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Oxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in Trotters

Strenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces pr... Full description

Journal Title: European journal of applied physiology 2005-12, Vol.95 (5-6), p.550-556
Main Author: Kinnunen, Susanna
Other Authors: Hyyppä, Seppo , Lehmuskero, Arja , Oksala, Niku , Mäenpää, Pekka , Hänninen, Osmo , Atalay, Mustafa
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Germany: Springer
ID: ISSN: 1439-6319
Link: https://www.ncbi.nlm.nih.gov/pubmed/16136323
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recordid: cdi_proquest_miscellaneous_954592670
title: Oxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in Trotters
format: Article
creator:
  • Kinnunen, Susanna
  • Hyyppä, Seppo
  • Lehmuskero, Arja
  • Oksala, Niku
  • Mäenpää, Pekka
  • Hänninen, Osmo
  • Atalay, Mustafa
subjects:
  • Animals
  • Antioxidants
  • Antioxidants - metabolism
  • Glutathione - metabolism
  • Harness racehorses
  • Horses
  • Horses - metabolism
  • Lipid Peroxides - blood
  • Nutrition
  • Oxidative stress
  • Oxidative Stress - physiology
  • Physical Conditioning, Animal - physiology
  • Physiological aspects
  • Reactive Oxygen Species - metabolism
  • Vitamin E - blood
ispartof: European journal of applied physiology, 2005-12, Vol.95 (5-6), p.550-556
description: Strenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces protein oxidation in trotters. The aim of this study was to measure the antioxidative capacity of the horse in relation to different antioxidant components and oxidative stress markers after a single bout of moderate exercise to elucidate the mechanisms of antioxidant protection in horses. Eight clinically normal and regularly trained standard-bred trotters were treadmill-exercised for 53 min at moderate intensity. Blood samples were collected prior to and immediately after exercise and at 4 and 24 h of recovery. Muscle biopsies from the middle gluteal muscle were taken before exercise and after 4 h of recovery. Acute induction of oxygen radical absorbance capacity (ORAC) did not prevent exercise-induced oxidative stress, which was demonstrated by increased lipid hydroperoxides (LPO). Pre-exercise ORAC levels were, however, a determinant of total glutathione content of the blood after 4 and 24 h of recovery. Furthermore, baseline ORAC level correlated negatively with 4-h recovery LPO levels. Our results imply that horses are susceptible to oxidative stress, but a stronger antioxidant capacity may improve coping with exercise-induced oxidative stress.
language: eng
source:
identifier: ISSN: 1439-6319
fulltext: no_fulltext
issn:
  • 1439-6319
  • 1439-6327
url: Link


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titleOxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in Trotters
creatorKinnunen, Susanna ; Hyyppä, Seppo ; Lehmuskero, Arja ; Oksala, Niku ; Mäenpää, Pekka ; Hänninen, Osmo ; Atalay, Mustafa
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descriptionStrenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces protein oxidation in trotters. The aim of this study was to measure the antioxidative capacity of the horse in relation to different antioxidant components and oxidative stress markers after a single bout of moderate exercise to elucidate the mechanisms of antioxidant protection in horses. Eight clinically normal and regularly trained standard-bred trotters were treadmill-exercised for 53 min at moderate intensity. Blood samples were collected prior to and immediately after exercise and at 4 and 24 h of recovery. Muscle biopsies from the middle gluteal muscle were taken before exercise and after 4 h of recovery. Acute induction of oxygen radical absorbance capacity (ORAC) did not prevent exercise-induced oxidative stress, which was demonstrated by increased lipid hydroperoxides (LPO). Pre-exercise ORAC levels were, however, a determinant of total glutathione content of the blood after 4 and 24 h of recovery. Furthermore, baseline ORAC level correlated negatively with 4-h recovery LPO levels. Our results imply that horses are susceptible to oxidative stress, but a stronger antioxidant capacity may improve coping with exercise-induced oxidative stress.
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subjectAnimals ; Antioxidants ; Antioxidants - metabolism ; Glutathione - metabolism ; Harness racehorses ; Horses ; Horses - metabolism ; Lipid Peroxides - blood ; Nutrition ; Oxidative stress ; Oxidative Stress - physiology ; Physical Conditioning, Animal - physiology ; Physiological aspects ; Reactive Oxygen Species - metabolism ; Vitamin E - blood
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descriptionStrenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces protein oxidation in trotters. The aim of this study was to measure the antioxidative capacity of the horse in relation to different antioxidant components and oxidative stress markers after a single bout of moderate exercise to elucidate the mechanisms of antioxidant protection in horses. Eight clinically normal and regularly trained standard-bred trotters were treadmill-exercised for 53 min at moderate intensity. Blood samples were collected prior to and immediately after exercise and at 4 and 24 h of recovery. Muscle biopsies from the middle gluteal muscle were taken before exercise and after 4 h of recovery. Acute induction of oxygen radical absorbance capacity (ORAC) did not prevent exercise-induced oxidative stress, which was demonstrated by increased lipid hydroperoxides (LPO). Pre-exercise ORAC levels were, however, a determinant of total glutathione content of the blood after 4 and 24 h of recovery. Furthermore, baseline ORAC level correlated negatively with 4-h recovery LPO levels. Our results imply that horses are susceptible to oxidative stress, but a stronger antioxidant capacity may improve coping with exercise-induced oxidative stress.
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titleOxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in Trotters
authorKinnunen, Susanna ; Hyyppä, Seppo ; Lehmuskero, Arja ; Oksala, Niku ; Mäenpää, Pekka ; Hänninen, Osmo ; Atalay, Mustafa
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atitleOxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in Trotters
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abstractStrenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces protein oxidation in trotters. The aim of this study was to measure the antioxidative capacity of the horse in relation to different antioxidant components and oxidative stress markers after a single bout of moderate exercise to elucidate the mechanisms of antioxidant protection in horses. Eight clinically normal and regularly trained standard-bred trotters were treadmill-exercised for 53 min at moderate intensity. Blood samples were collected prior to and immediately after exercise and at 4 and 24 h of recovery. Muscle biopsies from the middle gluteal muscle were taken before exercise and after 4 h of recovery. Acute induction of oxygen radical absorbance capacity (ORAC) did not prevent exercise-induced oxidative stress, which was demonstrated by increased lipid hydroperoxides (LPO). Pre-exercise ORAC levels were, however, a determinant of total glutathione content of the blood after 4 and 24 h of recovery. Furthermore, baseline ORAC level correlated negatively with 4-h recovery LPO levels. Our results imply that horses are susceptible to oxidative stress, but a stronger antioxidant capacity may improve coping with exercise-induced oxidative stress.
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