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Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results

The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian can... Full description

Journal Title: Nature medicine 2011, Vol.17 (10), p.1315-U202
Main Author: van Dam, Gooitzen M
Other Authors: Themelis, George , Crane, Lucia M. A , Harlaar, Niels J , Pleijhuis, Rick G , Kelder, Wendy , Sarantopoulos, Athanasios , de Jong, Johannes S , Arts, Henriette J. G , van der Zee, Ate G. J , Bart, Joost , Low, Philip S , Ntziachristos, Vasilis
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/21926976
Zum Text:
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title: Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results
format: Article
creator:
  • van Dam, Gooitzen M
  • Themelis, George
  • Crane, Lucia M. A
  • Harlaar, Niels J
  • Pleijhuis, Rick G
  • Kelder, Wendy
  • Sarantopoulos, Athanasios
  • de Jong, Johannes S
  • Arts, Henriette J. G
  • van der Zee, Ate G. J
  • Bart, Joost
  • Low, Philip S
  • Ntziachristos, Vasilis
subjects:
  • Aged
  • BREAST-CANCER
  • Diagnostic Imaging - methods
  • EXPRESSION
  • Female
  • Fluorescein-5-isothiocyanate - chemistry
  • Folate Receptor 1 - metabolism
  • FUTURE
  • Humans
  • MANAGEMENT
  • Microscopy, Fluorescence - methods
  • Middle Aged
  • Molecular Structure
  • Monitoring, Intraoperative - methods
  • Ovarian Neoplasms - pathology
  • STRATEGIES
  • SURGERY
  • SURVIVAL
  • TISSUE
ispartof: Nature medicine, 2011, Vol.17 (10), p.1315-U202
description: The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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titleIntraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results
creatorvan Dam, Gooitzen M ; Themelis, George ; Crane, Lucia M. A ; Harlaar, Niels J ; Pleijhuis, Rick G ; Kelder, Wendy ; Sarantopoulos, Athanasios ; de Jong, Johannes S ; Arts, Henriette J. G ; van der Zee, Ate G. J ; Bart, Joost ; Low, Philip S ; Ntziachristos, Vasilis
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descriptionThe prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
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descriptionThe prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
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abstractThe prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
copUnited States
pmid21926976
doi10.1038/nm.2472