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Rheumatic heart disease

Summary Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250 000 deaths per year worldwide. The disease results from an abnormal autoimmu... Full description

Journal Title: The Lancet (British edition) 2012, Vol.379 (9819), p.953-964
Main Author: Marijon, Eloi, Dr
Other Authors: Mirabel, Mariana, MD , Celermajer, David S, Prof , Jouven, Xavier, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
Zum Text:
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recordid: cdi_proquest_miscellaneous_927832632
title: Rheumatic heart disease
format: Article
creator:
  • Marijon, Eloi, Dr
  • Mirabel, Mariana, MD
  • Celermajer, David S, Prof
  • Jouven, Xavier, Prof
subjects:
  • Abridged Index Medicus
  • Age
  • Antibiotics
  • Biological and medical sciences
  • Cardiovascular disease
  • Cardiovascular diseases
  • Care and treatment
  • Child
  • Complications and side effects
  • Coronary artery disease
  • Damage prevention
  • Developing countries
  • Disease control
  • Disease prevention
  • Echocardiography
  • Epidemiology
  • Fever
  • General aspects
  • Health aspects
  • Health risks
  • Heart
  • Heart diseases
  • Humans
  • Internal Medicine
  • LDCs
  • Medical sciences
  • Medical treatment
  • Morbidity
  • Mortality
  • Organs
  • Penicillin
  • Prevention
  • Prophylaxis
  • Research
  • Resource management
  • Rheumatic fever
  • Rheumatic Fever - diagnosis
  • Rheumatic heart disease
  • Rheumatic Heart Disease - diagnosis
  • Rheumatic Heart Disease - epidemiology
  • Rheumatic Heart Disease - physiopathology
  • Rheumatic Heart Disease - prevention & control
  • Risk factors
  • Seminars
  • Streptococcal infections
  • Young adults
ispartof: The Lancet (British edition), 2012, Vol.379 (9819), p.953-964
description: Summary Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250 000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever—the precursor to rheumatic heart disease—can affect different organs and lead to irreversible valve damage and heart failure. Although penicillin is effective in the prevention of the disease, treatment of advanced stages uses up a vast amount of resources, which makes disease management especially challenging in emerging nations. Guidelines have therefore emphasised antibiotic prophylaxis against recurrent episodes of acute rheumatic fever, which seems feasible and cost effective. Early detection and targeted treatment might be possible if populations at risk for rheumatic heart disease in endemic areas are screened. In this setting, active surveillance with echocardiography-based screening might become very important.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionSummary Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250 000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever—the precursor to rheumatic heart disease—can affect different organs and lead to irreversible valve damage and heart failure. Although penicillin is effective in the prevention of the disease, treatment of advanced stages uses up a vast amount of resources, which makes disease management especially challenging in emerging nations. Guidelines have therefore emphasised antibiotic prophylaxis against recurrent episodes of acute rheumatic fever, which seems feasible and cost effective. Early detection and targeted treatment might be possible if populations at risk for rheumatic heart disease in endemic areas are screened. In this setting, active surveillance with echocardiography-based screening might become very important.
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subjectAbridged Index Medicus ; Age ; Antibiotics ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Child ; Complications and side effects ; Coronary artery disease ; Damage prevention ; Developing countries ; Disease control ; Disease prevention ; Echocardiography ; Epidemiology ; Fever ; General aspects ; Health aspects ; Health risks ; Heart ; Heart diseases ; Humans ; Internal Medicine ; LDCs ; Medical sciences ; Medical treatment ; Morbidity ; Mortality ; Organs ; Penicillin ; Prevention ; Prophylaxis ; Research ; Resource management ; Rheumatic fever ; Rheumatic Fever - diagnosis ; Rheumatic heart disease ; Rheumatic Heart Disease - diagnosis ; Rheumatic Heart Disease - epidemiology ; Rheumatic Heart Disease - physiopathology ; Rheumatic Heart Disease - prevention & control ; Risk factors ; Seminars ; Streptococcal infections ; Young adults
ispartofThe Lancet (British edition), 2012, Vol.379 (9819), p.953-964
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descriptionSummary Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250 000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever—the precursor to rheumatic heart disease—can affect different organs and lead to irreversible valve damage and heart failure. Although penicillin is effective in the prevention of the disease, treatment of advanced stages uses up a vast amount of resources, which makes disease management especially challenging in emerging nations. Guidelines have therefore emphasised antibiotic prophylaxis against recurrent episodes of acute rheumatic fever, which seems feasible and cost effective. Early detection and targeted treatment might be possible if populations at risk for rheumatic heart disease in endemic areas are screened. In this setting, active surveillance with echocardiography-based screening might become very important.
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38Rheumatic Heart Disease - diagnosis
39Rheumatic Heart Disease - epidemiology
40Rheumatic Heart Disease - physiopathology
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42Risk factors
43Seminars
44Streptococcal infections
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abstractSummary Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250 000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever—the precursor to rheumatic heart disease—can affect different organs and lead to irreversible valve damage and heart failure. Although penicillin is effective in the prevention of the disease, treatment of advanced stages uses up a vast amount of resources, which makes disease management especially challenging in emerging nations. Guidelines have therefore emphasised antibiotic prophylaxis against recurrent episodes of acute rheumatic fever, which seems feasible and cost effective. Early detection and targeted treatment might be possible if populations at risk for rheumatic heart disease in endemic areas are screened. In this setting, active surveillance with echocardiography-based screening might become very important.
copKidlington
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pmid22405798
doi10.1016/S0140-6736(11)61171-9