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An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer

Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association b... Full description

Journal Title: Digestion 2007, Vol.74 (2), p.85-90
Main Author: Tang, Li Ping
Other Authors: Cho, Chi Hin , Hui, Wai Mo , Huang, Camy , Chu, Kent Man , Xia, Harry H.X , Lam, Shiu Kum , Rashid, Asif , Wong, Benjamin C.Y , Chan, Annie On On
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 0012-2823
Link: https://www.ncbi.nlm.nih.gov/pubmed/17139167
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title: An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
format: Article
creator:
  • Tang, Li Ping
  • Cho, Chi Hin
  • Hui, Wai Mo
  • Huang, Camy
  • Chu, Kent Man
  • Xia, Harry H.X
  • Lam, Shiu Kum
  • Rashid, Asif
  • Wong, Benjamin C.Y
  • Chan, Annie On On
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Apoptosis Regulatory Proteins - genetics
  • Cadherins - genetics
  • Calcium-Calmodulin-Dependent Protein Kinases - genetics
  • CpG Islands - genetics
  • Death-Associated Protein Kinases
  • DNA Methylation
  • DNA Modification Methylases
  • DNA Repair Enzymes
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genes, p16
  • Genes, Tumor Suppressor
  • Humans
  • Interleukin-6 - blood
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Original Paper
  • Prognosis
  • Promoter Regions, Genetic - genetics
  • Stomach Neoplasms - diagnosis
  • Stomach Neoplasms - mortality
  • Stomach Neoplasms - pathology
  • Tumor Suppressor Protein p14ARF - genetics
  • Tumor Suppressor Proteins
ispartof: Digestion, 2007, Vol.74 (2), p.85-90
description: Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0012-2823
fulltext: fulltext
issn:
  • 0012-2823
  • 1421-9867
url: Link


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titleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
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creatorTang, Li Ping ; Cho, Chi Hin ; Hui, Wai Mo ; Huang, Camy ; Chu, Kent Man ; Xia, Harry H.X ; Lam, Shiu Kum ; Rashid, Asif ; Wong, Benjamin C.Y ; Chan, Annie On On
creatorcontribTang, Li Ping ; Cho, Chi Hin ; Hui, Wai Mo ; Huang, Camy ; Chu, Kent Man ; Xia, Harry H.X ; Lam, Shiu Kum ; Rashid, Asif ; Wong, Benjamin C.Y ; Chan, Annie On On
descriptionBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
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subjectAdult ; Aged ; Aged, 80 and over ; Apoptosis Regulatory Proteins - genetics ; Cadherins - genetics ; Calcium-Calmodulin-Dependent Protein Kinases - genetics ; CpG Islands - genetics ; Death-Associated Protein Kinases ; DNA Methylation ; DNA Modification Methylases ; DNA Repair Enzymes ; Female ; Gene Expression Regulation, Neoplastic ; Genes, p16 ; Genes, Tumor Suppressor ; Humans ; Interleukin-6 - blood ; Male ; Middle Aged ; Neoplasm Staging ; Original Paper ; Prognosis ; Promoter Regions, Genetic - genetics ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Tumor Suppressor Protein p14ARF - genetics ; Tumor Suppressor Proteins
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8Wong, Benjamin C.Y
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descriptionBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
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22Promoter Regions, Genetic - genetics
23Stomach Neoplasms - diagnosis
24Stomach Neoplasms - mortality
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26Tumor Suppressor Protein p14ARF - genetics
27Tumor Suppressor Proteins
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titleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
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1Cho, Chi Hin
2Hui, Wai Mo
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5Xia, Harry H.X
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8Wong, Benjamin C.Y
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atitleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
jtitleDigestion
addtitleDigestion
date2007-02
risdate2007
volume74
issue2
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pages85-90
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eissn1421-9867
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abstractBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
copBasel, Switzerland
pubS. Karger AG
pmid17139167
doi10.1159/000097623
tpages6