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Comparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study

It has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2012-03, Vol.59 (3), p.580-586
Main Author: Muramatsu, Takashi
Other Authors: Matsushita, Kunihiro , Yamashita, Kentaro , Kondo, Takahisa , Maeda, Kengo , Shintani, Satoshi , Ichimiya, Satoshi , Ohno, Miyoshi , Sone, Takahito , Ikeda, Nobuo , Watarai, Masato , Murohara, Toyoaki
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: American Heart Association, Inc
ID: ISSN: 0194-911X
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title: Comparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study
format: Article
creator:
  • Muramatsu, Takashi
  • Matsushita, Kunihiro
  • Yamashita, Kentaro
  • Kondo, Takahisa
  • Maeda, Kengo
  • Shintani, Satoshi
  • Ichimiya, Satoshi
  • Ohno, Miyoshi
  • Sone, Takahito
  • Ikeda, Nobuo
  • Watarai, Masato
  • Murohara, Toyoaki
subjects:
  • Amlodipine - therapeutic use
  • Antihypertensive agents
  • Antihypertensive Agents - therapeutic use
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Blood Glucose - metabolism
  • Blood Pressure - drug effects
  • Cardiology. Vascular system
  • Cardiovascular system
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - epidemiology
  • Female
  • Follow-Up Studies
  • Glucose Intolerance
  • Glycated Hemoglobin A - metabolism
  • Humans
  • Hypertension - complications
  • Hypertension - drug therapy
  • Hypertension - epidemiology
  • Japan - epidemiology
  • Male
  • Medical sciences
  • Middle Aged
  • Morbidity - trends
  • Pharmacology. Drug treatments
  • Prospective Studies
  • Risk Factors
  • Survival Rate - trends
  • Tetrazoles - therapeutic use
  • Valine - analogs & derivatives
  • Valine - therapeutic use
  • Valsartan
ispartof: Hypertension (Dallas, Tex. 1979), 2012-03, Vol.59 (3), p.580-586
description: It has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients with type 2 diabetes mellitus or impaired glucose tolerance. A total of 1150 patients (women34%; mean age63 years; diabetes mellitus82%) were randomly assigned to receive either valsartan- or amlodipine-based antihypertensive treatment. Primary outcome was a composite of acute myocardial infarction, stroke, coronary revascularization, admission attributed to heart failure, or sudden cardiac death. Blood pressure was 145/82 and 144/81 mm Hg, and glycosylated hemoglobin was 7.0% and 6.9% at baseline in the valsartan group and the amlodipine group, respectively. Both of them were equally controlled between the 2 groups during the study. The median follow-up period was 3.2 years, and primary outcome had occurred in 54 patients in the valsartan group and 56 in the amlodipine group (hazard ratio0.97 [95% CI0.66–1.40]; P=0.85). Patients in the valsartan group had a significantly lower incidence of heart failure than in the amlodipine group (hazard ratio0.20 [95% CI0.06–0.69]; P=0.01). Other components and all-cause mortality were not significantly different between the 2 groups. Composite cardiovascular outcomes were comparable between the valsartan- and amlodipine-based treatments in Japanese hypertensive patients with glucose intolerance. Admission because of heart failure was significantly less in the valsartan group.
