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Quality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically

Background: Measurement of quality of life (QOL) allows assessment of the impact of a disease or treatment from the patient's perspective, including need for social, emotional, or physical support. We are not aware of any published QOL assessment in patients with bilateral primary aldosteronism (BPA... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2011-09, Vol.96 (9), p.2904-2911
Main Author: Ahmed, Ashraf H
Other Authors: Gordon, Richard D , Sukor, Norlela , Pimenta, Eduardo , Stowasser, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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recordid: cdi_proquest_miscellaneous_888091448
title: Quality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically
format: Article
creator:
  • Ahmed, Ashraf H
  • Gordon, Richard D
  • Sukor, Norlela
  • Pimenta, Eduardo
  • Stowasser, Michael
subjects:
  • Abridged Index Medicus
  • Adrenalectomy
  • Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
  • Adult
  • Aged
  • Aldosterone - blood
  • Amiloride - therapeutic use
  • Australia
  • Biological and medical sciences
  • Diuretics - therapeutic use
  • Drug Therapy, Combination
  • Endocrinopathies
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Hyperaldosteronism - drug therapy
  • Hyperaldosteronism - psychology
  • Hyperaldosteronism - surgery
  • Male
  • Medical sciences
  • Mental Health
  • Middle Aged
  • Mineralocorticoid Receptor Antagonists - therapeutic use
  • Non tumoral diseases. Target tissue resistance. Benign neoplasms
  • Quality of Life
  • Renin - blood
  • Social Support
  • Spironolactone - therapeutic use
  • Surveys and Questionnaires
  • Treatment Outcome
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2011-09, Vol.96 (9), p.2904-2911
description: Background: Measurement of quality of life (QOL) allows assessment of the impact of a disease or treatment from the patient's perspective, including need for social, emotional, or physical support. We are not aware of any published QOL assessment in patients with bilateral primary aldosteronism (BPA), before or after commencing medical treatment (MT) with spironolactone and/or amiloride. Methods: Using the internationally validated Medical Outcomes Study Short Form 36 General Health Survey (SF-36), QOL was assessed in 21 patients with BPA at baseline (time of diagnosis), and at 3 and 6 months after commencing MT. QOL scores at baseline were compared with published normative values for the Australian population. The results of the current study were compared with those from our previous study showing reduced QOL in patients with unilateral primary aldosteronism (UPA) with normalization by 3 months after unilateral laparoscopic adrenalectomy. Results: Compared with the general population, patients with BPA showed significant reduction (P < 0.01) in four QOL domains—physical functioning, role limitations due to physical health problems, general health perceptions, and vitality. After 6 months (but not 3 months) of MT, statistically significant (P < 0.05) improvements were detected in all these domains of QOL. When compared with patients with UPA treated surgically, scores were significantly (P < 0.05) lower at 3 months for five domains (role limitations due to physical health, general health, role limitations due to emotional health, mental health, and vitality) but at 6 months for only one domain (role limitations due to emotional problems). Conclusion: Subnormal QOL scores were improved after 6 months of MT in 21 patients with BPA, but more slowly and to a lesser degree than surgical treatment had previously been shown to improve QOL scores in 22 patients with UPA.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleQuality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically
creatorAhmed, Ashraf H ; Gordon, Richard D ; Sukor, Norlela ; Pimenta, Eduardo ; Stowasser, Michael
creatorcontribAhmed, Ashraf H ; Gordon, Richard D ; Sukor, Norlela ; Pimenta, Eduardo ; Stowasser, Michael
descriptionBackground: Measurement of quality of life (QOL) allows assessment of the impact of a disease or treatment from the patient's perspective, including need for social, emotional, or physical support. We are not aware of any published QOL assessment in patients with bilateral primary aldosteronism (BPA), before or after commencing medical treatment (MT) with spironolactone and/or amiloride. Methods: Using the internationally validated Medical Outcomes Study Short Form 36 General Health Survey (SF-36), QOL was assessed in 21 patients with BPA at baseline (time of diagnosis), and at 3 and 6 months after commencing MT. QOL scores at baseline were compared with published normative values for the Australian population. The results of the current study were compared with those from our previous study showing reduced QOL in patients with unilateral primary aldosteronism (UPA) with normalization by 3 months after unilateral laparoscopic adrenalectomy. Results: Compared with the general population, patients with BPA showed significant reduction (P < 0.01) in four QOL domains—physical functioning, role limitations due to physical health problems, general health perceptions, and vitality. After 6 months (but not 3 months) of MT, statistically significant (P < 0.05) improvements were detected in all these domains of QOL. When compared with patients with UPA treated surgically, scores were significantly (P < 0.05) lower at 3 months for five domains (role limitations due to physical health, general health, role limitations due to emotional health, mental health, and vitality) but at 6 months for only one domain (role limitations due to emotional problems). Conclusion: Subnormal QOL scores were improved after 6 months of MT in 21 patients with BPA, but more slowly and to a lesser degree than surgical treatment had previously been shown to improve QOL scores in 22 patients with UPA.
