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Dose–response evaluation of a novel essential oil against Mutans streptococci in vivo

Research has demonstrated the need for identifying a novel antimicrobial agent for topical use in the pediatric dental population. The essential oil of Lippia sidoides Cham. (LSO) has been described as having favorable biological properties, and a broad in vitro and in vivo antimicrobial spectrum ag... Full description

Journal Title: Phytomedicine 2011, Vol.18 (7), p.551-556
Main Author: Lobo, Patrícia Leal Dantas
Other Authors: Fonteles, Cristiane Sá Roriz , de Carvalho, Cibele Barreto Mano , do Nascimento, Demétrius Fernandes , da Cruz Fonseca, Said Gonçalves , Jamacaru, Francisco Vagnaldo Fechine , de Moraes, Maria Elisabete Amaral
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/21112195
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title: Dose–response evaluation of a novel essential oil against Mutans streptococci in vivo
format: Article
creator:
  • Lobo, Patrícia Leal Dantas
  • Fonteles, Cristiane Sá Roriz
  • de Carvalho, Cibele Barreto Mano
  • do Nascimento, Demétrius Fernandes
  • da Cruz Fonseca, Said Gonçalves
  • Jamacaru, Francisco Vagnaldo Fechine
  • de Moraes, Maria Elisabete Amaral
subjects:
  • Administration, Topical
  • alternative medicine
  • Anti-infective agents
  • Anti-Infective Agents, Local - administration & dosage
  • Anti-Infective Agents, Local - pharmacology
  • Anti-Infective Agents, Local - therapeutic use
  • Antimicrobial treatment
  • Brazil
  • Child
  • Colony Count, Microbial
  • Complementary
  • Dental caries
  • Dental Caries - drug therapy
  • Dental Caries - microbiology
  • Dental Plaque - drug therapy
  • Dental Plaque - microbiology
  • Dose-Response Relationship, Drug
  • Drug Discovery
  • Essences and essential oils
  • Female
  • Gels
  • Health aspects
  • Humans
  • Lippia
  • Lippia - chemistry
  • Lippia sidoides Cham
  • Male
  • Molecular Medicine
  • Mouthwashes - administration & dosage
  • Mouthwashes - pharmacology
  • Mouthwashes - therapeutic use
  • Mutans streptococci
  • Oils, Volatile - administration & dosage
  • Oils, Volatile - pharmacology
  • Oils, Volatile - therapeutic use
  • Pharmaceutical Science
  • Pharmacology
  • Physiological aspects
  • Plant Extracts - chemistry
  • Plant Oils - administration & dosage
  • Plant Oils - pharmacology
  • Plant Oils - therapeutic use
  • Saliva - drug effects
  • Saliva - microbiology
  • Streptococcus
  • Streptococcus mutans - drug effects
  • Treatment Outcome
  • Verbena
ispartof: Phytomedicine, 2011, Vol.18 (7), p.551-556
description: Research has demonstrated the need for identifying a novel antimicrobial agent for topical use in the pediatric dental population. The essential oil of Lippia sidoides Cham. (LSO) has been described as having favorable biological properties, and a broad in vitro and in vivo antimicrobial spectrum against bacteria and yeast infections. Our aim was to determine a dose and formulation of LSO, acceptable for clinical testing in a pediatric population with dental caries. Thirty-seven 6–12-year old children were selected to participate in this study, and randomly allocated to receive different concentrations of either a gel (0.8%, 1%, 1.2% and 1.4%) or a mouth rinse (0.6%, 0.8%, 1% and 1.2%) formulation. The highest percentage MS reduction was observed with 0.8% mouth rinse and 1.4% gel. The efficacy of these concentrations was compared with a Thy–Car mixture formulated as a mouth rinse and gel treatments in 11 children. Saliva was collected after a single application of the antimicrobial treatment to establish effectiveness against MS. Both rinse (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleDose–response evaluation of a novel essential oil against Mutans streptococci in vivo
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creatorLobo, Patrícia Leal Dantas ; Fonteles, Cristiane Sá Roriz ; de Carvalho, Cibele Barreto Mano ; do Nascimento, Demétrius Fernandes ; da Cruz Fonseca, Said Gonçalves ; Jamacaru, Francisco Vagnaldo Fechine ; de Moraes, Maria Elisabete Amaral