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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titleComparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study
creatorMuramatsu, Takashi ; Matsushita, Kunihiro ; Yamashita, Kentaro ; Kondo, Takahisa ; Maeda, Kengo ; Shintani, Satoshi ; Ichimiya, Satoshi ; Ohno, Miyoshi ; Sone, Takahito ; Ikeda, Nobuo ; Watarai, Masato ; Murohara, Toyoaki
creatorcontribMuramatsu, Takashi ; Matsushita, Kunihiro ; Yamashita, Kentaro ; Kondo, Takahisa ; Maeda, Kengo ; Shintani, Satoshi ; Ichimiya, Satoshi ; Ohno, Miyoshi ; Sone, Takahito ; Ikeda, Nobuo ; Watarai, Masato ; Murohara, Toyoaki ; NAGOYA HEART Study Investigators ; for the NAGOYA HEART Study Investigators
descriptionIt has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients with type 2 diabetes mellitus or impaired glucose tolerance. A total of 1150 patients (women34%; mean age63 years; diabetes mellitus82%) were randomly assigned to receive either valsartan- or amlodipine-based antihypertensive treatment. Primary outcome was a composite of acute myocardial infarction, stroke, coronary revascularization, admission attributed to heart failure, or sudden cardiac death. Blood pressure was 145/82 and 144/81 mm Hg, and glycosylated hemoglobin was 7.0% and 6.9% at baseline in the valsartan group and the amlodipine group, respectively. Both of them were equally controlled between the 2 groups during the study. The median follow-up period was 3.2 years, and primary outcome had occurred in 54 patients in the valsartan group and 56 in the amlodipine group (hazard ratio0.97 [95% CI0.66–1.40]; P=0.85). Patients in the valsartan group had a significantly lower incidence of heart failure than in the amlodipine group (hazard ratio0.20 [95% CI0.06–0.69]; P=0.01). Other components and all-cause mortality were not significantly different between the 2 groups. Composite cardiovascular outcomes were comparable between the valsartan- and amlodipine-based treatments in Japanese hypertensive patients with glucose intolerance. Admission because of heart failure was significantly less in the valsartan group.
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subjectAmlodipine - therapeutic use ; Antihypertensive agents ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - metabolism ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Cardiovascular system ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Follow-Up Studies ; Glucose Intolerance ; Glycated Hemoglobin A - metabolism ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - epidemiology ; Japan - epidemiology ; Male ; Medical sciences ; Middle Aged ; Morbidity - trends ; Pharmacology. Drug treatments ; Prospective Studies ; Risk Factors ; Survival Rate - trends ; Tetrazoles - therapeutic use ; Valine - analogs & derivatives ; Valine - therapeutic use ; Valsartan
ispartofHypertension (Dallas, Tex. 1979), 2012-03, Vol.59 (3), p.580-586
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0Muramatsu, Takashi
1Matsushita, Kunihiro
2Yamashita, Kentaro
3Kondo, Takahisa
4Maeda, Kengo
5Shintani, Satoshi
6Ichimiya, Satoshi
7Ohno, Miyoshi
8Sone, Takahito
9Ikeda, Nobuo
10Watarai, Masato
11Murohara, Toyoaki
12NAGOYA HEART Study Investigators
13for the NAGOYA HEART Study Investigators
title
0Comparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study
1Hypertension (Dallas, Tex. 1979)
addtitleHypertension
descriptionIt has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients with type 2 diabetes mellitus or impaired glucose tolerance. A total of 1150 patients (women34%; mean age63 years; diabetes mellitus82%) were randomly assigned to receive either valsartan- or amlodipine-based antihypertensive treatment. Primary outcome was a composite of acute myocardial infarction, stroke, coronary revascularization, admission attributed to heart failure, or sudden cardiac death. Blood pressure was 145/82 and 144/81 mm Hg, and glycosylated hemoglobin was 7.0% and 6.9% at baseline in the valsartan group and the amlodipine group, respectively. Both of them were equally controlled between the 2 groups during the study. The median follow-up period was 3.2 years, and primary outcome had occurred in 54 patients in the valsartan group and 56 in the amlodipine group (hazard ratio0.97 [95% CI0.66–1.40]; P=0.85). Patients in the valsartan group had a significantly lower incidence of heart failure than in the amlodipine group (hazard ratio0.20 [95% CI0.06–0.69]; P=0.01). Other components and all-cause mortality were not significantly different between the 2 groups. Composite cardiovascular outcomes were comparable between the valsartan- and amlodipine-based treatments in Japanese hypertensive patients with glucose intolerance. Admission because of heart failure was significantly less in the valsartan group.
