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Serum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study

ObjectiveTo explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD).DesignA cross-sectional observational study.SettingSingle centre.Patients208 patients with stage 2 to stage 4 non-diabetic CKD.In... Full description

Journal Title: Heart (British Cardiac Society) 2012, Vol.98 (3), p.219-224
Main Author: Chue, Colin D
Other Authors: Edwards, Nicola C , Moody, William E , Steeds, Richard P , Townend, Jonathan N , Ferro, Charles J
Format: Electronic Article Electronic Article
Language: English
Subjects:
EBM
MRI
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
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title: Serum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study
format: Article
creator:
  • Chue, Colin D
  • Edwards, Nicola C
  • Moody, William E
  • Steeds, Richard P
  • Townend, Jonathan N
  • Ferro, Charles J
subjects:
  • acute coronary syndrome
  • acute myocardial infarction
  • aortic disease
  • Aortic stiffness
  • aortic valve disease
  • Arterial occlusions
  • arterial wall morphology
  • atrial fibrillation
  • autonomic regulation
  • Biological and medical sciences
  • Biomarkers - blood
  • Blood pressure
  • cardiac MRI
  • Cardiology. Vascular system
  • cardiomyopathy
  • Cardiovascular disease
  • cardiovascular risk
  • Care and treatment
  • Chronic kidney failure
  • Cross-Sectional Studies
  • depression
  • Diagnosis
  • Disease Progression
  • EBM
  • echocardiography
  • echocardiography (transoesophageal)
  • endothelium
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • haemodynamics
  • Heart attacks
  • heart failure
  • Heart Ventricles - pathology
  • Heart Ventricles - physiopathology
  • Humans
  • Hypertrophy, Left Ventricular - blood
  • Hypertrophy, Left Ventricular - diagnosis
  • Hypertrophy, Left Ventricular - etiology
  • imaging and diagnostics
  • Kidney Failure, Chronic - blood
  • Kidney Failure, Chronic - complications
  • Kidney Failure, Chronic - physiopathology
  • Kidneys
  • left ventricular mass
  • Magnetic Resonance Imaging, Cine - methods
  • Male
  • Medical sciences
  • Middle Aged
  • Mortality
  • MRI
  • Nephrology. Urinary tract diseases
  • Nephropathies. Renovascular diseases. Renal failure
  • nuclear cardiology
  • pharmacokinetics/pharmacodynamics
  • phosphate
  • Phosphates - blood
  • Prognosis
  • pulmonary valve disease
  • renal diseases
  • Renal failure
  • renin–angiotensin system
  • Reproducibility of Results
  • risk factors
  • Severity of Illness Index
  • tissue Doppler
  • transthoracic
  • tricuspid valve disease
  • Urinary system involvement in other diseases. Miscellaneous
  • valve disease
  • ventricular function
  • Ventricular Function, Left - physiology
  • ventricular hypertrophy
ispartof: Heart (British Cardiac Society), 2012, Vol.98 (3), p.219-224
description: ObjectiveTo explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD).DesignA cross-sectional observational study.SettingSingle centre.Patients208 patients with stage 2 to stage 4 non-diabetic CKD.InterventionsArterial stiffness was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance was used to determine LVM.Main outcome measureRelationship between serum phosphate, aortic PWV and LVM.ResultsMean age was 54±13 years, mean glomerular filtration rate was 50±15 ml/min/1.73 m2, mean serum phosphate was 1.11±0.21 mmol/l and mean PWV was 8.6±2.1 m/s. When the cohort was divided into quartiles according to serum phosphate, LVM increased across quartiles (p=0.04), with no significant differences in age, kidney function, blood pressure or PWV. Serum phosphate correlated with LVM (r=0.173; p=0.01), but PWV did not (p=0.2). In a regression model containing gender, serum phosphate, office systolic blood pressure, albumin/creatinine ratio and haemoglobin, 30% of the variation in LVM was explained (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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titleSerum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study
sourceAlma/SFX Local Collection
creatorChue, Colin D ; Edwards, Nicola C ; Moody, William E ; Steeds, Richard P ; Townend, Jonathan N ; Ferro, Charles J
creatorcontribChue, Colin D ; Edwards, Nicola C ; Moody, William E ; Steeds, Richard P ; Townend, Jonathan N ; Ferro, Charles J
