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Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics

The aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic intera... Full description

Journal Title: Phytomedicine (Stuttgart) 2012-03-15, Vol.19 (5), p.464-471
Main Author: Fadli, Mariam
Other Authors: Saad, Asmaa , Sayadi, Sami , Chevalier, Jacqueline , Mezrioui, Nour-Eddine , Pagès, Jean-Marie , Hassani, Lahcen
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/22257599
Zum Text:
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title: Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics
format: Article
creator:
  • Fadli, Mariam
  • Saad, Asmaa
  • Sayadi, Sami
  • Chevalier, Jacqueline
  • Mezrioui, Nour-Eddine
  • Pagès, Jean-Marie
  • Hassani, Lahcen
subjects:
  • Anti-Bacterial Agents - chemistry
  • Anti-Bacterial Agents - pharmacology
  • Antibacterial activity
  • Antibiotics
  • Antimicrobial agents
  • Bacterial constituent's release
  • Bacterial infections
  • Bacterial Infections - drug therapy
  • Bacterial Infections - microbiology
  • Care and treatment
  • Carvacrol
  • Cefixime
  • Ciprofloxacin
  • Ciprofloxacin - pharmacology
  • Cross Infection - drug therapy
  • Cross Infection - microbiology
  • Drug Synergism
  • Essences and essential oils
  • Essential oil
  • Essential oils
  • Gentamicin
  • Gram-negative bacteria
  • Gram-Negative Bacteria - drug effects
  • Gram-Negative Bacteria - growth & development
  • Gram-positive bacteria
  • Gram-Positive Bacteria - drug effects
  • Gram-Positive Bacteria - growth & development
  • Health aspects
  • Humans
  • Microbial Sensitivity Tests
  • Monoterpenes - pharmacology
  • Nosocomial infection
  • Oils, Volatile - chemistry
  • Oils, Volatile - pharmacology
  • Plant Components, Aerial - chemistry
  • Plant Oils - chemistry
  • Plant Oils - pharmacology
  • Pristinamycin
  • Pseudomonas aeruginosa
  • Pseudomonas aeruginosa - drug effects
  • Pseudomonas aeruginosa - growth & development
  • Side effects
  • Synergy
  • Therapeutic applications
  • Thymus
  • Thymus broussonetii
  • Thymus maroccanus
  • Thymus Plant - chemistry
ispartof: Phytomedicine (Stuttgart), 2012-03-15, Vol.19 (5), p.464-471
description: The aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T. Broussonetii EOs were determined by the checkerboard test. Serial dilutions of two antimicrobial agents were mixed together so that each row (and column) contained a fixed amount of the first agent and increasing amounts of the second one. The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa. In parallel with the increase of cellular killing, the release of 260nm-absorbing materials from bacterial cells, treated with EOs, increased in response to oil concentration. Out of 80 combinations tested between EOs and antibiotics, 71% showed total synergism, 20% had partial synergistic interaction and 9% showed no effect. Combination with carvacrol, the major constituent of T. maroccanus and T. broussonetii, showed also an interesting synergistic effect in combination with ciprofloxacin. The effect on Gram-positive bacteria was more important than on Gram-negative bacteria. These findings are very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost. However, further investigations are needed to assess the potential for therapeutic application.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleAntibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics
sourceAlma/SFX Local Collection
creatorFadli, Mariam ; Saad, Asmaa ; Sayadi, Sami ; Chevalier, Jacqueline ; Mezrioui, Nour-Eddine ; Pagès, Jean-Marie ; Hassani, Lahcen
creatorcontribFadli, Mariam ; Saad, Asmaa ; Sayadi, Sami ; Chevalier, Jacqueline ; Mezrioui, Nour-Eddine ; Pagès, Jean-Marie ; Hassani, Lahcen
descriptionThe aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T. Broussonetii EOs were determined by the checkerboard test. Serial dilutions of two antimicrobial agents were mixed together so that each row (and column) contained a fixed amount of the first agent and increasing amounts of the second one. The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa. In parallel with the increase of cellular killing, the release of 260nm-absorbing materials from bacterial cells, treated with EOs, increased in response to oil concentration. Out of 80 combinations tested between EOs and antibiotics, 71% showed total synergism, 20% had partial synergistic interaction and 9% showed no effect. Combination with carvacrol, the major constituent of T. maroccanus and T. broussonetii, showed also an interesting synergistic effect in combination with ciprofloxacin. The effect on Gram-positive bacteria was more important than on Gram-negative bacteria. These findings are very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost. However, further investigations are needed to assess the potential for therapeutic application.
