schliessen

Filtern

 

Bibliotheken

Cover Image

An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer

Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association b... Full description

Journal Title: Digestion 2007-02, Vol.74 (2), p.85-90
Main Author: Tang, Li Ping
Other Authors: Cho, Chi Hin , Hui, Wai Mo , Huang, Camy , Chu, Kent Man , Xia, Harry H.X , Lam, Shiu Kum , Rashid, Asif , Wong, Benjamin C.Y , Chan, Annie On On
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis Regulatory Proteins - genetics
Cadherins - genetics
Calcium-Calmodulin-Dependent Protein Kinases - genetics
CpG Islands - genetics
Death-Associated Protein Kinases
DNA Methylation
DNA Modification Methylases
DNA Repair Enzymes
Female
Gene Expression Regulation, Neoplastic
Genes, p16
Genes, Tumor Suppressor
Humans
Interleukin-6 - blood
Male
Middle Aged
Neoplasm Staging
Original Paper
Prognosis
Promoter Regions, Genetic - genetics
Stomach Neoplasms - diagnosis
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Tumor Suppressor Protein p14ARF - genetics
Tumor Suppressor Proteins
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 0012-2823
Link: https://www.ncbi.nlm.nih.gov/pubmed/17139167
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmed_primary_17139167
title: An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
format: Article
creator:
  • Tang, Li Ping
  • Cho, Chi Hin
  • Hui, Wai Mo
  • Huang, Camy
  • Chu, Kent Man
  • Xia, Harry H.X
  • Lam, Shiu Kum
  • Rashid, Asif
  • Wong, Benjamin C.Y
  • Chan, Annie On On
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Apoptosis Regulatory Proteins - genetics
  • Cadherins - genetics
  • Calcium-Calmodulin-Dependent Protein Kinases - genetics
  • CpG Islands - genetics
  • Death-Associated Protein Kinases
  • DNA Methylation
  • DNA Modification Methylases
  • DNA Repair Enzymes
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genes, p16
  • Genes, Tumor Suppressor
  • Humans
  • Interleukin-6 - blood
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Original Paper
  • Prognosis
  • Promoter Regions, Genetic - genetics
  • Stomach Neoplasms - diagnosis
  • Stomach Neoplasms - mortality
  • Stomach Neoplasms - pathology
  • Tumor Suppressor Protein p14ARF - genetics
  • Tumor Suppressor Proteins
ispartof: Digestion, 2007-02, Vol.74 (2), p.85-90
description: Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0012-2823
fulltext: fulltext
issn:
  • 0012-2823
  • 1421-9867
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.1132922
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmed_primary_17139167
sourceformatXML
sourcesystemPC
sourcerecordid68309072
originalsourceidFETCH-LOGICAL-c322t-82bd6b18fe64a0b4d84ea44cda067f47c73fec10907800d3dbd9d8a93ad3afff3
addsrcrecordideNqF0c9LHDEUB_AgLXXVHvwHSuih4GHalx-bH0fZ1nXBUsH2PGSSN3V0NqNJpuJ_3xlcFLyYSxLyeY8XvoQcM_jK2NJ-g2lZrbjYIwsmOausUfodWQAwXnHDxT45yPlmvlopPpB9ppmwTOkFuT-NdBP_YcpIV0NK2LvSDZE2WB4Q57eCqcfxtouVoi4GeoU9-kLXGJFepmE7TID-xHL9uCvtIr2cThhLpg9duaZrl0vqPF256DEdkfet6zN-3O2H5M_Zj9-r8-ri13qzOr2ovOC8VIY3QTXMtKikg0YGI9FJ6YMDpVupvRYtegYWtAEIIjTBBuOscEG4tm3FIfny1PcuDfcj5lJvu-yx713EYcy1MmIu5m9CPjFu2Aw_v4I3w5ji9Ima2SWzwqgZnTwhn4acE7b1Xeq2Lj3WDOo5rfo5rcl-2jUcmy2GF7mL52W0W5f-YnoG3zdrDqBASwAOZin-A5P7mtE
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid195193862
