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Insulin Sensitivity in Adults with Growth Hormone Deficiency and Effect of Growth Hormone Treatment

Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also ra... Full description

Journal Title: Hormone research 2006-02, Vol.64 (3), p.45-50
Main Author: Groop, Leif
Other Authors: Segerlantz, Mikael , Bramnert, Margareta
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland
ID: ISSN: 1663-2818
Zum Text:
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recordid: cdi_pubmed_primary_16439844
title: Insulin Sensitivity in Adults with Growth Hormone Deficiency and Effect of Growth Hormone Treatment
format: Article
creator:
  • Groop, Leif
  • Segerlantz, Mikael
  • Bramnert, Margareta
subjects:
  • Adenoma - complications
  • Adenoma - drug therapy
  • Adenoma - metabolism
  • Adult
  • adults
  • Clinical Medicine
  • Diabetes Mellitus - chemically induced
  • Diabetes Mellitus - etiology
  • Diabetes Mellitus - metabolism
  • Endocrinology and Diabetes
  • Endokrinologi och diabetes
  • Female
  • Glucose - metabolism
  • Glucose Intolerance - chemically induced
  • Glucose Intolerance - etiology
  • Glucose Intolerance - metabolism
  • growth hormone
  • growth hormone deficiency
  • Human Growth Hormone - adverse effects
  • Human Growth Hormone - deficiency
  • Human Growth Hormone - therapeutic use
  • Humans
  • Insulin Resistance
  • insulin sensitivity
  • Insulin Sensitivity: Clinical Impact
  • Klinisk medicin
  • Lipid Metabolism - drug effects
  • Male
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Oxidation-Reduction - drug effects
  • Pituitary Neoplasms - complications
  • Pituitary Neoplasms - drug therapy
  • Pituitary Neoplasms - metabolism
  • treatment
ispartof: Hormone research, 2006-02, Vol.64 (3), p.45-50
description: Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1663-2818
fulltext: fulltext
issn:
  • 1663-2818
  • 0301-0163
  • 1663-2826
  • 1423-0046
url: Link


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descriptionAdult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.
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languageeng
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subjectAdenoma - complications ; Adenoma - drug therapy ; Adenoma - metabolism ; Adult ; adults ; Clinical Medicine ; Diabetes Mellitus - chemically induced ; Diabetes Mellitus - etiology ; Diabetes Mellitus - metabolism ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; Female ; Glucose - metabolism ; Glucose Intolerance - chemically induced ; Glucose Intolerance - etiology ; Glucose Intolerance - metabolism ; growth hormone ; growth hormone deficiency ; Human Growth Hormone - adverse effects ; Human Growth Hormone - deficiency ; Human Growth Hormone - therapeutic use ; Humans ; Insulin Resistance ; insulin sensitivity ; Insulin Sensitivity: Clinical Impact ; Klinisk medicin ; Lipid Metabolism - drug effects ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Oxidation-Reduction - drug effects ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - drug therapy ; Pituitary Neoplasms - metabolism ; treatment
ispartofHormone research, 2006-02, Vol.64 (3), p.45-50
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descriptionAdult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.
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0Adenoma - complications
1Adenoma - drug therapy
2Adenoma - metabolism
3Adult
4adults
5Clinical Medicine
6Diabetes Mellitus - chemically induced
7Diabetes Mellitus - etiology
8Diabetes Mellitus - metabolism
9Endocrinology and Diabetes
10Endokrinologi och diabetes
11Female
12Glucose - metabolism
13Glucose Intolerance - chemically induced
14Glucose Intolerance - etiology
15Glucose Intolerance - metabolism
16growth hormone
17growth hormone deficiency
18Human Growth Hormone - adverse effects
19Human Growth Hormone - deficiency
20Human Growth Hormone - therapeutic use
21Humans
22Insulin Resistance
23insulin sensitivity
24Insulin Sensitivity: Clinical Impact
25Klinisk medicin
26Lipid Metabolism - drug effects
27Male
28Medical and Health Sciences
29Medicin och hälsovetenskap
30Oxidation-Reduction - drug effects
31Pituitary Neoplasms - complications
32Pituitary Neoplasms - drug therapy
33Pituitary Neoplasms - metabolism
34treatment
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5Clinical Medicine
6Diabetes Mellitus - chemically induced
7Diabetes Mellitus - etiology
8Diabetes Mellitus - metabolism
9Endocrinology and Diabetes
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13Glucose Intolerance - chemically induced
14Glucose Intolerance - etiology
15Glucose Intolerance - metabolism
16growth hormone
17growth hormone deficiency
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23insulin sensitivity
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28Medical and Health Sciences
29Medicin och hälsovetenskap
30Oxidation-Reduction - drug effects
31Pituitary Neoplasms - complications
32Pituitary Neoplasms - drug therapy
33Pituitary Neoplasms - metabolism
34treatment
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abstractAdult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.
copBasel, Switzerland
pmid16439844
doi10.1159/000089317
tpages6