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Oxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy

Abstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in high concentrations, it can lead to atheroma formation. Over the past several decades, it has become abundantly evident that the oxidized form of LDL-cholesterol (ox-LDL) is more important in the genesis an... Full description

Journal Title: The American journal of the medical sciences 2011, Vol.342 (2), p.135-142
Main Author: Mitra, Sona, MD
Other Authors: Deshmukh, Abhishek, MD , Sachdeva, Rajesh, MD , Lu, Jingjun, MD, PhD , Mehta, Jawahar L., MD, PhD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Elsevier Inc
ID: ISSN: 0002-9629
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recordid: cdi_proquest_miscellaneous_880136316
title: Oxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy
format: Article
creator:
  • Mitra, Sona, MD
  • Deshmukh, Abhishek, MD
  • Sachdeva, Rajesh, MD
  • Lu, Jingjun, MD, PhD
  • Mehta, Jawahar L., MD, PhD
subjects:
  • Abridged Index Medicus
  • Angiotensin II - metabolism
  • Animals
  • Antioxidants - therapeutic use
  • Apoptosis - physiology
  • Atherogenesis
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - drug therapy
  • Atherosclerosis - etiology
  • Atherosclerosis - metabolism
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Endothelium, Vascular - drug effects
  • Endothelium, Vascular - metabolism
  • General aspects
  • Humans
  • Internal Medicine
  • LDL-cholesterol
  • Lipoproteins, LDL - metabolism
  • Medical sciences
  • Mice
  • Oxidation-Reduction - drug effects
  • Oxidative stress
  • Oxidative Stress - drug effects
  • Oxidative Stress - physiology
  • Scavenger Receptors, Class E - metabolism
ispartof: The American journal of the medical sciences, 2011, Vol.342 (2), p.135-142
description: Abstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in high concentrations, it can lead to atheroma formation. Over the past several decades, it has become abundantly evident that the oxidized form of LDL-cholesterol (ox-LDL) is more important in the genesis and progression of atherosclerosis than native unmodified LDL-cholesterol. Ox-LDL leads to endothelial dysfunction, an initial step in the formation of an atheroma. Ox-LDL acts via binding to a number of scavenger receptors (SR), such as SR-A1, SR-A2 and lectin-like oxidized low-density lipoprotein receptor (LOX-1). Ox-LDL can upregulate expression of its own receptor LOX-1 on endothelial cells and activate these cells. In addition, ox-LDL promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. Ox-LDL also leads to the generation of reactive oxygen species that in physiologic concentrations combat invasion of the body by noxious agents, but when in excess, can lead to a state of oxidative stress. There is evidence for the presence of oxidative stress in a host of conditions such as atherosclerosis and aging. In this review, we discuss the role of oxidative stress, ox-LDL and LOX-1 in atherogenesis and the reasons why the traditional approaches to limit oxidant stress have not been successful.
language: eng
source:
identifier: ISSN: 0002-9629
fulltext: no_fulltext
issn:
  • 0002-9629
  • 1538-2990
url: Link


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titleOxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy
creatorMitra, Sona, MD ; Deshmukh, Abhishek, MD ; Sachdeva, Rajesh, MD ; Lu, Jingjun, MD, PhD ; Mehta, Jawahar L., MD, PhD
creatorcontribMitra, Sona, MD ; Deshmukh, Abhishek, MD ; Sachdeva, Rajesh, MD ; Lu, Jingjun, MD, PhD ; Mehta, Jawahar L., MD, PhD
descriptionAbstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in high concentrations, it can lead to atheroma formation. Over the past several decades, it has become abundantly evident that the oxidized form of LDL-cholesterol (ox-LDL) is more important in the genesis and progression of atherosclerosis than native unmodified LDL-cholesterol. Ox-LDL leads to endothelial dysfunction, an initial step in the formation of an atheroma. Ox-LDL acts via binding to a number of scavenger receptors (SR), such as SR-A1, SR-A2 and lectin-like oxidized low-density lipoprotein receptor (LOX-1). Ox-LDL can upregulate expression of its own receptor LOX-1 on endothelial cells and activate these cells. In addition, ox-LDL promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. Ox-LDL also leads to the generation of reactive oxygen species that in physiologic concentrations combat invasion of the body by noxious agents, but when in excess, can lead to a state of oxidative stress. There is evidence for the presence of oxidative stress in a host of conditions such as atherosclerosis and aging. In this review, we discuss the role of oxidative stress, ox-LDL and LOX-1 in atherogenesis and the reasons why the traditional approaches to limit oxidant stress have not been successful.
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subjectAbridged Index Medicus ; Angiotensin II - metabolism ; Animals ; Antioxidants - therapeutic use ; Apoptosis - physiology ; Atherogenesis ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - drug therapy ; Atherosclerosis - etiology ; Atherosclerosis - metabolism ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; General aspects ; Humans ; Internal Medicine ; LDL-cholesterol ; Lipoproteins, LDL - metabolism ; Medical sciences ; Mice ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Scavenger Receptors, Class E - metabolism
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descriptionAbstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in high concentrations, it can lead to atheroma formation. Over the past several decades, it has become abundantly evident that the oxidized form of LDL-cholesterol (ox-LDL) is more important in the genesis and progression of atherosclerosis than native unmodified LDL-cholesterol. Ox-LDL leads to endothelial dysfunction, an initial step in the formation of an atheroma. Ox-LDL acts via binding to a number of scavenger receptors (SR), such as SR-A1, SR-A2 and lectin-like oxidized low-density lipoprotein receptor (LOX-1). Ox-LDL can upregulate expression of its own receptor LOX-1 on endothelial cells and activate these cells. In addition, ox-LDL promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. Ox-LDL also leads to the generation of reactive oxygen species that in physiologic concentrations combat invasion of the body by noxious agents, but when in excess, can lead to a state of oxidative stress. There is evidence for the presence of oxidative stress in a host of conditions such as atherosclerosis and aging. In this review, we discuss the role of oxidative stress, ox-LDL and LOX-1 in atherogenesis and the reasons why the traditional approaches to limit oxidant stress have not been successful.
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1Angiotensin II - metabolism
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3Antioxidants - therapeutic use
4Apoptosis - physiology
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7Atherosclerosis (general aspects, experimental research)
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abstractAbstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in high concentrations, it can lead to atheroma formation. Over the past several decades, it has become abundantly evident that the oxidized form of LDL-cholesterol (ox-LDL) is more important in the genesis and progression of atherosclerosis than native unmodified LDL-cholesterol. Ox-LDL leads to endothelial dysfunction, an initial step in the formation of an atheroma. Ox-LDL acts via binding to a number of scavenger receptors (SR), such as SR-A1, SR-A2 and lectin-like oxidized low-density lipoprotein receptor (LOX-1). Ox-LDL can upregulate expression of its own receptor LOX-1 on endothelial cells and activate these cells. In addition, ox-LDL promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. Ox-LDL also leads to the generation of reactive oxygen species that in physiologic concentrations combat invasion of the body by noxious agents, but when in excess, can lead to a state of oxidative stress. There is evidence for the presence of oxidative stress in a host of conditions such as atherosclerosis and aging. In this review, we discuss the role of oxidative stress, ox-LDL and LOX-1 in atherogenesis and the reasons why the traditional approaches to limit oxidant stress have not been successful.
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pmid21747278
doi10.1097/MAJ.0b013e318224a147