schliessen

Filtern

 

Bibliotheken

Lipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children

Dyslipidemia is observed among older children and adults with HIV. We examined nonfasting cholesterol and triglycerides in two groups of 12-23-month-old Latin American children - HIV-infected vs. HIV-exposed but uninfected (HEU). HIV-infected and HEU children in Latin America and Jamaica were enroll... Full description

Journal Title: AIDS (London) 2012, Vol.26 (2), p.235-240
Main Author: HAZRA, Rohan
Other Authors: COHEN, Rachel A , GONIN, Rene , MONTEIRO, Jacqueline P , HOFER, Cristina B , NEGRA, Marinella D , RUZ, Noris P
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_920795119
title: Lipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children
format: Article
creator:
  • HAZRA, Rohan
  • COHEN, Rachel A
  • GONIN, Rene
  • MONTEIRO, Jacqueline P
  • HOFER, Cristina B
  • NEGRA, Marinella D
  • RUZ, Noris P
subjects:
  • AIDS/HIV
  • Antibiotics. Antiinfectious agents. Antiparasitic agents
  • Antiretroviral Therapy, Highly Active - adverse effects
  • Antiviral agents
  • Biological and medical sciences
  • Cholesterol - blood
  • Cohort Studies
  • Female
  • HIV Infections - blood
  • HIV Infections - drug therapy
  • HIV Infections - epidemiology
  • HIV Protease Inhibitors - administration & dosage
  • HIV Protease Inhibitors - adverse effects
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Hyperlipidemias - blood
  • Hyperlipidemias - chemically induced
  • Hyperlipidemias - epidemiology
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infant
  • Infectious diseases
  • Jamaica - epidemiology
  • Latin America - epidemiology
  • Male
  • Medical sciences
  • Pharmacology. Drug treatments
  • Prevalence
  • Triglycerides - blood
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
ispartof: AIDS (London), 2012, Vol.26 (2), p.235-240
description: Dyslipidemia is observed among older children and adults with HIV. We examined nonfasting cholesterol and triglycerides in two groups of 12-23-month-old Latin American children - HIV-infected vs. HIV-exposed but uninfected (HEU). HIV-infected and HEU children in Latin America and Jamaica were enrolled in an observational cohort. Eligibility for this analysis required having cholesterol and triglyceride results available during the second year of life. HIV-infected (n = 83) children were slightly older at the time of lipid testing than the HEU (n = 681). Forty percent of the HIV-infected children were on protease inhibitor-based antiretroviral therapy (ART); 41% were not on ART. There was no statistically significant difference in mean cholesterol concentrations (mg/dl) by HIV status; however, the HIV-infected children had higher mean triglyceride concentrations. The prevalence of high cholesterol (>200  mg/dl) and high triglycerides (>110 mg/dl) was higher among the HIV-infected vs. HEU. Among the HIV-infected children, mean cholesterol and triglyceride concentrations varied by ART. Children receiving no ART had a significantly lower mean cholesterol concentration. Those receiving protease inhibitor-containing ART had a significantly higher mean triglyceride concentration compared to the other two antiretroviral regimen groups. A greater proportion of HIV-infected children at 12-23 months have hyperlipidemia when compared to HEU children, with the highest triglyceride concentrations observed among those receiving protease inhibitor-containing ART, and the lowest cholesterol levels among those not receiving ART. Implications of these findings will require continued follow-up of HIV-infected children who initiate therapy early in life.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.3306923
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_920795119
sourceformatXML
sourcesystemPC
sourcerecordid918576415
originalsourceidFETCH-LOGICAL-1364t-a5829a3010374021093d543f37326c07b672a7c13e455d9a7afcd248e08716960
