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The Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes

The cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognize... Full description

Journal Title: Annual review of nutrition 2011-08-21, Vol.31 (1), p.203-234
Main Author: Madden, Jacqueline
Other Authors: Williams, Christine M , Calder, Philip C , Lietz, Georg , Miles, Elizabeth A , Cordell, Heather , Mathers, John C , Minihane, Anne Marie
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0199-9885
Link: https://www.ncbi.nlm.nih.gov/pubmed/21568708
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title: The Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes
format: Article
creator:
  • Madden, Jacqueline
  • Williams, Christine M
  • Calder, Philip C
  • Lietz, Georg
  • Miles, Elizabeth A
  • Cordell, Heather
  • Mathers, John C
  • Minihane, Anne Marie
subjects:
  • Biomarkers - blood
  • Cardiotonic Agents - analysis
  • Cardiotonic Agents - metabolism
  • Cardiotonic Agents - therapeutic use
  • Cardiovascular diseases
  • Cardiovascular Diseases - blood
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - prevention & control
  • Docosahexaenoic Acids - analysis
  • Docosahexaenoic Acids - metabolism
  • Docosahexaenoic Acids - therapeutic use
  • Eicosapentaenoic Acid - analysis
  • Eicosapentaenoic Acid - metabolism
  • Eicosapentaenoic Acid - therapeutic use
  • Fatty Acids, Omega-3 - analysis
  • Fatty Acids, Omega-3 - metabolism
  • Fatty Acids, Omega-3 - therapeutic use
  • Fish oils
  • Fish Oils - chemistry
  • Fish Oils - therapeutic use
  • Genetic aspects
  • Genetic Association Studies
  • Genetic variation
  • Health aspects
  • Humans
  • Observations
  • Omega-3 fatty acids
  • Polymorphism, Genetic
  • Risk Factors
ispartof: Annual review of nutrition, 2011-08-21, Vol.31 (1), p.203-234
description: The cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype × LC-n3 PUFA × phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0199-9885
fulltext: fulltext
issn:
  • 0199-9885
  • 1545-4312
url: Link


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titleThe Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes
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creatorMadden, Jacqueline ; Williams, Christine M ; Calder, Philip C ; Lietz, Georg ; Miles, Elizabeth A ; Cordell, Heather ; Mathers, John C ; Minihane, Anne Marie
creatorcontribMadden, Jacqueline ; Williams, Christine M ; Calder, Philip C ; Lietz, Georg ; Miles, Elizabeth A ; Cordell, Heather ; Mathers, John C ; Minihane, Anne Marie
descriptionThe cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype × LC-n3 PUFA × phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations.
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languageeng
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subjectBiomarkers - blood ; Cardiotonic Agents - analysis ; Cardiotonic Agents - metabolism ; Cardiotonic Agents - therapeutic use ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - prevention & control ; Docosahexaenoic Acids - analysis ; Docosahexaenoic Acids - metabolism ; Docosahexaenoic Acids - therapeutic use ; Eicosapentaenoic Acid - analysis ; Eicosapentaenoic Acid - metabolism ; Eicosapentaenoic Acid - therapeutic use ; Fatty Acids, Omega-3 - analysis ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Omega-3 - therapeutic use ; Fish oils ; Fish Oils - chemistry ; Fish Oils - therapeutic use ; Genetic aspects ; Genetic Association Studies ; Genetic variation ; Health aspects ; Humans ; Observations ; Omega-3 fatty acids ; Polymorphism, Genetic ; Risk Factors
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descriptionThe cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype × LC-n3 PUFA × phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations.
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7Cardiovascular Diseases - genetics
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titleThe Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes
authorMadden, Jacqueline ; Williams, Christine M ; Calder, Philip C ; Lietz, Georg ; Miles, Elizabeth A ; Cordell, Heather ; Mathers, John C ; Minihane, Anne Marie
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abstractThe cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype × LC-n3 PUFA × phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations.
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