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Data Supporting a New Physiological Role for Brain Apelin in the Regulation of Hypothalamic Oxytocin Neurons in Lactating Rats

Apelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridizatio... Full description

Journal Title: Endocrinology (Philadelphia) 2011, Vol.152 (9), p.3492-3503
Main Author: Bodineau, Laurence
Other Authors: Taveau, Christopher , Lê Quan Sang, Hong-Hanh , Osterstock, Guillaume , Queguiner, Isabelle , Moos, Françoise , Frugière, Alain , Llorens-Cortes, Catherine
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Chevy Chase, MD: Endocrine Society
ID: ISSN: 0013-7227
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recordid: cdi_proquest_miscellaneous_885294906
title: Data Supporting a New Physiological Role for Brain Apelin in the Regulation of Hypothalamic Oxytocin Neurons in Lactating Rats
format: Article
creator:
  • Bodineau, Laurence
  • Taveau, Christopher
  • Lê Quan Sang, Hong-Hanh
  • Osterstock, Guillaume
  • Queguiner, Isabelle
  • Moos, Françoise
  • Frugière, Alain
  • Llorens-Cortes, Catherine
subjects:
  • Abridged Index Medicus
  • Animals
  • Apelin
  • Biological and medical sciences
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Hypothalamus - drug effects
  • Hypothalamus - metabolism
  • Intercellular Signaling Peptides and Proteins - genetics
  • Intercellular Signaling Peptides and Proteins - metabolism
  • Intercellular Signaling Peptides and Proteins - pharmacology
  • Lactation - metabolism
  • Neurons - drug effects
  • Neurons - metabolism
  • Oxytocin - metabolism
  • Rats
  • Rats, Wistar
  • Vertebrates: endocrinology
ispartof: Endocrinology (Philadelphia), 2011, Vol.152 (9), p.3492-3503
description: Apelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridization and immunohistochemistry demonstrated the presence of apelin receptor mRNA in hypothalamic OXY neurons. Double immunofluorescence labeling then revealed the colocalization of apelin with OXY in about 20% of the hypothalamic OXY-positive neurons. Intracerebroventricular apelin administration inhibited the activity of magnocellular and parvocellular OXY neurons, as shown by measuring the c-fos expression in OXY neurons or by direct electrophysiological measurements of the electrical activity of these neurons. This effect was correlated with a decrease in the amount of milk ejected. Thus, apelin inhibits the activity of OXY neurons through a direct action on apelin receptors expressed by these neurons in an autocrine and paracrine manner. In conclusion, these findings highlight the inhibitory role of apelin as an autocrine/paracrine peptide acting on OXY neurons during breastfeeding.
language: eng
source:
identifier: ISSN: 0013-7227
fulltext: no_fulltext
issn:
  • 0013-7227
  • 1945-7170
url: Link


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titleData Supporting a New Physiological Role for Brain Apelin in the Regulation of Hypothalamic Oxytocin Neurons in Lactating Rats
creatorBodineau, Laurence ; Taveau, Christopher ; Lê Quan Sang, Hong-Hanh ; Osterstock, Guillaume ; Queguiner, Isabelle ; Moos, Françoise ; Frugière, Alain ; Llorens-Cortes, Catherine
creatorcontribBodineau, Laurence ; Taveau, Christopher ; Lê Quan Sang, Hong-Hanh ; Osterstock, Guillaume ; Queguiner, Isabelle ; Moos, Françoise ; Frugière, Alain ; Llorens-Cortes, Catherine
descriptionApelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridization and immunohistochemistry demonstrated the presence of apelin receptor mRNA in hypothalamic OXY neurons. Double immunofluorescence labeling then revealed the colocalization of apelin with OXY in about 20% of the hypothalamic OXY-positive neurons. Intracerebroventricular apelin administration inhibited the activity of magnocellular and parvocellular OXY neurons, as shown by measuring the c-fos expression in OXY neurons or by direct electrophysiological measurements of the electrical activity of these neurons. This effect was correlated with a decrease in the amount of milk ejected. Thus, apelin inhibits the activity of OXY neurons through a direct action on apelin receptors expressed by these neurons in an autocrine and paracrine manner. In conclusion, these findings highlight the inhibitory role of apelin as an autocrine/paracrine peptide acting on OXY neurons during breastfeeding.
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subjectAbridged Index Medicus ; Animals ; Apelin ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Intercellular Signaling Peptides and Proteins - genetics ; Intercellular Signaling Peptides and Proteins - metabolism ; Intercellular Signaling Peptides and Proteins - pharmacology ; Lactation - metabolism ; Neurons - drug effects ; Neurons - metabolism ; Oxytocin - metabolism ; Rats ; Rats, Wistar ; Vertebrates: endocrinology
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descriptionApelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridization and immunohistochemistry demonstrated the presence of apelin receptor mRNA in hypothalamic OXY neurons. Double immunofluorescence labeling then revealed the colocalization of apelin with OXY in about 20% of the hypothalamic OXY-positive neurons. Intracerebroventricular apelin administration inhibited the activity of magnocellular and parvocellular OXY neurons, as shown by measuring the c-fos expression in OXY neurons or by direct electrophysiological measurements of the electrical activity of these neurons. This effect was correlated with a decrease in the amount of milk ejected. Thus, apelin inhibits the activity of OXY neurons through a direct action on apelin receptors expressed by these neurons in an autocrine and paracrine manner. In conclusion, these findings highlight the inhibitory role of apelin as an autocrine/paracrine peptide acting on OXY neurons during breastfeeding.
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5Fundamental and applied biological sciences. Psychology
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7Hypothalamus - metabolism
8Intercellular Signaling Peptides and Proteins - genetics
9Intercellular Signaling Peptides and Proteins - metabolism
10Intercellular Signaling Peptides and Proteins - pharmacology
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12Neurons - drug effects
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abstractApelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridization and immunohistochemistry demonstrated the presence of apelin receptor mRNA in hypothalamic OXY neurons. Double immunofluorescence labeling then revealed the colocalization of apelin with OXY in about 20% of the hypothalamic OXY-positive neurons. Intracerebroventricular apelin administration inhibited the activity of magnocellular and parvocellular OXY neurons, as shown by measuring the c-fos expression in OXY neurons or by direct electrophysiological measurements of the electrical activity of these neurons. This effect was correlated with a decrease in the amount of milk ejected. Thus, apelin inhibits the activity of OXY neurons through a direct action on apelin receptors expressed by these neurons in an autocrine and paracrine manner. In conclusion, these findings highlight the inhibitory role of apelin as an autocrine/paracrine peptide acting on OXY neurons during breastfeeding.
copChevy Chase, MD
pubEndocrine Society
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doi10.1210/en.2011-0206
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