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Comparative study of the plasma globulin level, CD21 − B-cell counts and FOXP3 mRNA expression level in CD4 + T-cells for different clinical stages of feline immunodeficiency virus infected cats

Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the... Full description

Journal Title: Research in veterinary science 2012, Vol.92 (1), p.157-161
Main Author: Takano, Tomomi
Other Authors: Hosoya, Shinobu , Shibao, Akari , Nagasaki, Bunpei , Yoshioka, Hisao , Satoh, Ryoichi , Hohdatsu, Tsutomu
Format: Electronic Article Electronic Article
Language: English
Subjects:
FIV
HIV
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier India Pvt Ltd
ID: ISSN: 0034-5288
Link: https://www.ncbi.nlm.nih.gov/pubmed/21074227
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title: Comparative study of the plasma globulin level, CD21 − B-cell counts and FOXP3 mRNA expression level in CD4 + T-cells for different clinical stages of feline immunodeficiency virus infected cats
format: Article
creator:
  • Takano, Tomomi
  • Hosoya, Shinobu
  • Shibao, Akari
  • Nagasaki, Bunpei
  • Yoshioka, Hisao
  • Satoh, Ryoichi
  • Hohdatsu, Tsutomu
subjects:
  • Animals
  • B-Lymphocytes - metabolism
  • Case-Control Studies
  • Cat Diseases - immunology
  • Cat Diseases - virology
  • Cats
  • CD21 − B-cell
  • CD4-Positive T-Lymphocytes - metabolism
  • Disease Progression
  • Feline Acquired Immunodeficiency Syndrome - immunology
  • FIV
  • Forkhead Transcription Factors - metabolism
  • HIV
  • Human immunodeficiency virus
  • Hypergammaglobulinemia
  • Hypergammaglobulinemia - immunology
  • Hypergammaglobulinemia - veterinary
  • Hypergammaglobulinemia - virology
  • Immunodeficiency Virus, Feline - immunology
  • Lentivirus Infections - immunology
  • Lentivirus Infections - veterinary
  • Lymphocyte Count - veterinary
  • Plasma
  • Proteins
  • Receptors, Complement 3d - metabolism
  • Regulatory T-cell
  • RNA, Messenger - analysis
  • Serum Globulins - metabolism
  • T-Lymphocytes, Regulatory - metabolism
  • Viral infections
ispartof: Research in veterinary science, 2012, Vol.92 (1), p.157-161
description: Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4 + T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg) + CD21 − B-cell counts were increased, whereas the CD4 + T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4 + T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0034-5288
fulltext: fulltext
issn:
  • 0034-5288
  • 1532-2661
url: Link


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titleComparative study of the plasma globulin level, CD21 − B-cell counts and FOXP3 mRNA expression level in CD4 + T-cells for different clinical stages of feline immunodeficiency virus infected cats
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creatorTakano, Tomomi ; Hosoya, Shinobu ; Shibao, Akari ; Nagasaki, Bunpei ; Yoshioka, Hisao ; Satoh, Ryoichi ; Hohdatsu, Tsutomu
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descriptionFeline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4 + T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg) + CD21 − B-cell counts were increased, whereas the CD4 + T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4 + T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia.
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languageeng
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subjectAnimals ; B-Lymphocytes - metabolism ; Case-Control Studies ; Cat Diseases - immunology ; Cat Diseases - virology ; Cats ; CD21 − B-cell ; CD4-Positive T-Lymphocytes - metabolism ; Disease Progression ; Feline Acquired Immunodeficiency Syndrome - immunology ; FIV ; Forkhead Transcription Factors - metabolism ; HIV ; Human immunodeficiency virus ; Hypergammaglobulinemia ; Hypergammaglobulinemia - immunology ; Hypergammaglobulinemia - veterinary ; Hypergammaglobulinemia - virology ; Immunodeficiency Virus, Feline - immunology ; Lentivirus Infections - immunology ; Lentivirus Infections - veterinary ; Lymphocyte Count - veterinary ; Plasma ; Proteins ; Receptors, Complement 3d - metabolism ; Regulatory T-cell ; RNA, Messenger - analysis ; Serum Globulins - metabolism ; T-Lymphocytes, Regulatory - metabolism ; Viral infections
ispartofResearch in veterinary science, 2012, Vol.92 (1), p.157-161
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descriptionFeline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4 + T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg) + CD21 − B-cell counts were increased, whereas the CD4 + T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4 + T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia.
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titleComparative study of the plasma globulin level, CD21 − B-cell counts and FOXP3 mRNA expression level in CD4 + T-cells for different clinical stages of feline immunodeficiency virus infected cats
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abstractFeline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4 + T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg) + CD21 − B-cell counts were increased, whereas the CD4 + T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4 + T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia.
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pubElsevier India Pvt Ltd
pmid21074227
doi10.1016/j.rvsc.2010.10.022