descriptionObjectiveTo explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD).DesignA cross-sectional observational study.SettingSingle centre.Patients208 patients with stage 2 to stage 4 non-diabetic CKD.InterventionsArterial stiffness was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance was used to determine LVM.Main outcome measureRelationship between serum phosphate, aortic PWV and LVM.ResultsMean age was 54±13 years, mean glomerular filtration rate was 50±15 ml/min/1.73 m2, mean serum phosphate was 1.11±0.21 mmol/l and mean PWV was 8.6±2.1 m/s. When the cohort was divided into quartiles according to serum phosphate, LVM increased across quartiles (p=0.04), with no significant differences in age, kidney function, blood pressure or PWV. Serum phosphate correlated with LVM (r=0.173; p=0.01), but PWV did not (p=0.2). In a regression model containing gender, serum phosphate, office systolic blood pressure, albumin/creatinine ratio and haemoglobin, 30% of the variation in LVM was explained (p<0.0005), with serum phosphate accounting for 5% of the variance.ConclusionSerum phosphate is independently associated with LVM in patients with CKD. Interventional studies are required to determine whether this association is causative and whether reducing phosphate exposure reduces LVM in this population.
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1EISSN: 1468-201X
2DOI: 10.1136/heartjnl-2011-300570
3PMID: 22021416
languageeng
publisherLondon: BMJ Publishing Group Ltd and British Cardiovascular Society
subjectacute coronary syndrome ; acute myocardial infarction ; aortic disease ; Aortic stiffness ; aortic valve disease ; Arterial occlusions ; arterial wall morphology ; atrial fibrillation ; autonomic regulation ; Biological and medical sciences ; Biomarkers - blood ; Blood pressure ; cardiac MRI ; Cardiology. Vascular system ; cardiomyopathy ; Cardiovascular disease ; cardiovascular risk ; Care and treatment ; Chronic kidney failure ; Cross-Sectional Studies ; depression ; Diagnosis ; Disease Progression ; EBM ; echocardiography ; echocardiography (transoesophageal) ; endothelium ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; haemodynamics ; Heart attacks ; heart failure ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; Hypertrophy, Left Ventricular - blood ; Hypertrophy, Left Ventricular - diagnosis ; Hypertrophy, Left Ventricular - etiology ; imaging and diagnostics ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - physiopathology ; Kidneys ; left ventricular mass ; Magnetic Resonance Imaging, Cine - methods ; Male ; Medical sciences ; Middle Aged ; Mortality ; MRI ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; nuclear cardiology ; pharmacokinetics/pharmacodynamics ; phosphate ; Phosphates - blood ; Prognosis ; pulmonary valve disease ; renal diseases ; Renal failure ; renin–angiotensin system ; Reproducibility of Results ; risk factors ; Severity of Illness Index ; tissue Doppler ; transthoracic ; tricuspid valve disease ; Urinary system involvement in other diseases. Miscellaneous ; valve disease ; ventricular function ; Ventricular Function, Left - physiology ; ventricular hypertrophy
ispartofHeart (British Cardiac Society), 2012, Vol.98 (3), p.219-224
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02011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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1Edwards, Nicola C
2Moody, William E
3Steeds, Richard P
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5Ferro, Charles J
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descriptionObjectiveTo explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD).DesignA cross-sectional observational study.SettingSingle centre.Patients208 patients with stage 2 to stage 4 non-diabetic CKD.InterventionsArterial stiffness was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance was used to determine LVM.Main outcome measureRelationship between serum phosphate, aortic PWV and LVM.ResultsMean age was 54±13 years, mean glomerular filtration rate was 50±15 ml/min/1.73 m2, mean serum phosphate was 1.11±0.21 mmol/l and mean PWV was 8.6±2.1 m/s. When the cohort was divided into quartiles according to serum phosphate, LVM increased across quartiles (p=0.04), with no significant differences in age, kidney function, blood pressure or PWV. Serum phosphate correlated with LVM (r=0.173; p=0.01), but PWV did not (p=0.2). In a regression model containing gender, serum phosphate, office systolic blood pressure, albumin/creatinine ratio and haemoglobin, 30% of the variation in LVM was explained (p<0.0005), with serum phosphate accounting for 5% of the variance.ConclusionSerum phosphate is independently associated with LVM in patients with CKD. Interventional studies are required to determine whether this association is causative and whether reducing phosphate exposure reduces LVM in this population.