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descriptionResearch has demonstrated the need for identifying a novel antimicrobial agent for topical use in the pediatric dental population. The essential oil of Lippia sidoides Cham. (LSO) has been described as having favorable biological properties, and a broad in vitro and in vivo antimicrobial spectrum against bacteria and yeast infections. Our aim was to determine a dose and formulation of LSO, acceptable for clinical testing in a pediatric population with dental caries. Thirty-seven 6–12-year old children were selected to participate in this study, and randomly allocated to receive different concentrations of either a gel (0.8%, 1%, 1.2% and 1.4%) or a mouth rinse (0.6%, 0.8%, 1% and 1.2%) formulation. The highest percentage MS reduction was observed with 0.8% mouth rinse and 1.4% gel. The efficacy of these concentrations was compared with a Thy–Car mixture formulated as a mouth rinse and gel treatments in 11 children. Saliva was collected after a single application of the antimicrobial treatment to establish effectiveness against MS. Both rinse (p<0.001) and gel (p=0.02) formulations produced significant MS reduction. Mouth rinse concentrations above 0.8% were associated with a transient intra-oral burning sensation. In conclusion, mouth rinse and gel LSO formulations demonstrated effectiveness against MS and good acceptance among children. We suggest future randomized clinical trials to test its effectiveness against early childhood caries.
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languageeng
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subjectAdministration, Topical ; alternative medicine ; Anti-infective agents ; Anti-Infective Agents, Local - administration & dosage ; Anti-Infective Agents, Local - pharmacology ; Anti-Infective Agents, Local - therapeutic use ; Antimicrobial treatment ; Brazil ; Child ; Colony Count, Microbial ; Complementary ; Dental caries ; Dental Caries - drug therapy ; Dental Caries - microbiology ; Dental Plaque - drug therapy ; Dental Plaque - microbiology ; Dose-Response Relationship, Drug ; Drug Discovery ; Essences and essential oils ; Female ; Gels ; Health aspects ; Humans ; Lippia ; Lippia - chemistry ; Lippia sidoides Cham ; Male ; Molecular Medicine ; Mouthwashes - administration & dosage ; Mouthwashes - pharmacology ; Mouthwashes - therapeutic use ; Mutans streptococci ; Oils, Volatile - administration & dosage ; Oils, Volatile - pharmacology ; Oils, Volatile - therapeutic use ; Pharmaceutical Science ; Pharmacology ; Physiological aspects ; Plant Extracts - chemistry ; Plant Oils - administration & dosage ; Plant Oils - pharmacology ; Plant Oils - therapeutic use ; Saliva - drug effects ; Saliva - microbiology ; Streptococcus ; Streptococcus mutans - drug effects ; Treatment Outcome ; Verbena
ispartofPhytomedicine, 2011, Vol.18 (7), p.551-556
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0Lobo, Patrícia Leal Dantas
1Fonteles, Cristiane Sá Roriz
2de Carvalho, Cibele Barreto Mano
3do Nascimento, Demétrius Fernandes
4da Cruz Fonseca, Said Gonçalves
5Jamacaru, Francisco Vagnaldo Fechine
6de Moraes, Maria Elisabete Amaral
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descriptionResearch has demonstrated the need for identifying a novel antimicrobial agent for topical use in the pediatric dental population. The essential oil of Lippia sidoides Cham. (LSO) has been described as having favorable biological properties, and a broad in vitro and in vivo antimicrobial spectrum against bacteria and yeast infections. Our aim was to determine a dose and formulation of LSO, acceptable for clinical testing in a pediatric population with dental caries. Thirty-seven 6–12-year old children were selected to participate in this study, and randomly allocated to receive different concentrations of either a gel (0.8%, 1%, 1.2% and 1.4%) or a mouth rinse (0.6%, 0.8%, 1% and 1.2%) formulation. The highest percentage MS reduction was observed with 0.8% mouth rinse and 1.4% gel. The efficacy of these concentrations was compared with a Thy–Car mixture formulated as a mouth rinse and gel treatments in 11 children. Saliva was collected after a single application of the antimicrobial treatment to establish effectiveness against MS. Both rinse (p<0.001) and gel (p=0.02) formulations produced significant MS reduction. Mouth rinse concentrations above 0.8% were associated with a transient intra-oral burning sensation. In conclusion, mouth rinse and gel LSO formulations demonstrated effectiveness against MS and good acceptance among children. We suggest future randomized clinical trials to test its effectiveness against early childhood caries.