display
typearticle
titleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
sourceAlma/SFX Local Collection
creatorTang, Li Ping ; Cho, Chi Hin ; Hui, Wai Mo ; Huang, Camy ; Chu, Kent Man ; Xia, Harry H.X ; Lam, Shiu Kum ; Rashid, Asif ; Wong, Benjamin C.Y ; Chan, Annie On On
creatorcontribTang, Li Ping ; Cho, Chi Hin ; Hui, Wai Mo ; Huang, Camy ; Chu, Kent Man ; Xia, Harry H.X ; Lam, Shiu Kum ; Rashid, Asif ; Wong, Benjamin C.Y ; Chan, Annie On On
descriptionBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
identifier
0ISSN: 0012-2823
1EISSN: 1421-9867
2DOI: 10.1159/000097623
3PMID: 17139167
4CODEN: DIGEBW
languageeng
publisherBasel, Switzerland: S. Karger AG
subjectAdult ; Aged ; Aged, 80 and over ; Apoptosis Regulatory Proteins - genetics ; Cadherins - genetics ; Calcium-Calmodulin-Dependent Protein Kinases - genetics ; CpG Islands - genetics ; Death-Associated Protein Kinases ; DNA Methylation ; DNA Modification Methylases ; DNA Repair Enzymes ; Female ; Gene Expression Regulation, Neoplastic ; Genes, p16 ; Genes, Tumor Suppressor ; Humans ; Interleukin-6 - blood ; Male ; Middle Aged ; Neoplasm Staging ; Original Paper ; Prognosis ; Promoter Regions, Genetic - genetics ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Tumor Suppressor Protein p14ARF - genetics ; Tumor Suppressor Proteins
ispartofDigestion, 2007-02, Vol.74 (2), p.85-90
rights2006 S. Karger AG, Basel
lds50peer_reviewed
citesFETCH-LOGICAL-c322t-82bd6b18fe64a0b4d84ea44cda067f47c73fec10907800d3dbd9d8a93ad3afff3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17139167$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Tang, Li Ping
1Cho, Chi Hin
2Hui, Wai Mo
3Huang, Camy
4Chu, Kent Man
5Xia, Harry H.X
6Lam, Shiu Kum
7Rashid, Asif
8Wong, Benjamin C.Y
9Chan, Annie On On
title
0An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
1Digestion
addtitleDigestion
descriptionBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
subject
0Adult
1Aged
2Aged, 80 and over
3Apoptosis Regulatory Proteins - genetics
4Cadherins - genetics
5Calcium-Calmodulin-Dependent Protein Kinases - genetics
6CpG Islands - genetics
7Death-Associated Protein Kinases
8DNA Methylation
9DNA Modification Methylases
10DNA Repair Enzymes
11Female
12Gene Expression Regulation, Neoplastic
13Genes, p16
14Genes, Tumor Suppressor
15Humans
16Interleukin-6 - blood
17Male
18Middle Aged
19Neoplasm Staging
20Original Paper
21Prognosis
22Promoter Regions, Genetic - genetics
23Stomach Neoplasms - diagnosis
24Stomach Neoplasms - mortality
25Stomach Neoplasms - pathology
26Tumor Suppressor Protein p14ARF - genetics
27Tumor Suppressor Proteins
issn
00012-2823
11421-9867
fulltexttrue
rsrctypearticle
creationdate2007
recordtypearticle
recordideNqF0c9LHDEUB_AgLXXVHvwHSuih4GHalx-bH0fZ1nXBUsH2PGSSN3V0NqNJpuJ_3xlcFLyYSxLyeY8XvoQcM_jK2NJ-g2lZrbjYIwsmOausUfodWQAwXnHDxT45yPlmvlopPpB9ppmwTOkFuT-NdBP_YcpIV0NK2LvSDZE2WB4Q57eCqcfxtouVoi4GeoU9-kLXGJFepmE7TID-xHL9uCvtIr2cThhLpg9duaZrl0vqPF256DEdkfet6zN-3O2H5M_Zj9-r8-ri13qzOr2ovOC8VIY3QTXMtKikg0YGI9FJ6YMDpVupvRYtegYWtAEIIjTBBuOscEG4tm3FIfny1PcuDfcj5lJvu-yx713EYcy1MmIu5m9CPjFu2Aw_v4I3w5ji9Ima2SWzwqgZnTwhn4acE7b1Xeq2Lj3WDOo5rfo5rcl-2jUcmy2GF7mL52W0W5f-YnoG3zdrDqBASwAOZin-A5P7mtE
startdate200702
enddate200702
creator
0Tang, Li Ping
1Cho, Chi Hin
2Hui, Wai Mo
