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Blockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT

Abstract Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blo... Full description

Journal Title: Cancer letters 2011, Vol.318 (2), p.221-225
Main Author: Lee, Jungwhoi
Other Authors: Ku, Taeyun , Yu, Hana , Chong, Kyuha , Ryu, Seung-Wook , Choi, Kyungsun , Choi, Chulhee
Format: Electronic Article Electronic Article
Language: English
Subjects:
AKT
FAK
R&D
RNA
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/22182449
Zum Text:
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recordid: cdi_proquest_miscellaneous_928366150
title: Blockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
format: Article
creator:
  • Lee, Jungwhoi
  • Ku, Taeyun
  • Yu, Hana
  • Chong, Kyuha
  • Ryu, Seung-Wook
  • Choi, Kyungsun
  • Choi, Chulhee
subjects:
  • AKT
  • Angiogenesis
  • Animals
  • Apoptosis
  • Astrocytoma - enzymology
  • Astrocytoma - metabolism
  • Astrocytoma - pathology
  • Autocrine signaling
  • Base Sequence
  • Cancer
  • Cell culture
  • Cell Line, Tumor
  • Endothelial growth factors
  • Endothelium
  • FAK
  • Fibrosarcoma - enzymology
  • Fibrosarcoma - metabolism
  • Fibrosarcoma - pathology
  • Focal Adhesion Protein-Tyrosine Kinases - metabolism
  • Growth
  • Hematology, Oncology and Palliative Medicine
  • Hypoxia
  • Kinases
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Monosaccharides
  • Protein Kinase Inhibitors - pharmacology
  • Proto-Oncogene Proteins c-akt - metabolism
  • R&D
  • Research & development
  • RNA
  • RNA Interference
  • Sarcoma
  • Signal transduction
  • Signal Transduction - drug effects
  • Sugars
  • Tumors
  • Tyrosine
  • Variance analysis
  • Vascular endothelial growth factor
  • Vascular Endothelial Growth Factor A - antagonists & inhibitors
  • Vascular Endothelial Growth Factor A - genetics
  • VEGF
ispartof: Cancer letters, 2011, Vol.318 (2), p.221-225
description: Abstract Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blockade of VEGF-A using the doxycycline-inducible VEGF-A RNA interference system showed a significant anti-tumor effect in a murine HT-1080-xenograft model. Anti-tumor effect through the blockade of VEGF signaling was mediated by FAK and AKT pathway in vitro and in vivo . These results collectively indicate that VEGF-A and its receptors can act as key inducer of tumor growth as well as angiogenesis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleBlockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
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descriptionAbstract Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blockade of VEGF-A using the doxycycline-inducible VEGF-A RNA interference system showed a significant anti-tumor effect in a murine HT-1080-xenograft model. Anti-tumor effect through the blockade of VEGF signaling was mediated by FAK and AKT pathway in vitro and in vivo . These results collectively indicate that VEGF-A and its receptors can act as key inducer of tumor growth as well as angiogenesis.
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subjectAKT ; Angiogenesis ; Animals ; Apoptosis ; Astrocytoma - enzymology ; Astrocytoma - metabolism ; Astrocytoma - pathology ; Autocrine signaling ; Base Sequence ; Cancer ; Cell culture ; Cell Line, Tumor ; Endothelial growth factors ; Endothelium ; FAK ; Fibrosarcoma - enzymology ; Fibrosarcoma - metabolism ; Fibrosarcoma - pathology ; Focal Adhesion Protein-Tyrosine Kinases - metabolism ; Growth ; Hematology, Oncology and Palliative Medicine ; Hypoxia ; Kinases ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Monosaccharides ; Protein Kinase Inhibitors - pharmacology ; Proto-Oncogene Proteins c-akt - metabolism ; R&D ; Research & development ; RNA ; RNA Interference ; Sarcoma ; Signal transduction ; Signal Transduction - drug effects ; Sugars ; Tumors ; Tyrosine ; Variance analysis ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - antagonists & inhibitors ; Vascular Endothelial Growth Factor A - genetics ; VEGF
ispartofCancer letters, 2011, Vol.318 (2), p.221-225
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descriptionAbstract Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blockade of VEGF-A using the doxycycline-inducible VEGF-A RNA interference system showed a significant anti-tumor effect in a murine HT-1080-xenograft model. Anti-tumor effect through the blockade of VEGF signaling was mediated by FAK and AKT pathway in vitro and in vivo . These results collectively indicate that VEGF-A and its receptors can act as key inducer of tumor growth as well as angiogenesis.
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38Tyrosine
39Variance analysis
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titleBlockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
authorLee, Jungwhoi ; Ku, Taeyun ; Yu, Hana ; Chong, Kyuha ; Ryu, Seung-Wook ; Choi, Kyungsun ; Choi, Chulhee
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43VEGF
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atitleBlockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
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abstractAbstract Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blockade of VEGF-A using the doxycycline-inducible VEGF-A RNA interference system showed a significant anti-tumor effect in a murine HT-1080-xenograft model. Anti-tumor effect through the blockade of VEGF signaling was mediated by FAK and AKT pathway in vitro and in vivo . These results collectively indicate that VEGF-A and its receptors can act as key inducer of tumor growth as well as angiogenesis.
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pubElsevier Ireland Ltd
pmid22182449
doi10.1016/j.canlet.2011.12.014