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0Amlodipine - therapeutic use
1Antihypertensive agents
2Antihypertensive Agents - therapeutic use
3Arterial hypertension. Arterial hypotension
4Biological and medical sciences
5Blood and lymphatic vessels
6Blood Glucose - metabolism
7Blood Pressure - drug effects
8Cardiology. Vascular system
9Cardiovascular system
10Diabetes Mellitus, Type 2 - blood
11Diabetes Mellitus, Type 2 - complications
12Diabetes Mellitus, Type 2 - epidemiology
13Female
14Follow-Up Studies
15Glucose Intolerance
16Glycated Hemoglobin A - metabolism
17Humans
18Hypertension - complications
19Hypertension - drug therapy
20Hypertension - epidemiology
21Japan - epidemiology
22Male
23Medical sciences
24Middle Aged
25Morbidity - trends
26Pharmacology. Drug treatments
27Prospective Studies
28Risk Factors
29Survival Rate - trends
30Tetrazoles - therapeutic use
31Valine - analogs & derivatives
32Valine - therapeutic use
33Valsartan
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3Kondo, Takahisa
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5Shintani, Satoshi
6Ichimiya, Satoshi
7Ohno, Miyoshi
8Sone, Takahito
9Ikeda, Nobuo
10Watarai, Masato
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titleComparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study
authorMuramatsu, Takashi ; Matsushita, Kunihiro ; Yamashita, Kentaro ; Kondo, Takahisa ; Maeda, Kengo ; Shintani, Satoshi ; Ichimiya, Satoshi ; Ohno, Miyoshi ; Sone, Takahito ; Ikeda, Nobuo ; Watarai, Masato ; Murohara, Toyoaki
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0Amlodipine - therapeutic use
1Antihypertensive agents
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3Arterial hypertension. Arterial hypotension
4Biological and medical sciences
5Blood and lymphatic vessels
6Blood Glucose - metabolism
7Blood Pressure - drug effects
8Cardiology. Vascular system
9Cardiovascular system
10Diabetes Mellitus, Type 2 - blood
11Diabetes Mellitus, Type 2 - complications
12Diabetes Mellitus, Type 2 - epidemiology
13Female
14Follow-Up Studies
15Glucose Intolerance
16Glycated Hemoglobin A - metabolism
17Humans
18Hypertension - complications
19Hypertension - drug therapy
20Hypertension - epidemiology
21Japan - epidemiology
22Male
23Medical sciences
24Middle Aged
25Morbidity - trends
26Pharmacology. Drug treatments
27Prospective Studies
28Risk Factors
29Survival Rate - trends
30Tetrazoles - therapeutic use
31Valine - analogs & derivatives
32Valine - therapeutic use
33Valsartan
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1Matsushita, Kunihiro
2Yamashita, Kentaro
3Kondo, Takahisa
4Maeda, Kengo
5Shintani, Satoshi
6Ichimiya, Satoshi
7Ohno, Miyoshi
8Sone, Takahito
9Ikeda, Nobuo
10Watarai, Masato
11Murohara, Toyoaki
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7Ohno, Miyoshi
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jtitleHypertension (Dallas, Tex. 1979)
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date2012-03
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epage586
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abstractIt has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients with type 2 diabetes mellitus or impaired glucose tolerance. A total of 1150 patients (women34%; mean age63 years; diabetes mellitus82%) were randomly assigned to receive either valsartan- or amlodipine-based antihypertensive treatment. Primary outcome was a composite of acute myocardial infarction, stroke, coronary revascularization, admission attributed to heart failure, or sudden cardiac death. Blood pressure was 145/82 and 144/81 mm Hg, and glycosylated hemoglobin was 7.0% and 6.9% at baseline in the valsartan group and the amlodipine group, respectively. Both of them were equally controlled between the 2 groups during the study. The median follow-up period was 3.2 years, and primary outcome had occurred in 54 patients in the valsartan group and 56 in the amlodipine group (hazard ratio0.97 [95% CI0.66–1.40]; P=0.85). Patients in the valsartan group had a significantly lower incidence of heart failure than in the amlodipine group (hazard ratio0.20 [95% CI0.06–0.69]; P=0.01). Other components and all-cause mortality were not significantly different between the 2 groups. Composite cardiovascular outcomes were comparable between the valsartan- and amlodipine-based treatments in Japanese hypertensive patients with glucose intolerance. Admission because of heart failure was significantly less in the valsartan group.
copHagerstown, MD
pubAmerican Heart Association, Inc
pmid22232134
doi10.1161/HYPERTENSIONAHA.111.184226
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