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1acute myocardial infarction
2aortic disease
3Aortic stiffness
4aortic valve disease
5Arterial occlusions
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7atrial fibrillation
8autonomic regulation
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11Blood pressure
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29Glomerular Filtration Rate
30haemodynamics
31Heart attacks
32heart failure
33Heart Ventricles - pathology
34Heart Ventricles - physiopathology
35Humans
36Hypertrophy, Left Ventricular - blood
37Hypertrophy, Left Ventricular - diagnosis
38Hypertrophy, Left Ventricular - etiology
39imaging and diagnostics
40Kidney Failure, Chronic - blood
41Kidney Failure, Chronic - complications
42Kidney Failure, Chronic - physiopathology
43Kidneys
44left ventricular mass
45Magnetic Resonance Imaging, Cine - methods
46Male
47Medical sciences
48Middle Aged
49Mortality
50MRI
51Nephrology. Urinary tract diseases
52Nephropathies. Renovascular diseases. Renal failure
53nuclear cardiology
54pharmacokinetics/pharmacodynamics
55phosphate
56Phosphates - blood
57Prognosis
58pulmonary valve disease
59renal diseases
60Renal failure
61renin–angiotensin system
62Reproducibility of Results
63risk factors
64Severity of Illness Index
65tissue Doppler
66transthoracic
67tricuspid valve disease
68Urinary system involvement in other diseases. Miscellaneous
69valve disease
70ventricular function
71Ventricular Function, Left - physiology
72ventricular hypertrophy
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titleSerum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study
authorChue, Colin D ; Edwards, Nicola C ; Moody, William E ; Steeds, Richard P ; Townend, Jonathan N ; Ferro, Charles J
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abstractObjectiveTo explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD).DesignA cross-sectional observational study.SettingSingle centre.Patients208 patients with stage 2 to stage 4 non-diabetic CKD.InterventionsArterial stiffness was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance was used to determine LVM.Main outcome measureRelationship between serum phosphate, aortic PWV and LVM.ResultsMean age was 54±13 years, mean glomerular filtration rate was 50±15 ml/min/1.73 m2, mean serum phosphate was 1.11±0.21 mmol/l and mean PWV was 8.6±2.1 m/s. When the cohort was divided into quartiles according to serum phosphate, LVM increased across quartiles (p=0.04), with no significant differences in age, kidney function, blood pressure or PWV. Serum phosphate correlated with LVM (r=0.173; p=0.01), but PWV did not (p=0.2). In a regression model containing gender, serum phosphate, office systolic blood pressure, albumin/creatinine ratio and haemoglobin, 30% of the variation in LVM was explained (p<0.0005), with serum phosphate accounting for 5% of the variance.ConclusionSerum phosphate is independently associated with LVM in patients with CKD. Interventional studies are required to determine whether this association is causative and whether reducing phosphate exposure reduces LVM in this population.
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pmid22021416
doi10.1136/heartjnl-2011-300570