addsrcrecordideNqFkV9rFTEQxYMo9rb6DUTyIj5tnfzbJI-XVm3hQilUX5fcZGIju9lrsrfYb9-UXiv44tMwM78zw-EQ8o7BKQOrP12vz09hC0yg4EbI4FX0L8iKSS06pTR7SVbAe9tZoeGIHNf6EwAUGPOaHHEOYHolV2TapF0KdMQ7HCtNmS63SCv6OQd6j67QOdIxRaRumvMPenH5vUs5ol8wUNeYxwH-3s219fv8vNq4pd1aT1iSd5n62zSGgvkNeRXdWPHtoZ6Qb18-35xddJurr5dn603HRC-XzinDrRPAQGgJvNkVQUkRhRa896C3veZO-2ZdKhWs0y76wKVBMJr1tocT8vHp7q7Mv_ZYl2FK1eM4uozzvg6Wg7aKMft_khmle8lUI-UT6ctca8E47EqaXLkfGAyPiQwtkeHfRJrs_eHBfjtheBb9iaABHw6Aq96NsbjsU_3LKWkMBwEP-7uTFQ
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid918576415
display
typearticle
titleLipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children
creatorHAZRA, Rohan ; COHEN, Rachel A ; GONIN, Rene ; MONTEIRO, Jacqueline P ; HOFER, Cristina B ; NEGRA, Marinella D ; RUZ, Noris P
creatorcontribHAZRA, Rohan ; COHEN, Rachel A ; GONIN, Rene ; MONTEIRO, Jacqueline P ; HOFER, Cristina B ; NEGRA, Marinella D ; RUZ, Noris P ; NISDI Pediatric Study Group 2011
descriptionDyslipidemia is observed among older children and adults with HIV. We examined nonfasting cholesterol and triglycerides in two groups of 12-23-month-old Latin American children - HIV-infected vs. HIV-exposed but uninfected (HEU). HIV-infected and HEU children in Latin America and Jamaica were enrolled in an observational cohort. Eligibility for this analysis required having cholesterol and triglyceride results available during the second year of life. HIV-infected (n = 83) children were slightly older at the time of lipid testing than the HEU (n = 681). Forty percent of the HIV-infected children were on protease inhibitor-based antiretroviral therapy (ART); 41% were not on ART. There was no statistically significant difference in mean cholesterol concentrations (mg/dl) by HIV status; however, the HIV-infected children had higher mean triglyceride concentrations. The prevalence of high cholesterol (>200  mg/dl) and high triglycerides (>110 mg/dl) was higher among the HIV-infected vs. HEU. Among the HIV-infected children, mean cholesterol and triglyceride concentrations varied by ART. Children receiving no ART had a significantly lower mean cholesterol concentration. Those receiving protease inhibitor-containing ART had a significantly higher mean triglyceride concentration compared to the other two antiretroviral regimen groups. A greater proportion of HIV-infected children at 12-23 months have hyperlipidemia when compared to HEU children, with the highest triglyceride concentrations observed among those receiving protease inhibitor-containing ART, and the lowest cholesterol levels among those not receiving ART. Implications of these findings will require continued follow-up of HIV-infected children who initiate therapy early in life.
identifier
0ISSN: 0269-9370
1EISSN: 1473-5571
2DOI: 10.1097/QAD.0b013e32834dc5fc
3PMID: 22008654
languageeng
publisherHagerstown, MD: Lippincott Williams & Wilkins
subjectAIDS/HIV ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral Therapy, Highly Active - adverse effects ; Antiviral agents ; Biological and medical sciences ; Cholesterol - blood ; Cohort Studies ; Female ; HIV Infections - blood ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Protease Inhibitors - administration & dosage ; HIV Protease Inhibitors - adverse effects ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - chemically induced ; Hyperlipidemias - epidemiology ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Infectious diseases ; Jamaica - epidemiology ; Latin America - epidemiology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Prevalence ; Triglycerides - blood ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
ispartofAIDS (London), 2012, Vol.26 (2), p.235-240
rights2015 INIST-CNRS
lds50peer_reviewed
citesFETCH-LOGICAL-1364t-a5829a3010374021093d543f37326c07b672a7c13e455d9a7afcd248e08716960
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25488203$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22008654$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0HAZRA, Rohan
