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Cranioplasty With Adipose-Derived Stem Cells and Biomaterial: A Novel Method for Cranial Reconstruction

Abstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS... Full description

Journal Title: Neurosurgery 2011-06-01, Vol.68 (6), p.1535-1540
Main Author: Thesleff, Tuomo
Other Authors: Lehtimäki, Kai , Niskakangas, Tero , Mannerström, Bettina , Miettinen, Susanna , Suuronen, Riitta , Öhman, Juha
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Oxford University Press
ID: ISSN: 0148-396X
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recordid: cdi_proquest_miscellaneous_879106022
title: Cranioplasty With Adipose-Derived Stem Cells and Biomaterial: A Novel Method for Cranial Reconstruction
format: Article
creator:
  • Thesleff, Tuomo
  • Lehtimäki, Kai
  • Niskakangas, Tero
  • Mannerström, Bettina
  • Miettinen, Susanna
  • Suuronen, Riitta
  • Öhman, Juha
subjects:
  • Adipose Tissue - transplantation
  • Aged
  • Biological and medical sciences
  • Calcium Phosphates - therapeutic use
  • Defects
  • Female
  • Humans
  • Male
  • Medical sciences
  • Middle Aged
  • Neurosurgery
  • Reconstructive Surgical Procedures - methods
  • Skull - surgery
  • Stem Cell Transplantation - methods
  • Stem cells
  • Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
  • Tissue Engineering - methods
  • Tomography
  • Transplantation, Autologous
ispartof: Neurosurgery, 2011-06-01, Vol.68 (6), p.1535-1540
description: Abstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.
language: eng
source:
identifier: ISSN: 0148-396X
fulltext: no_fulltext
issn:
  • 0148-396X
  • 1524-4040
url: Link


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creatorThesleff, Tuomo ; Lehtimäki, Kai ; Niskakangas, Tero ; Mannerström, Bettina ; Miettinen, Susanna ; Suuronen, Riitta ; Öhman, Juha
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descriptionAbstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.
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subjectAdipose Tissue - transplantation ; Aged ; Biological and medical sciences ; Calcium Phosphates - therapeutic use ; Defects ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurosurgery ; Reconstructive Surgical Procedures - methods ; Skull - surgery ; Stem Cell Transplantation - methods ; Stem cells ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Engineering - methods ; Tomography ; Transplantation, Autologous
ispartofNeurosurgery, 2011-06-01, Vol.68 (6), p.1535-1540
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descriptionAbstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.
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abstractAbstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.
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pubOxford University Press
pmid21336223
doi10.1227/NEU.0b013e31820ee24e