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Cardiovascular effects of marine omega-3 fatty acids

Summary Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is recommended in guidelines for management of patients after myocardial infarction. However, questions have been raised... Full description

Journal Title: The Lancet (British edition) 2010, Vol.376 (9740), p.540-550
Main Author: Saravanan, Palaniappan, Dr
Other Authors: Davidson, Neil C, MD , Schmidt, Erik B, Prof , Calder, Philip C, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_proquest_miscellaneous_879480351
title: Cardiovascular effects of marine omega-3 fatty acids
format: Article
creator:
  • Saravanan, Palaniappan, Dr
  • Davidson, Neil C, MD
  • Schmidt, Erik B, Prof
  • Calder, Philip C, Prof
subjects:
  • Abridged Index Medicus
  • Animals
  • Arrhythmias, Cardiac - prevention & control
  • Biological and medical sciences
  • Cardiovascular disease
  • Cardiovascular Diseases - drug therapy
  • Cardiovascular Diseases - prevention & control
  • Care and treatment
  • Coronary Artery Disease - prevention & control
  • Death, Sudden, Cardiac - prevention & control
  • Dietary Supplements
  • Diets
  • Fatty acids
  • Fatty Acids, Omega-3 - therapeutic use
  • General aspects
  • guidelines
  • Health aspects
  • Heart attacks
  • Heart diseases
  • Heart Failure
  • Humans
  • Ingestion
  • Internal Medicine
  • Medical sciences
  • Mortality
  • myocardial infarction
  • Omega-3 fatty acids
  • polyunsaturated fatty acids
  • Reviews
  • Risk factors
  • risk reduction
  • Studies
ispartof: The Lancet (British edition), 2010, Vol.376 (9740), p.540-550
description: Summary Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is recommended in guidelines for management of patients after myocardial infarction. However, questions have been raised about their usefulness alongside optimum medical therapies with agents proven to reduce risk of cardiac events in high-risk patients. Additionally, there is some evidence for a possible pro-arrhythmic effect in subsets of cardiac patients. Some uncertainly exists about the optimum dose needed to obtain beneficial effects and the relative merit of dietary intake of omega-3 polyunsaturated fatty acids versus supplements. We review evidence for the effects of omega-3 polyunsaturated fatty acids on various cardiac disorders and the risk factors for cardiac disease. We also assess areas of uncertainty needing further research.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionSummary Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is recommended in guidelines for management of patients after myocardial infarction. However, questions have been raised about their usefulness alongside optimum medical therapies with agents proven to reduce risk of cardiac events in high-risk patients. Additionally, there is some evidence for a possible pro-arrhythmic effect in subsets of cardiac patients. Some uncertainly exists about the optimum dose needed to obtain beneficial effects and the relative merit of dietary intake of omega-3 polyunsaturated fatty acids versus supplements. We review evidence for the effects of omega-3 polyunsaturated fatty acids on various cardiac disorders and the risk factors for cardiac disease. We also assess areas of uncertainty needing further research.
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subjectAbridged Index Medicus ; Animals ; Arrhythmias, Cardiac - prevention & control ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - prevention & control ; Care and treatment ; Coronary Artery Disease - prevention & control ; Death, Sudden, Cardiac - prevention & control ; Dietary Supplements ; Diets ; Fatty acids ; Fatty Acids, Omega-3 - therapeutic use ; General aspects ; guidelines ; Health aspects ; Heart attacks ; Heart diseases ; Heart Failure ; Humans ; Ingestion ; Internal Medicine ; Medical sciences ; Mortality ; myocardial infarction ; Omega-3 fatty acids ; polyunsaturated fatty acids ; Reviews ; Risk factors ; risk reduction ; Studies
ispartofThe Lancet (British edition), 2010, Vol.376 (9740), p.540-550
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descriptionSummary Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is recommended in guidelines for management of patients after myocardial infarction. However, questions have been raised about their usefulness alongside optimum medical therapies with agents proven to reduce risk of cardiac events in high-risk patients. Additionally, there is some evidence for a possible pro-arrhythmic effect in subsets of cardiac patients. Some uncertainly exists about the optimum dose needed to obtain beneficial effects and the relative merit of dietary intake of omega-3 polyunsaturated fatty acids versus supplements. We review evidence for the effects of omega-3 polyunsaturated fatty acids on various cardiac disorders and the risk factors for cardiac disease. We also assess areas of uncertainty needing further research.
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abstractSummary Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is recommended in guidelines for management of patients after myocardial infarction. However, questions have been raised about their usefulness alongside optimum medical therapies with agents proven to reduce risk of cardiac events in high-risk patients. Additionally, there is some evidence for a possible pro-arrhythmic effect in subsets of cardiac patients. Some uncertainly exists about the optimum dose needed to obtain beneficial effects and the relative merit of dietary intake of omega-3 polyunsaturated fatty acids versus supplements. We review evidence for the effects of omega-3 polyunsaturated fatty acids on various cardiac disorders and the risk factors for cardiac disease. We also assess areas of uncertainty needing further research.
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pmid20638121
doi10.1016/S0140-6736(10)60445-X