1COHEN, Rachel A
2GONIN, Rene
3MONTEIRO, Jacqueline P
4HOFER, Cristina B
5NEGRA, Marinella D
6RUZ, Noris P
7NISDI Pediatric Study Group 2011
title
0Lipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children
1AIDS (London)
addtitleAIDS
descriptionDyslipidemia is observed among older children and adults with HIV. We examined nonfasting cholesterol and triglycerides in two groups of 12-23-month-old Latin American children - HIV-infected vs. HIV-exposed but uninfected (HEU). HIV-infected and HEU children in Latin America and Jamaica were enrolled in an observational cohort. Eligibility for this analysis required having cholesterol and triglyceride results available during the second year of life. HIV-infected (n = 83) children were slightly older at the time of lipid testing than the HEU (n = 681). Forty percent of the HIV-infected children were on protease inhibitor-based antiretroviral therapy (ART); 41% were not on ART. There was no statistically significant difference in mean cholesterol concentrations (mg/dl) by HIV status; however, the HIV-infected children had higher mean triglyceride concentrations. The prevalence of high cholesterol (>200  mg/dl) and high triglycerides (>110 mg/dl) was higher among the HIV-infected vs. HEU. Among the HIV-infected children, mean cholesterol and triglyceride concentrations varied by ART. Children receiving no ART had a significantly lower mean cholesterol concentration. Those receiving protease inhibitor-containing ART had a significantly higher mean triglyceride concentration compared to the other two antiretroviral regimen groups. A greater proportion of HIV-infected children at 12-23 months have hyperlipidemia when compared to HEU children, with the highest triglyceride concentrations observed among those receiving protease inhibitor-containing ART, and the lowest cholesterol levels among those not receiving ART. Implications of these findings will require continued follow-up of HIV-infected children who initiate therapy early in life.
subject
0AIDS/HIV
1Antibiotics. Antiinfectious agents. Antiparasitic agents
2Antiretroviral Therapy, Highly Active - adverse effects
3Antiviral agents
4Biological and medical sciences
5Cholesterol - blood
6Cohort Studies
7Female
8HIV Infections - blood
9HIV Infections - drug therapy
10HIV Infections - epidemiology
11HIV Protease Inhibitors - administration & dosage
12HIV Protease Inhibitors - adverse effects
13Human immunodeficiency virus
14Human viral diseases
15Humans
16Hyperlipidemias - blood
17Hyperlipidemias - chemically induced
18Hyperlipidemias - epidemiology
19Immunodeficiencies
20Immunodeficiencies. Immunoglobulinopathies
21Immunopathology
22Infant
23Infectious diseases
24Jamaica - epidemiology
25Latin America - epidemiology
26Male
27Medical sciences
28Pharmacology. Drug treatments
29Prevalence
30Triglycerides - blood
31Viral diseases
32Viral diseases of the lymphoid tissue and the blood. Aids
issn
00269-9370
11473-5571
fulltextfalse
rsrctypearticle
creationdate2012
recordtypearticle
recordideNqFkV9rFTEQxYMo9rb6DUTyIj5tnfzbJI-XVm3hQilUX5fcZGIju9lrsrfYb9-UXiv44tMwM78zw-EQ8o7BKQOrP12vz09hC0yg4EbI4FX0L8iKSS06pTR7SVbAe9tZoeGIHNf6EwAUGPOaHHEOYHolV2TapF0KdMQ7HCtNmS63SCv6OQd6j67QOdIxRaRumvMPenH5vUs5ol8wUNeYxwH-3s219fv8vNq4pd1aT1iSd5n62zSGgvkNeRXdWPHtoZ6Qb18-35xddJurr5dn603HRC-XzinDrRPAQGgJvNkVQUkRhRa896C3veZO-2ZdKhWs0y76wKVBMJr1tocT8vHp7q7Mv_ZYl2FK1eM4uozzvg6Wg7aKMft_khmle8lUI-UT6ctca8E47EqaXLkfGAyPiQwtkeHfRJrs_eHBfjtheBb9iaABHw6Aq96NsbjsU_3LKWkMBwEP-7uTFQ
startdate2012
enddate2012
creator
0HAZRA, Rohan
1COHEN, Rachel A
2GONIN, Rene
3MONTEIRO, Jacqueline P
4HOFER, Cristina B
5NEGRA, Marinella D
6RUZ, Noris P
generalLippincott Williams & Wilkins
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97X8
107T5
117U9
12H94
sort
creationdate2012
titleLipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children