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languageeng
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subjectAnti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antibiotics ; Antimicrobial agents ; Bacterial constituent's release ; Bacterial infections ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; Care and treatment ; Carvacrol ; Cefixime ; Ciprofloxacin ; Ciprofloxacin - pharmacology ; Cross Infection - drug therapy ; Cross Infection - microbiology ; Drug Synergism ; Essences and essential oils ; Essential oil ; Essential oils ; Gentamicin ; Gram-negative bacteria ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - growth & development ; Gram-positive bacteria ; Gram-Positive Bacteria - drug effects ; Gram-Positive Bacteria - growth & development ; Health aspects ; Humans ; Microbial Sensitivity Tests ; Monoterpenes - pharmacology ; Nosocomial infection ; Oils, Volatile - chemistry ; Oils, Volatile - pharmacology ; Plant Components, Aerial - chemistry ; Plant Oils - chemistry ; Plant Oils - pharmacology ; Pristinamycin ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - growth & development ; Side effects ; Synergy ; Therapeutic applications ; Thymus ; Thymus broussonetii ; Thymus maroccanus ; Thymus Plant - chemistry
ispartofPhytomedicine (Stuttgart), 2012-03-15, Vol.19 (5), p.464-471
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2Sayadi, Sami
3Chevalier, Jacqueline
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5Pagès, Jean-Marie
6Hassani, Lahcen
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descriptionThe aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T. Broussonetii EOs were determined by the checkerboard test. Serial dilutions of two antimicrobial agents were mixed together so that each row (and column) contained a fixed amount of the first agent and increasing amounts of the second one. The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa. In parallel with the increase of cellular killing, the release of 260nm-absorbing materials from bacterial cells, treated with EOs, increased in response to oil concentration. Out of 80 combinations tested between EOs and antibiotics, 71% showed total synergism, 20% had partial synergistic interaction and 9% showed no effect. Combination with carvacrol, the major constituent of T. maroccanus and T. broussonetii, showed also an interesting synergistic effect in combination with ciprofloxacin. The effect on Gram-positive bacteria was more important than on Gram-negative bacteria. These findings are very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost. However, further investigations are needed to assess the potential for therapeutic application.
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0Anti-Bacterial Agents - chemistry
1Anti-Bacterial Agents - pharmacology
2Antibacterial activity
3Antibiotics
4Antimicrobial agents
5Bacterial constituent's release
6Bacterial infections
7Bacterial Infections - drug therapy
8Bacterial Infections - microbiology
9Care and treatment
10Carvacrol
11Cefixime
12Ciprofloxacin
13Ciprofloxacin - pharmacology
14Cross Infection - drug therapy
15Cross Infection - microbiology
16Drug Synergism
17Essences and essential oils
18Essential oil
19Essential oils
20Gentamicin
21Gram-negative bacteria
22Gram-Negative Bacteria - drug effects
23Gram-Negative Bacteria - growth & development
24Gram-positive bacteria
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26Gram-Positive Bacteria - growth & development
27Health aspects
28Humans
29Microbial Sensitivity Tests
30Monoterpenes - pharmacology
31Nosocomial infection
32Oils, Volatile - chemistry
33Oils, Volatile - pharmacology
34Plant Components, Aerial - chemistry
35Plant Oils - chemistry
36Plant Oils - pharmacology
37Pristinamycin
38Pseudomonas aeruginosa
39Pseudomonas aeruginosa - drug effects
40Pseudomonas aeruginosa - growth & development
41Side effects
42Synergy
43Therapeutic applications
44Thymus
45Thymus broussonetii
46Thymus maroccanus
47Thymus Plant - chemistry
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titleAntibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics
authorFadli, Mariam ; Saad, Asmaa ; Sayadi, Sami ; Chevalier, Jacqueline ; Mezrioui, Nour-Eddine ; Pagès, Jean-Marie ; Hassani, Lahcen
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jtitlePhytomedicine (Stuttgart)
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date2012-03-15
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volume19
issue5
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issn0944-7113
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abstractThe aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T. Broussonetii EOs were determined by the checkerboard test. Serial dilutions of two antimicrobial agents were mixed together so that each row (and column) contained a fixed amount of the first agent and increasing amounts of the second one. The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa. In parallel with the increase of cellular killing, the release of 260nm-absorbing materials from bacterial cells, treated with EOs, increased in response to oil concentration. Out of 80 combinations tested between EOs and antibiotics, 71% showed total synergism, 20% had partial synergistic interaction and 9% showed no effect. Combination with carvacrol, the major constituent of T. maroccanus and T. broussonetii, showed also an interesting synergistic effect in combination with ciprofloxacin. The effect on Gram-positive bacteria was more important than on Gram-negative bacteria. These findings are very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost. However, further investigations are needed to assess the potential for therapeutic application.
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doi10.1016/j.phymed.2011.12.003
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