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LIPOPROTEIN RECEPTORS IN THE NERVOUS SYSTEM

The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin... Full description

Journal Title: Annual review of biochemistry 2002-07, Vol.71 (1), p.405-434
Main Author: Herz, Joachim
Other Authors: Bock, Hans H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Palo Alto, CA 94303-0139: Annual Reviews
ID: ISSN: 0066-4154
Link: https://www.ncbi.nlm.nih.gov/pubmed/12045102
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recordid: cdi_pubmed_primary_12045102
title: LIPOPROTEIN RECEPTORS IN THE NERVOUS SYSTEM
format: Article
creator:
  • Herz, Joachim
  • Bock, Hans H
subjects:
  • Animals
  • apolipoprotein E
  • Apolipoproteins E - genetics
  • Apolipoproteins E - metabolism
  • Biochemistry
  • Brain - growth & development
  • Brain - physiology
  • Caveolae - metabolism
  • Cell Adhesion Molecules, Neuronal - metabolism
  • Central Nervous System - physiology
  • Cholesterol
  • Cholesterol - metabolism
  • Extracellular Matrix Proteins - metabolism
  • Hedgehog Proteins
  • Learning - physiology
  • Ligands
  • Ligands (Biochemistry)
  • Lipoproteins
  • Membrane Microdomains - metabolism
  • Multigene Family
  • Nerve Tissue Proteins
  • Nervous system
  • neurotransmission
  • Physiological aspects
  • Protein Transport - physiology
  • Proteins
  • Proto-Oncogene Proteins - metabolism
  • Receptors
  • Receptors, LDL - chemistry
  • Receptors, LDL - genetics
  • Receptors, LDL - metabolism
  • Receptors, N-Methyl-D-Aspartate - metabolism
  • Reelin
  • Serine Endopeptidases
  • Signal Transduction - physiology
  • signaling
  • Trans-Activators - metabolism
  • Wnt Proteins
  • Zebrafish Proteins
ispartof: Annual review of biochemistry, 2002-07, Vol.71 (1), p.405-434
description: The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4154
fulltext: fulltext
issn:
  • 0066-4154
  • 1545-4509
url: Link


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descriptionThe low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.
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subjectAnimals ; apolipoprotein E ; Apolipoproteins E - genetics ; Apolipoproteins E - metabolism ; Biochemistry ; Brain - growth & development ; Brain - physiology ; Caveolae - metabolism ; Cell Adhesion Molecules, Neuronal - metabolism ; Central Nervous System - physiology ; Cholesterol ; Cholesterol - metabolism ; Extracellular Matrix Proteins - metabolism ; Hedgehog Proteins ; Learning - physiology ; Ligands ; Ligands (Biochemistry) ; Lipoproteins ; Membrane Microdomains - metabolism ; Multigene Family ; Nerve Tissue Proteins ; Nervous system ; neurotransmission ; Physiological aspects ; Protein Transport - physiology ; Proteins ; Proto-Oncogene Proteins - metabolism ; Receptors ; Receptors, LDL - chemistry ; Receptors, LDL - genetics ; Receptors, LDL - metabolism ; Receptors, N-Methyl-D-Aspartate - metabolism ; Reelin ; Serine Endopeptidases ; Signal Transduction - physiology ; signaling ; Trans-Activators - metabolism ; Wnt Proteins ; Zebrafish Proteins
ispartofAnnual review of biochemistry, 2002-07, Vol.71 (1), p.405-434
rightsCopyright © 2002 by Annual Reviews. All rights reserved
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12Extracellular Matrix Proteins - metabolism
13Hedgehog Proteins
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32Reelin
33Serine Endopeptidases
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35signaling
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37Wnt Proteins
38Zebrafish Proteins
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26Proto-Oncogene Proteins - metabolism
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28Receptors, LDL - chemistry
29Receptors, LDL - genetics
30Receptors, LDL - metabolism
31Receptors, N-Methyl-D-Aspartate - metabolism
32Reelin
33Serine Endopeptidases
34Signal Transduction - physiology
35signaling
36Trans-Activators - metabolism
37Wnt Proteins
38Zebrafish Proteins
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abstractThe low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.
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pmid12045102
doi10.1146/annurev.biochem.71.110601.135342