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Fibrinogen as a key regulator of inflammation in disease

The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiolo... Full description

Journal Title: Seminars in immunopathology 2011, Vol.34 (1), p.43-62
Main Author: Davalos, Dimitrios
Other Authors: Akassoglou, Katerina
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1863-2297
Link: https://www.ncbi.nlm.nih.gov/pubmed/22037947
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title: Fibrinogen as a key regulator of inflammation in disease
format: Article
creator:
  • Davalos, Dimitrios
  • Akassoglou, Katerina
subjects:
  • Alzheimer Disease - genetics
  • Alzheimer Disease - immunology
  • Alzheimer Disease - metabolism
  • Alzheimer's disease
  • Animals
  • Anticoagulants (Medicine)
  • Arthritis, Rheumatoid - genetics
  • Arthritis, Rheumatoid - immunology
  • Arthritis, Rheumatoid - metabolism
  • Atherosclerosis
  • Autoimmunity
  • Bacterial infections
  • Bacterial Infections - genetics
  • Bacterial Infections - immunology
  • Bacterial Infections - metabolism
  • Biomedical and Life Sciences
  • Biomedicine
  • Blood Coagulation - genetics
  • Blood Coagulation - immunology
  • Brain Injuries - genetics
  • Brain Injuries - immunology
  • Brain Injuries - metabolism
  • Brain injury
  • Cancer
  • Coagulation
  • Coagulation factors
  • Colitis
  • Colitis - genetics
  • Colitis - immunology
  • Colitis - metabolism
  • Duchenne's muscular dystrophy
  • Fibrin
  • Fibrinogen
  • Fibrinogen - genetics
  • Fibrinogen - immunology
  • Fibrinogen - metabolism
  • Fibrosis
  • Genetic research
  • hemostasis
  • Humans
  • Immunology
  • Infection
  • Inflammation
  • Inflammation - genetics
  • Inflammation - immunology
  • Inflammation - metabolism
  • Inflammatory diseases
  • Internal Medicine
  • Kidney
  • Kidney Diseases - genetics
  • Kidney Diseases - immunology
  • Kidney Diseases - metabolism
  • Macrophages
  • Molecular modelling
  • Multiple sclerosis
  • Multiple Sclerosis - genetics
  • Multiple Sclerosis - immunology
  • Multiple Sclerosis - metabolism
  • Muscular Dystrophy, Duchenne - genetics
  • Muscular Dystrophy, Duchenne - immunology
  • Muscular Dystrophy, Duchenne - metabolism
  • Neoplasms - genetics
  • Neoplasms - immunology
  • Neoplasms - metabolism
  • Nervous system diseases
  • Neurodegenerative diseases
  • Oncology, Experimental
  • Pulmonary Fibrosis - genetics
  • Pulmonary Fibrosis - immunology
  • Pulmonary Fibrosis - metabolism
  • Review
  • Rheumatoid arthritis
  • Rheumatoid factor
  • Signal transduction
  • Spinal Cord Injuries - genetics
  • Spinal Cord Injuries - immunology
  • Spinal Cord Injuries - metabolism
  • Spinal cord injury
  • Stroke
  • Stroke - genetics
  • Stroke - immunology
  • Stroke - metabolism
  • Therapeutic applications
  • Thrombin
  • Thrombin - genetics
  • Thrombin - immunology
  • Thrombin - metabolism
  • Thromboplastin - genetics
  • Thromboplastin - immunology
  • Thromboplastin - metabolism
  • Thrombosis
  • Tissue factor
  • Traumatic brain injury
  • Vascular Diseases - genetics
  • Vascular Diseases - immunology
  • Vascular Diseases - metabolism
ispartof: Seminars in immunopathology, 2011, Vol.34 (1), p.43-62
description: The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification of novel molecular mechanisms linking coagulation and inflammation has highlighted factors of the coagulation cascade as new targets for therapeutic intervention in a wide range of inflammatory human diseases. In particular, a proinflammatory role for fibrinogen has been reported in vascular wall disease, stroke, spinal cord injury, brain trauma, multiple sclerosis, Alzheimer’s disease, rheumatoid arthritis, bacterial infection, colitis, lung and kidney fibrosis, Duchenne muscular dystrophy, and several types of cancer. Genetic and pharmacologic studies have unraveled pivotal roles for fibrinogen in determining the extent of local or systemic inflammation. As cellular and molecular mechanisms for fibrinogen functions in tissues are identified, the role of fibrinogen is evolving from a marker of vascular rapture to a multi-faceted signaling molecule with a wide spectrum of functions that can tip the balance between hemostasis and thrombosis, coagulation and fibrosis, protection from infection and extensive inflammation, and eventually life and death. This review will discuss some of the main molecular links between coagulation and inflammation and will focus on the role of fibrinogen in inflammatory disease highlighting its unique structural properties, cellular targets, and signal transduction pathways that make it a potent proinflammatory mediator and a potential therapeutic target.