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subjectAbridged Index Medicus ; Adrenalectomy ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Aged ; Aldosterone - blood ; Amiloride - therapeutic use ; Australia ; Biological and medical sciences ; Diuretics - therapeutic use ; Drug Therapy, Combination ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperaldosteronism - drug therapy ; Hyperaldosteronism - psychology ; Hyperaldosteronism - surgery ; Male ; Medical sciences ; Mental Health ; Middle Aged ; Mineralocorticoid Receptor Antagonists - therapeutic use ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Quality of Life ; Renin - blood ; Social Support ; Spironolactone - therapeutic use ; Surveys and Questionnaires ; Treatment Outcome ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology
ispartofThe journal of clinical endocrinology and metabolism, 2011-09, Vol.96 (9), p.2904-2911
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0Ahmed, Ashraf H
1Gordon, Richard D
2Sukor, Norlela
3Pimenta, Eduardo
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0Quality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionBackground: Measurement of quality of life (QOL) allows assessment of the impact of a disease or treatment from the patient's perspective, including need for social, emotional, or physical support. We are not aware of any published QOL assessment in patients with bilateral primary aldosteronism (BPA), before or after commencing medical treatment (MT) with spironolactone and/or amiloride. Methods: Using the internationally validated Medical Outcomes Study Short Form 36 General Health Survey (SF-36), QOL was assessed in 21 patients with BPA at baseline (time of diagnosis), and at 3 and 6 months after commencing MT. QOL scores at baseline were compared with published normative values for the Australian population. The results of the current study were compared with those from our previous study showing reduced QOL in patients with unilateral primary aldosteronism (UPA) with normalization by 3 months after unilateral laparoscopic adrenalectomy. Results: Compared with the general population, patients with BPA showed significant reduction (P < 0.01) in four QOL domains—physical functioning, role limitations due to physical health problems, general health perceptions, and vitality. After 6 months (but not 3 months) of MT, statistically significant (P < 0.05) improvements were detected in all these domains of QOL. When compared with patients with UPA treated surgically, scores were significantly (P < 0.05) lower at 3 months for five domains (role limitations due to physical health, general health, role limitations due to emotional health, mental health, and vitality) but at 6 months for only one domain (role limitations due to emotional problems). Conclusion: Subnormal QOL scores were improved after 6 months of MT in 21 patients with BPA, but more slowly and to a lesser degree than surgical treatment had previously been shown to improve QOL scores in 22 patients with UPA.
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0Abridged Index Medicus
1Adrenalectomy
2Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
3Adult
4Aged
5Aldosterone - blood
6Amiloride - therapeutic use
7Australia
8Biological and medical sciences
9Diuretics - therapeutic use
10Drug Therapy, Combination
11Endocrinopathies
12Feeding. Feeding behavior
13Female
14Fundamental and applied biological sciences. Psychology
15Humans
16Hyperaldosteronism - drug therapy
17Hyperaldosteronism - psychology
18Hyperaldosteronism - surgery
19Male
20Medical sciences
21Mental Health
22Middle Aged
23Mineralocorticoid Receptor Antagonists - therapeutic use
24Non tumoral diseases. Target tissue resistance. Benign neoplasms
25Quality of Life
26Renin - blood
27Social Support
28Spironolactone - therapeutic use
29Surveys and Questionnaires
30Treatment Outcome
31Vertebrates: anatomy and physiology, studies on body, several organs or systems
32Vertebrates: endocrinology
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titleQuality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically
authorAhmed, Ashraf H ; Gordon, Richard D ; Sukor, Norlela ; Pimenta, Eduardo ; Stowasser, Michael
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0Abridged Index Medicus
1Adrenalectomy
2Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
3Adult
4Aged
5Aldosterone - blood
6Amiloride - therapeutic use
7Australia
8Biological and medical sciences
9Diuretics - therapeutic use
10Drug Therapy, Combination
11Endocrinopathies
12Feeding. Feeding behavior
13Female
14Fundamental and applied biological sciences. Psychology
15Humans
16Hyperaldosteronism - drug therapy
17Hyperaldosteronism - psychology
18Hyperaldosteronism - surgery
19Male
20Medical sciences
21Mental Health
22Middle Aged
23Mineralocorticoid Receptor Antagonists - therapeutic use
24Non tumoral diseases. Target tissue resistance. Benign neoplasms
25Quality of Life
26Renin - blood
27Social Support
28Spironolactone - therapeutic use
29Surveys and Questionnaires
30Treatment Outcome
31Vertebrates: anatomy and physiology, studies on body, several organs or systems
32Vertebrates: endocrinology
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4Stowasser, Michael
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atitleQuality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically
jtitleThe journal of clinical endocrinology and metabolism
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issue9
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abstractBackground: Measurement of quality of life (QOL) allows assessment of the impact of a disease or treatment from the patient's perspective, including need for social, emotional, or physical support. We are not aware of any published QOL assessment in patients with bilateral primary aldosteronism (BPA), before or after commencing medical treatment (MT) with spironolactone and/or amiloride. Methods: Using the internationally validated Medical Outcomes Study Short Form 36 General Health Survey (SF-36), QOL was assessed in 21 patients with BPA at baseline (time of diagnosis), and at 3 and 6 months after commencing MT. QOL scores at baseline were compared with published normative values for the Australian population. The results of the current study were compared with those from our previous study showing reduced QOL in patients with unilateral primary aldosteronism (UPA) with normalization by 3 months after unilateral laparoscopic adrenalectomy. Results: Compared with the general population, patients with BPA showed significant reduction (P < 0.01) in four QOL domains—physical functioning, role limitations due to physical health problems, general health perceptions, and vitality. After 6 months (but not 3 months) of MT, statistically significant (P < 0.05) improvements were detected in all these domains of QOL. When compared with patients with UPA treated surgically, scores were significantly (P < 0.05) lower at 3 months for five domains (role limitations due to physical health, general health, role limitations due to emotional health, mental health, and vitality) but at 6 months for only one domain (role limitations due to emotional problems). Conclusion: Subnormal QOL scores were improved after 6 months of MT in 21 patients with BPA, but more slowly and to a lesser degree than surgical treatment had previously been shown to improve QOL scores in 22 patients with UPA.
copBethesda, MD
pubEndocrine Society
pmid21778218
doi10.1210/jc.2011-0138
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