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Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective

Intravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many areas within the vasculature and beyond. Pharmacokinetics and biodistribution of these carriers are controlled by a complex array of interrelate... Full description

Journal Title: Annual review of pharmacology and toxicology 2012, Vol.52 (1), p.481-503
Main Author: MOGHIMI, S. M
Other Authors: HUNTER, A. C , ANDRESEN, T. L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Palo Alto, CA: Annual Reviews
ID: ISSN: 0362-1642
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recordid: cdi_proquest_miscellaneous_926888747
title: Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective
format: Article
creator:
  • MOGHIMI, S. M
  • HUNTER, A. C
  • ANDRESEN, T. L
subjects:
  • Animals
  • Biological and medical sciences
  • Computational Biology
  • Drug Design
  • Epigenomics - methods
  • Epigenomics - trends
  • General pharmacology
  • Humans
  • Medical sciences
  • Nanomedicine - methods
  • Nanoparticles - analysis
  • Nanoparticles - chemistry
  • Particle Size
  • Pharmaceutical Preparations
  • Pharmaceutical technology. Pharmaceutical industry
  • Pharmacokinetics
  • Pharmacology. Drug treatments
  • Tissue Distribution
ispartof: Annual review of pharmacology and toxicology, 2012, Vol.52 (1), p.481-503
description: Intravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many areas within the vasculature and beyond. Pharmacokinetics and biodistribution of these carriers are controlled by a complex array of interrelated core and interfacial physicochemical and biological factors. Pertinent to realizing therapeutic goals, definitive maps that establish the interdependency of nanoparticle size, shape, and surface characteristics in relation to interfacial forces, biodistribution, controlled drug release, excretion, and adverse effects must be outlined. These concepts are critically evaluated and an integrated perspective is provided on the basis of the recent application of nanoscience approaches to nanocarrier design and engineering. The future of this exciting field is bright; some regulatory-approved products are already on the market and many are in late-phase clinical trials. With concomitant advances in extensive computational knowledge of the genomics and epigenomics of interindividual variations in drug responses, the boundaries toward development of personalized nanomedicines can be pushed further.
language: eng
source:
identifier: ISSN: 0362-1642
fulltext: no_fulltext
issn:
  • 0362-1642
  • 1545-4304
url: Link


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descriptionIntravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many areas within the vasculature and beyond. Pharmacokinetics and biodistribution of these carriers are controlled by a complex array of interrelated core and interfacial physicochemical and biological factors. Pertinent to realizing therapeutic goals, definitive maps that establish the interdependency of nanoparticle size, shape, and surface characteristics in relation to interfacial forces, biodistribution, controlled drug release, excretion, and adverse effects must be outlined. These concepts are critically evaluated and an integrated perspective is provided on the basis of the recent application of nanoscience approaches to nanocarrier design and engineering. The future of this exciting field is bright; some regulatory-approved products are already on the market and many are in late-phase clinical trials. With concomitant advances in extensive computational knowledge of the genomics and epigenomics of interindividual variations in drug responses, the boundaries toward development of personalized nanomedicines can be pushed further.
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subjectAnimals ; Biological and medical sciences ; Computational Biology ; Drug Design ; Epigenomics - methods ; Epigenomics - trends ; General pharmacology ; Humans ; Medical sciences ; Nanomedicine - methods ; Nanoparticles - analysis ; Nanoparticles - chemistry ; Particle Size ; Pharmaceutical Preparations ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacokinetics ; Pharmacology. Drug treatments ; Tissue Distribution
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abstractIntravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many areas within the vasculature and beyond. Pharmacokinetics and biodistribution of these carriers are controlled by a complex array of interrelated core and interfacial physicochemical and biological factors. Pertinent to realizing therapeutic goals, definitive maps that establish the interdependency of nanoparticle size, shape, and surface characteristics in relation to interfacial forces, biodistribution, controlled drug release, excretion, and adverse effects must be outlined. These concepts are critically evaluated and an integrated perspective is provided on the basis of the recent application of nanoscience approaches to nanocarrier design and engineering. The future of this exciting field is bright; some regulatory-approved products are already on the market and many are in late-phase clinical trials. With concomitant advances in extensive computational knowledge of the genomics and epigenomics of interindividual variations in drug responses, the boundaries toward development of personalized nanomedicines can be pushed further.
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