language: eng
source:
identifier: ISSN: 1863-2297
fulltext: no_fulltext
issn:
  • 1863-2297
  • 1863-2300
url: Link


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titleFibrinogen as a key regulator of inflammation in disease
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descriptionThe interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification of novel molecular mechanisms linking coagulation and inflammation has highlighted factors of the coagulation cascade as new targets for therapeutic intervention in a wide range of inflammatory human diseases. In particular, a proinflammatory role for fibrinogen has been reported in vascular wall disease, stroke, spinal cord injury, brain trauma, multiple sclerosis, Alzheimer’s disease, rheumatoid arthritis, bacterial infection, colitis, lung and kidney fibrosis, Duchenne muscular dystrophy, and several types of cancer. Genetic and pharmacologic studies have unraveled pivotal roles for fibrinogen in determining the extent of local or systemic inflammation. As cellular and molecular mechanisms for fibrinogen functions in tissues are identified, the role of fibrinogen is evolving from a marker of vascular rapture to a multi-faceted signaling molecule with a wide spectrum of functions that can tip the balance between hemostasis and thrombosis, coagulation and fibrosis, protection from infection and extensive inflammation, and eventually life and death. This review will discuss some of the main molecular links between coagulation and inflammation and will focus on the role of fibrinogen in inflammatory disease highlighting its unique structural properties, cellular targets, and signal transduction pathways that make it a potent proinflammatory mediator and a potential therapeutic target.
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languageeng
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subjectAlzheimer Disease - genetics ; Alzheimer Disease - immunology ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Animals ; Anticoagulants (Medicine) ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - metabolism ; Atherosclerosis ; Autoimmunity ; Bacterial infections ; Bacterial Infections - genetics ; Bacterial Infections - immunology ; Bacterial Infections - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Blood Coagulation - genetics ; Blood Coagulation - immunology ; Brain Injuries - genetics ; Brain Injuries - immunology ; Brain Injuries - metabolism ; Brain injury ; Cancer ; Coagulation ; Coagulation factors ; Colitis ; Colitis - genetics ; Colitis - immunology ; Colitis - metabolism ; Duchenne's muscular dystrophy ; Fibrin ; Fibrinogen ; Fibrinogen - genetics ; Fibrinogen - immunology ; Fibrinogen - metabolism ; Fibrosis ; Genetic research ; hemostasis ; Humans ; Immunology ; Infection ; Inflammation ; Inflammation - genetics ; Inflammation - immunology ; Inflammation - metabolism ; Inflammatory diseases ; Internal Medicine ; Kidney ; Kidney Diseases - genetics ; Kidney Diseases - immunology ; Kidney Diseases - metabolism ; Macrophages ; Molecular modelling ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Multiple Sclerosis - immunology ; Multiple Sclerosis - metabolism ; Muscular Dystrophy, Duchenne - genetics ; Muscular Dystrophy, Duchenne - immunology ; Muscular Dystrophy, Duchenne - metabolism ; Neoplasms - genetics ; Neoplasms - immunology ; Neoplasms - metabolism ; Nervous system diseases ; Neurodegenerative diseases ; Oncology, Experimental ; Pulmonary Fibrosis - genetics ; Pulmonary Fibrosis - immunology ; Pulmonary Fibrosis - metabolism ; Review ; Rheumatoid arthritis ; Rheumatoid factor ; Signal transduction ; Spinal Cord Injuries - genetics ; Spinal Cord Injuries - immunology ; Spinal Cord Injuries - metabolism ; Spinal cord injury ; Stroke ; Stroke - genetics ; Stroke - immunology ; Stroke - metabolism ; Therapeutic applications ; Thrombin ; Thrombin - genetics ; Thrombin - immunology ; Thrombin - metabolism ; Thromboplastin - genetics ; Thromboplastin - immunology ; Thromboplastin - metabolism ; Thrombosis ; Tissue factor ; Traumatic brain injury ; Vascular Diseases - genetics ; Vascular Diseases - immunology ; Vascular Diseases - metabolism
