong, Wei-Li
20Wei, Li-Xin
21Zhang, Xue-Min
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Animal Behavior Abstracts
9Bacteriology Abstracts (Microbiology B)
10Calcium & Calcified Tissue Abstracts
11Chemoreception Abstracts
12Immunology Abstracts
13Neurosciences Abstracts
14Nucleic Acids Abstracts
15Oncogenes and Growth Factors Abstracts
16Toxicology Abstracts
17Virology and AIDS Abstracts
18Health & Medical Collection
19ProQuest Central (purchase pre-March 2016)
20Biology Database (Alumni Edition)
21Medical Database (Alumni Edition)
22Science Database (Alumni Edition)
23ProQuest Pharma Collection
24Technology Research Database
25ProQuest SciTech Collection
26ProQuest Natural Science Collection
27Hospital Premium Collection
28Hospital Premium Collection (Alumni Edition)
29ProQuest Central (Alumni) (purchase pre-March 2016)
30Research Library (Alumni Edition)
31ProQuest Central (Alumni Edition)
32ProQuest Central Essentials
33Biological Science Collection
34ProQuest Central
35Natural Science Collection
36Environmental Sciences and Pollution Management
37ProQuest Central Korea
38Engineering Research Database
39Health Research Premium Collection
40Health Research Premium Collection (Alumni)
41ProQuest Central Student
42Research Library Prep
43AIDS and Cancer Research Abstracts
44SciTech Premium Collection
45ProQuest Health & Medical Complete (Alumni)
46ProQuest Biological Science Collection
47Health & Medical Collection (Alumni Edition)
48Medical Database
49Research Library
50Science Database
51Algology Mycology and Protozoology Abstracts (Microbiology C)
52Biological Science Database
53Research Library (Corporate)
54Biotechnology and BioEngineering Abstracts
55Research Library China
56ProQuest One Academic Eastern Edition
57ProQuest One Academic
58ProQuest One Academic UKI Edition
59ProQuest Central China
60ProQuest Central Basic
61Genetics Abstracts
62MEDLINE - Academic
jtitleNature medicine
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Pan, Xin
1Zhou, Tao
2Tai, Yan-Hong
3Wang, Chenguang
4Zhao, Jie
5Cao, Yuan
6Chen, Yuan
7Zhang, Pei-Jing
8Yu, Ming
9Zhen, Cheng
10Mu, Rui
11Bai, Zhao-Fang
12Li, Hui-Yan
13Li, Ai-Ling
14Liang, Bing
15Jian, Zhao
16Zhang, Wei-Na
17Man, Jiang-Hong
18Gao, Yan-Fei
19Gong, Wei-Li
20Wei, Li-Xin
21Zhang, Xue-Min
formatjournal
genrearticle
ristypeJOUR
atitleElevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
jtitleNature medicine
addtitleNat Med
date2011-06
risdate2011
volume17
issue6
spage708
epage714
pages708-714
issn1078-8956
eissn1546-170X
abstractEndocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we report that CUE domain-containing protein-2 (CUEDC2), a ubiquitin-binding motif-containing protein, is a key factor in endocrine resistance in breast cancer. We show that CUEDC2 modulates ER-α protein stability through the ubiquitin-proteasome pathway. Through the study of specimens from a large cohort of subjects with breast cancer, we found a strong inverse correlation between CUEDC2 and ER-α protein expression. Notably, subjects with tumors that highly expressed CUEDC2 had poor responsiveness to tamoxifen treatment and high potential for relapse. We further show that ectopic CUEDC2 expression impaired the responsiveness of breast cancer cells to tamoxifen. Therefore, our findings suggest that CUEDC2 is a crucial determinant of resistance to endocrine therapies in breast cancer.
copUnited States
pubNature Publishing Group
pmid21572428
doi10.1038/nm.2369
tpages8