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1alternative medicine
2Anti-infective agents
3Anti-Infective Agents, Local - administration & dosage
4Anti-Infective Agents, Local - pharmacology
5Anti-Infective Agents, Local - therapeutic use
6Antimicrobial treatment
7Brazil
8Child
9Colony Count, Microbial
10Complementary
11Dental caries
12Dental Caries - drug therapy
13Dental Caries - microbiology
14Dental Plaque - drug therapy
15Dental Plaque - microbiology
16Dose-Response Relationship, Drug
17Drug Discovery
18Essences and essential oils
19Female
20Gels
21Health aspects
22Humans
23Lippia
24Lippia - chemistry
25Lippia sidoides Cham
26Male
27Molecular Medicine
28Mouthwashes - administration & dosage
29Mouthwashes - pharmacology
30Mouthwashes - therapeutic use
31Mutans streptococci
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33Oils, Volatile - pharmacology
34Oils, Volatile - therapeutic use
35Pharmaceutical Science
36Pharmacology
37Physiological aspects
38Plant Extracts - chemistry
39Plant Oils - administration & dosage
40Plant Oils - pharmacology
41Plant Oils - therapeutic use
42Saliva - drug effects
43Saliva - microbiology
44Streptococcus
45Streptococcus mutans - drug effects
46Treatment Outcome
47Verbena
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titleDose–response evaluation of a novel essential oil against Mutans streptococci in vivo
authorLobo, Patrícia Leal Dantas ; Fonteles, Cristiane Sá Roriz ; de Carvalho, Cibele Barreto Mano ; do Nascimento, Demétrius Fernandes ; da Cruz Fonseca, Said Gonçalves ; Jamacaru, Francisco Vagnaldo Fechine ; de Moraes, Maria Elisabete Amaral
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35Pharmaceutical Science
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37Physiological aspects
38Plant Extracts - chemistry
39Plant Oils - administration & dosage
40Plant Oils - pharmacology
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44Streptococcus
45Streptococcus mutans - drug effects
46Treatment Outcome
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atitleDose–response evaluation of a novel essential oil against Mutans streptococci in vivo
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volume18
issue7
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pages551-556
issn0944-7113
eissn1618-095X
abstractResearch has demonstrated the need for identifying a novel antimicrobial agent for topical use in the pediatric dental population. The essential oil of Lippia sidoides Cham. (LSO) has been described as having favorable biological properties, and a broad in vitro and in vivo antimicrobial spectrum against bacteria and yeast infections. Our aim was to determine a dose and formulation of LSO, acceptable for clinical testing in a pediatric population with dental caries. Thirty-seven 6–12-year old children were selected to participate in this study, and randomly allocated to receive different concentrations of either a gel (0.8%, 1%, 1.2% and 1.4%) or a mouth rinse (0.6%, 0.8%, 1% and 1.2%) formulation. The highest percentage MS reduction was observed with 0.8% mouth rinse and 1.4% gel. The efficacy of these concentrations was compared with a Thy–Car mixture formulated as a mouth rinse and gel treatments in 11 children. Saliva was collected after a single application of the antimicrobial treatment to establish effectiveness against MS. Both rinse (p<0.001) and gel (p=0.02) formulations produced significant MS reduction. Mouth rinse concentrations above 0.8% were associated with a transient intra-oral burning sensation. In conclusion, mouth rinse and gel LSO formulations demonstrated effectiveness against MS and good acceptance among children. We suggest future randomized clinical trials to test its effectiveness against early childhood caries.
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pmid21112195
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