ispartofSeminars in immunopathology, 2011, Vol.34 (1), p.43-62
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descriptionThe interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification of novel molecular mechanisms linking coagulation and inflammation has highlighted factors of the coagulation cascade as new targets for therapeutic intervention in a wide range of inflammatory human diseases. In particular, a proinflammatory role for fibrinogen has been reported in vascular wall disease, stroke, spinal cord injury, brain trauma, multiple sclerosis, Alzheimer’s disease, rheumatoid arthritis, bacterial infection, colitis, lung and kidney fibrosis, Duchenne muscular dystrophy, and several types of cancer. Genetic and pharmacologic studies have unraveled pivotal roles for fibrinogen in determining the extent of local or systemic inflammation. As cellular and molecular mechanisms for fibrinogen functions in tissues are identified, the role of fibrinogen is evolving from a marker of vascular rapture to a multi-faceted signaling molecule with a wide spectrum of functions that can tip the balance between hemostasis and thrombosis, coagulation and fibrosis, protection from infection and extensive inflammation, and eventually life and death. This review will discuss some of the main molecular links between coagulation and inflammation and will focus on the role of fibrinogen in inflammatory disease highlighting its unique structural properties, cellular targets, and signal transduction pathways that make it a potent proinflammatory mediator and a potential therapeutic target.
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0Alzheimer Disease - genetics
1Alzheimer Disease - immunology
2Alzheimer Disease - metabolism
3Alzheimer's disease
4Animals
5Anticoagulants (Medicine)
6Arthritis, Rheumatoid - genetics
7Arthritis, Rheumatoid - immunology
8Arthritis, Rheumatoid - metabolism
9Atherosclerosis
10Autoimmunity
11Bacterial infections
12Bacterial Infections - genetics
13Bacterial Infections - immunology
14Bacterial Infections - metabolism
15Biomedical and Life Sciences
16Biomedicine
17Blood Coagulation - genetics
18Blood Coagulation - immunology
19Brain Injuries - genetics
20Brain Injuries - immunology
21Brain Injuries - metabolism
22Brain injury
23Cancer
24Coagulation
25Coagulation factors
26Colitis
27Colitis - genetics
28Colitis - immunology
29Colitis - metabolism
30Duchenne's muscular dystrophy
31Fibrin
32Fibrinogen
33Fibrinogen - genetics
34Fibrinogen - immunology
35Fibrinogen - metabolism
36Fibrosis
37Genetic research
38hemostasis
39Humans
40Immunology
41Infection
42Inflammation
43Inflammation - genetics
44Inflammation - immunology
45Inflammation - metabolism
46Inflammatory diseases
47Internal Medicine
48Kidney
49Kidney Diseases - genetics
50Kidney Diseases - immunology
51Kidney Diseases - metabolism
52Macrophages
53Molecular modelling
54Multiple sclerosis
55Multiple Sclerosis - genetics
56Multiple Sclerosis - immunology
57Multiple Sclerosis - metabolism
58Muscular Dystrophy, Duchenne - genetics
59Muscular Dystrophy, Duchenne - immunology
60Muscular Dystrophy, Duchenne - metabolism
61Neoplasms - genetics
62Neoplasms - immunology
63Neoplasms - metabolism
64Nervous system diseases
65Neurodegenerative diseases
66Oncology, Experimental
67Pulmonary Fibrosis - genetics
68Pulmonary Fibrosis - immunology
69Pulmonary Fibrosis - metabolism
70Review
71Rheumatoid arthritis
72Rheumatoid factor
73Signal transduction
74Spinal Cord Injuries - genetics
75Spinal Cord Injuries - immunology
76Spinal Cord Injuries - metabolism
77Spinal cord injury
78Stroke
79Stroke - genetics
80Stroke - immunology
81Stroke - metabolism
82Therapeutic applications
83Thrombin
84Thrombin - genetics
85Thrombin - immunology
86Thrombin - metabolism
87Thromboplastin - genetics
88Thromboplastin - immunology
89Thromboplastin - metabolism
90Thrombosis
91Tissue factor
92Traumatic brain injury
