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Drug Transporters in Drug Efficacy and Toxicity

Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug inte... Full description

Journal Title: Annual review of pharmacology and toxicology 2012, Vol.52 (1), p.249-273
Main Author: DEGORTER, M. K
Other Authors: XIA, C. Q , YANG, J. J , KIM, R. B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Palo Alto, CA: Annual Reviews
ID: ISSN: 0362-1642
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title: Drug Transporters in Drug Efficacy and Toxicity
format: Article
creator:
  • DEGORTER, M. K
  • XIA, C. Q
  • YANG, J. J
  • KIM, R. B
subjects:
  • Animals
  • ATP-Binding Cassette Transporters - metabolism
  • Biological and medical sciences
  • Biological Transport
  • Carrier Proteins - metabolism
  • Diet
  • Drug Design
  • Drug Interactions
  • Drug toxicity and drugs side effects treatment
  • Drug-Related Side Effects and Adverse Reactions
  • Food-Drug Interactions
  • Humans
  • Medical sciences
  • Miscellaneous (drug allergy, mutagens, teratogens...)
  • Models, Animal
  • Multidrug Resistance-Associated Proteins - metabolism
  • Pharmaceutical Preparations - metabolism
  • Pharmacogenetics
  • Pharmacology. Drug treatments
  • Polymorphism, Genetic
ispartof: Annual review of pharmacology and toxicology, 2012, Vol.52 (1), p.249-273
description: Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary constituents, can result in unexpected toxicity. Such effects are in part due to the interplay between various uptake and efflux transporters with overlapping functional capabilities that can manifest as marked interindividual variability in drug disposition in vivo. Here we review transporters of the solute carrier (SLC) and ATP-binding cassette (ABC) superfamilies considered to be of major importance in drug therapy and outline how understanding the expression, function, and genetic variation in such drug transporters will result in better strategies for optimal drug design and tissue targeting as well as reduce the risk for drug-drug interactions and adverse drug responses.
language: eng
source:
identifier: ISSN: 0362-1642
fulltext: no_fulltext
issn:
  • 0362-1642
  • 1545-4304
url: Link


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descriptionDrug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary constituents, can result in unexpected toxicity. Such effects are in part due to the interplay between various uptake and efflux transporters with overlapping functional capabilities that can manifest as marked interindividual variability in drug disposition in vivo. Here we review transporters of the solute carrier (SLC) and ATP-binding cassette (ABC) superfamilies considered to be of major importance in drug therapy and outline how understanding the expression, function, and genetic variation in such drug transporters will result in better strategies for optimal drug design and tissue targeting as well as reduce the risk for drug-drug interactions and adverse drug responses.
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subjectAnimals ; ATP-Binding Cassette Transporters - metabolism ; Biological and medical sciences ; Biological Transport ; Carrier Proteins - metabolism ; Diet ; Drug Design ; Drug Interactions ; Drug toxicity and drugs side effects treatment ; Drug-Related Side Effects and Adverse Reactions ; Food-Drug Interactions ; Humans ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Models, Animal ; Multidrug Resistance-Associated Proteins - metabolism ; Pharmaceutical Preparations - metabolism ; Pharmacogenetics ; Pharmacology. Drug treatments ; Polymorphism, Genetic
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descriptionDrug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary constituents, can result in unexpected toxicity. Such effects are in part due to the interplay between various uptake and efflux transporters with overlapping functional capabilities that can manifest as marked interindividual variability in drug disposition in vivo. Here we review transporters of the solute carrier (SLC) and ATP-binding cassette (ABC) superfamilies considered to be of major importance in drug therapy and outline how understanding the expression, function, and genetic variation in such drug transporters will result in better strategies for optimal drug design and tissue targeting as well as reduce the risk for drug-drug interactions and adverse drug responses.
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authorDEGORTER, M. K ; XIA, C. Q ; YANG, J. J ; KIM, R. B
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abstractDrug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary constituents, can result in unexpected toxicity. Such effects are in part due to the interplay between various uptake and efflux transporters with overlapping functional capabilities that can manifest as marked interindividual variability in drug disposition in vivo. Here we review transporters of the solute carrier (SLC) and ATP-binding cassette (ABC) superfamilies considered to be of major importance in drug therapy and outline how understanding the expression, function, and genetic variation in such drug transporters will result in better strategies for optimal drug design and tissue targeting as well as reduce the risk for drug-drug interactions and adverse drug responses.
copPalo Alto, CA
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doi10.1146/annurev-pharmtox-010611-134529