Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies
Journal Title: | The Lancet (British edition) 2011, Vol.378 (9799), p.1297-1305 |
Main Author: | Huxley, Rachel R, Dr |
Other Authors: | Woodward, Mark, PhD |
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English |
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Quelle: | Alma/SFX Local Collection |
Publisher: | Kidlington: Elsevier Ltd |
ID: | ISSN: 0140-6736 |
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recordid: | cdi_proquest_miscellaneous_897812621 |
title: | Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies |
format: | Article |
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ispartof: | The Lancet (British edition), 2011, Vol.378 (9799), p.1297-1305 |
description: | Summary Background Prevalence of smoking is increasing in women in some populations and is a risk factor for coronary heart disease. Whether smoking confers the same excess risk of coronary heart disease for women as it does for men is unknown. Therefore, we aimed to estimate the effect of smoking on coronary heart disease in women compared with men after accounting for sex differences in other major risk factors. Methods We undertook a systematic review and meta-analysis of prospective cohort studies published between Jan 1, 1966, and Dec 31, 2010, from four online databases. We selected cohort studies that were stratified by sex with measures of relative risk (RR), and associated variability, for coronary heart disease and current smoking compared with not smoking. We pooled data with a random effects model with inverse variance weighting, and estimated RR ratios (RRRs) between men and women. Findings We reviewed 8005 abstracts and included 26 articles with data for 3 912 809 individuals and 67 075 coronary heart disease events from 86 prospective trials. In 75 cohorts (2·4 million participants) that adjusted for cardiovascular risk factors other than coronary heart disease, the pooled adjusted female-to-male RRR of smoking compared with not smoking for coronary heart disease was 1·25 (95% CI 1·12–1·39, p |
language: | eng |
source: | Alma/SFX Local Collection |
identifier: | ISSN: 0140-6736 |
fulltext: | fulltext |
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