93Vascular Diseases - genetics
94Vascular Diseases - immunology
95Vascular Diseases - metabolism
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titleFibrinogen as a key regulator of inflammation in disease
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0Alzheimer Disease - genetics
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5Anticoagulants (Medicine)
6Arthritis, Rheumatoid - genetics
7Arthritis, Rheumatoid - immunology
8Arthritis, Rheumatoid - metabolism
9Atherosclerosis
10Autoimmunity
11Bacterial infections
12Bacterial Infections - genetics
13Bacterial Infections - immunology
14Bacterial Infections - metabolism
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16Biomedicine
17Blood Coagulation - genetics
18Blood Coagulation - immunology
19Brain Injuries - genetics
20Brain Injuries - immunology
21Brain Injuries - metabolism
22Brain injury
23Cancer
24Coagulation
25Coagulation factors
26Colitis
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28Colitis - immunology
29Colitis - metabolism
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35Fibrinogen - metabolism
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48Kidney
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50Kidney Diseases - immunology
51Kidney Diseases - metabolism
52Macrophages
53Molecular modelling
54Multiple sclerosis
55Multiple Sclerosis - genetics
56Multiple Sclerosis - immunology
57Multiple Sclerosis - metabolism
58Muscular Dystrophy, Duchenne - genetics
59Muscular Dystrophy, Duchenne - immunology
60Muscular Dystrophy, Duchenne - metabolism
61Neoplasms - genetics
62Neoplasms - immunology
63Neoplasms - metabolism
64Nervous system diseases
65Neurodegenerative diseases
66Oncology, Experimental
67Pulmonary Fibrosis - genetics
68Pulmonary Fibrosis - immunology
69Pulmonary Fibrosis - metabolism
70Review
71Rheumatoid arthritis
72Rheumatoid factor
73Signal transduction
74Spinal Cord Injuries - genetics
75Spinal Cord Injuries - immunology
76Spinal Cord Injuries - metabolism
77Spinal cord injury
78Stroke
79Stroke - genetics
80Stroke - immunology
81Stroke - metabolism
82Therapeutic applications
83Thrombin
84Thrombin - genetics
85Thrombin - immunology
86Thrombin - metabolism
87Thromboplastin - genetics
88Thromboplastin - immunology
89Thromboplastin - metabolism
90Thrombosis
91Tissue factor
92Traumatic brain injury
93Vascular Diseases - genetics
94Vascular Diseases - immunology
95Vascular Diseases - metabolism
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abstractThe interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification of novel molecular mechanisms linking coagulation and inflammation has highlighted factors of the coagulation cascade as new targets for therapeutic intervention in a wide range of inflammatory human diseases. In particular, a proinflammatory role for fibrinogen has been reported in vascular wall disease, stroke, spinal cord injury, brain trauma, multiple sclerosis, Alzheimer’s disease, rheumatoid arthritis, bacterial infection, colitis, lung and kidney fibrosis, Duchenne muscular dystrophy, and several types of cancer. Genetic and pharmacologic studies have unraveled pivotal roles for fibrinogen in determining the extent of local or systemic inflammation. As cellular and molecular mechanisms for fibrinogen functions in tissues are identified, the role of fibrinogen is evolving from a marker of vascular rapture to a multi-faceted signaling molecule with a wide spectrum of functions that can tip the balance between hemostasis and thrombosis, coagulation and fibrosis, protection from infection and extensive inflammation, and eventually life and death. This review will discuss some of the main molecular links between coagulation and inflammation and will focus on the role of fibrinogen in inflammatory disease highlighting its unique structural properties, cellular targets, and signal transduction pathways that make it a potent proinflammatory mediator and a potential therapeutic target.
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pmid22037947
doi10.1007/s00281-011-0290-8