authorHAZRA, Rohan ; COHEN, Rachel A ; GONIN, Rene ; MONTEIRO, Jacqueline P ; HOFER, Cristina B ; NEGRA, Marinella D ; RUZ, Noris P
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1364t-a5829a3010374021093d543f37326c07b672a7c13e455d9a7afcd248e08716960
rsrctypearticles
prefilterarticles
languageeng
creationdate2012
topic
0AIDS/HIV
1Antibiotics. Antiinfectious agents. Antiparasitic agents
2Antiretroviral Therapy, Highly Active - adverse effects
3Antiviral agents
4Biological and medical sciences
5Cholesterol - blood
6Cohort Studies
7Female
8HIV Infections - blood
9HIV Infections - drug therapy
10HIV Infections - epidemiology
11HIV Protease Inhibitors - administration & dosage
12HIV Protease Inhibitors - adverse effects
13Human immunodeficiency virus
14Human viral diseases
15Humans
16Hyperlipidemias - blood
17Hyperlipidemias - chemically induced
18Hyperlipidemias - epidemiology
19Immunodeficiencies
20Immunodeficiencies. Immunoglobulinopathies
21Immunopathology
22Infant
23Infectious diseases
24Jamaica - epidemiology
25Latin America - epidemiology
26Male
27Medical sciences
28Pharmacology. Drug treatments
29Prevalence
30Triglycerides - blood
31Viral diseases
32Viral diseases of the lymphoid tissue and the blood. Aids
toplevelpeer_reviewed
creatorcontrib
0HAZRA, Rohan
1COHEN, Rachel A
2GONIN, Rene
3MONTEIRO, Jacqueline P
4HOFER, Cristina B
5NEGRA, Marinella D
6RUZ, Noris P
7NISDI Pediatric Study Group 2011
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8MEDLINE - Academic
9Immunology Abstracts
10Virology and AIDS Abstracts
11AIDS and Cancer Research Abstracts
jtitleAIDS (London)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0HAZRA, Rohan
1COHEN, Rachel A
2GONIN, Rene
3MONTEIRO, Jacqueline P
4HOFER, Cristina B
5NEGRA, Marinella D
6RUZ, Noris P
aucorpNISDI Pediatric Study Group 2011
formatjournal
genrearticle
ristypeJOUR
atitleLipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children
jtitleAIDS (London)
addtitleAIDS
date2012
risdate2012
volume26
issue2
spage235
epage240
pages235-240
issn0269-9370
eissn1473-5571
abstractDyslipidemia is observed among older children and adults with HIV. We examined nonfasting cholesterol and triglycerides in two groups of 12-23-month-old Latin American children - HIV-infected vs. HIV-exposed but uninfected (HEU). HIV-infected and HEU children in Latin America and Jamaica were enrolled in an observational cohort. Eligibility for this analysis required having cholesterol and triglyceride results available during the second year of life. HIV-infected (n = 83) children were slightly older at the time of lipid testing than the HEU (n = 681). Forty percent of the HIV-infected children were on protease inhibitor-based antiretroviral therapy (ART); 41% were not on ART. There was no statistically significant difference in mean cholesterol concentrations (mg/dl) by HIV status; however, the HIV-infected children had higher mean triglyceride concentrations. The prevalence of high cholesterol (>200  mg/dl) and high triglycerides (>110 mg/dl) was higher among the HIV-infected vs. HEU. Among the HIV-infected children, mean cholesterol and triglyceride concentrations varied by ART. Children receiving no ART had a significantly lower mean cholesterol concentration. Those receiving protease inhibitor-containing ART had a significantly higher mean triglyceride concentration compared to the other two antiretroviral regimen groups. A greater proportion of HIV-infected children at 12-23 months have hyperlipidemia when compared to HEU children, with the highest triglyceride concentrations observed among those receiving protease inhibitor-containing ART, and the lowest cholesterol levels among those not receiving ART. Implications of these findings will require continued follow-up of HIV-infected children who initiate therapy early in life.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid22008654
doi10.1097/QAD.0b013e32834dc5fc