3Huang, Camy
4Chu, Kent Man
5Xia, Harry H.X
6Lam, Shiu Kum
7Rashid, Asif
8Wong, Benjamin C.Y
9Chan, Annie On On
generalS. Karger AG
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97QP
107X7
117XB
1288E
138AO
148FI
158FJ
168FK
17ABUWG
18BENPR
19FYUFA
20GHDGH
21K9.
22M0S
23M1P
24PQEST
25PQQKQ
26PQUKI
27PRINS
28S0X
297T5
307TM
318FD
32FR3
33H94
34P64
35RC3
367X8
sort
creationdate200702
titleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
authorTang, Li Ping ; Cho, Chi Hin ; Hui, Wai Mo ; Huang, Camy ; Chu, Kent Man ; Xia, Harry H.X ; Lam, Shiu Kum ; Rashid, Asif ; Wong, Benjamin C.Y ; Chan, Annie On On
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c322t-82bd6b18fe64a0b4d84ea44cda067f47c73fec10907800d3dbd9d8a93ad3afff3
rsrctypearticles
prefilterarticles
languageeng
creationdate2007
topic
0Adult
1Aged
2Aged, 80 and over
3Apoptosis Regulatory Proteins - genetics
4Cadherins - genetics
5Calcium-Calmodulin-Dependent Protein Kinases - genetics
6CpG Islands - genetics
7Death-Associated Protein Kinases
8DNA Methylation
9DNA Modification Methylases
10DNA Repair Enzymes
11Female
12Gene Expression Regulation, Neoplastic
13Genes, p16
14Genes, Tumor Suppressor
15Humans
16Interleukin-6 - blood
17Male
18Middle Aged
19Neoplasm Staging
20Original Paper
21Prognosis
22Promoter Regions, Genetic - genetics
23Stomach Neoplasms - diagnosis
24Stomach Neoplasms - mortality
25Stomach Neoplasms - pathology
26Tumor Suppressor Protein p14ARF - genetics
27Tumor Suppressor Proteins
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Tang, Li Ping
1Cho, Chi Hin
2Hui, Wai Mo
3Huang, Camy
4Chu, Kent Man
5Xia, Harry H.X
6Lam, Shiu Kum
7Rashid, Asif
8Wong, Benjamin C.Y
9Chan, Annie On On
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Calcium & Calcified Tissue Abstracts
9Health & Medical Collection
10ProQuest Central (purchase pre-March 2016)
11Medical Database (Alumni Edition)
12ProQuest Pharma Collection
13Hospital Premium Collection
14Hospital Premium Collection (Alumni Edition)
15ProQuest Central (Alumni) (purchase pre-March 2016)
16ProQuest Central (Alumni Edition)
17ProQuest Central
18Health Research Premium Collection
19Health Research Premium Collection (Alumni)
20ProQuest Health & Medical Complete (Alumni)
21Health & Medical Collection (Alumni Edition)
22Medical Database
23ProQuest One Academic Eastern Edition
24ProQuest One Academic
25ProQuest One Academic UKI Edition
26ProQuest Central China
27SIRS Editorial
28Immunology Abstracts
29Nucleic Acids Abstracts
30Technology Research Database
31Engineering Research Database
32AIDS and Cancer Research Abstracts
33Biotechnology and BioEngineering Abstracts
34Genetics Abstracts
35MEDLINE - Academic
jtitleDigestion
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Tang, Li Ping
1Cho, Chi Hin
2Hui, Wai Mo
3Huang, Camy
4Chu, Kent Man
5Xia, Harry H.X
6Lam, Shiu Kum
7Rashid, Asif
8Wong, Benjamin C.Y
9Chan, Annie On On
formatjournal
genrearticle
ristypeJOUR
atitleAn Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer
jtitleDigestion
addtitleDigestion
date2007-02
risdate2007
volume74
issue2
spage85
epage90
pages85-90
issn0012-2823
eissn1421-9867
codenDIGEBW
abstractBackground: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer.
copBasel, Switzerland
pubS. Karger AG
pmid17139167
doi10.1159/000097623
tpages6