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Effect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea

Background: Elevated nasal resistance and obesity predispose to obstructive sleep apnea (OSA). Weight loss has been shown to result in an alleviation of OSA, but its effect on nasal airflow has not been studied. Methods: This study was a prospective, randomized, controlled study with two parallel gr... Full description

Journal Title: American journal of rhinology 2008-07, Vol.22 (4), p.410-415
Main Author: Kemppainen, Tatu
Other Authors: Ruoppi, Pirkko , Seppa, Juha , Sahlman, Johanna , Peltonen, Markku , Tukiainen, Hannu , Gylling, Helena , Vanninen, Esko , Tuomilehto, Henri
Format: Electronic Article Electronic Article
Language: English
Subjects:
Acoustic rhinometry
Adolescent
Adult
Aged
Airway Resistance - physiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
nasal obstruction
obesity
Overweight - complications
Overweight - physiopathology
Overweight - therapy
Prognosis
Prospective Studies
Quality of Life
rhinomanometry
Rhinomanometry - methods
rhinometry
Rhinometry, Acoustic - methods
Severity of Illness Index
sleep apnea
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - therapy
Surveys and Questionnaires
weight loss
Weight Loss - physiology
Publisher: United States: OceanSide Publications, Inc
ID: ISSN: 1050-6586
Link: https://www.ncbi.nlm.nih.gov/pubmed/18702908
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recordid: cdi_pubmed_primary_18702908
title: Effect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea
format: Article
creator:
  • Kemppainen, Tatu
  • Ruoppi, Pirkko
  • Seppa, Juha
  • Sahlman, Johanna
  • Peltonen, Markku
  • Tukiainen, Hannu
  • Gylling, Helena
  • Vanninen, Esko
  • Tuomilehto, Henri
subjects:
  • Acoustic rhinometry
  • Adolescent
  • Adult
  • Aged
  • Airway Resistance - physiology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • nasal obstruction
  • obesity
  • Overweight - complications
  • Overweight - physiopathology
  • Overweight - therapy
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • rhinomanometry
  • Rhinomanometry - methods
  • rhinometry
  • Rhinometry, Acoustic - methods
  • Severity of Illness Index
  • sleep apnea
  • Sleep Apnea, Obstructive - complications
  • Sleep Apnea, Obstructive - physiopathology
  • Sleep Apnea, Obstructive - therapy
  • Surveys and Questionnaires
  • weight loss
  • Weight Loss - physiology
ispartof: American journal of rhinology, 2008-07, Vol.22 (4), p.410-415
description: Background: Elevated nasal resistance and obesity predispose to obstructive sleep apnea (OSA). Weight loss has been shown to result in an alleviation of OSA, but its effect on nasal airflow has not been studied. Methods: This study was a prospective, randomized, controlled study with two parallel groups. A total of 52 adult overweight patients (body mass index [BMI], 28-40 kg/m2) with mild obstructive sleep apnea (apnea-hypopnea index {AHI}, 5-15) were randomized into two study groups. The intervention group (n = 26) followed a very low calorie diet with a supervised lifestyle intervention while the control group (n = 26) received routine lifestyle counseling. The changes in BMI, total nasal resistance, total nasal volume, and quality of life scores (Mini Rhinoconjunctivitis Quality of Life Questionnaire, MiniRQLQ) were assessed at baseline and after the intervention at 3 months. Results: The reduction in BMI in the intervention group was significantly greater than that achieved by patients in the control group (5.4 kg/m2 versus 0.5 kg/m2). Accordingly, AHI was reduced by 3.2 events/hour in the intervention group and by 1.3 in the control group. However, there were no significant changes in rhinometric measurements despite significant weight loss. There was no correlation between the reduction of BMI and the change in nasal resistance or MiniRQLQ scores. Conclusion: Weight reduction does not seem to have any effect on nasal resistance or volume in overweight patients with mild OSA. Patients with OSA and impaired nasal breathing need specific medical or surgical treatment to restore nasal airflow.
language: eng
source:
identifier: ISSN: 1050-6586
fulltext: no_fulltext
issn:
  • 1050-6586
  • 1539-6290
url: Link


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titleEffect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea
creatorKemppainen, Tatu ; Ruoppi, Pirkko ; Seppa, Juha ; Sahlman, Johanna ; Peltonen, Markku ; Tukiainen, Hannu ; Gylling, Helena ; Vanninen, Esko ; Tuomilehto, Henri
creatorcontribKemppainen, Tatu ; Ruoppi, Pirkko ; Seppa, Juha ; Sahlman, Johanna ; Peltonen, Markku ; Tukiainen, Hannu ; Gylling, Helena ; Vanninen, Esko ; Tuomilehto, Henri
descriptionBackground: Elevated nasal resistance and obesity predispose to obstructive sleep apnea (OSA). Weight loss has been shown to result in an alleviation of OSA, but its effect on nasal airflow has not been studied. Methods: This study was a prospective, randomized, controlled study with two parallel groups. A total of 52 adult overweight patients (body mass index [BMI], 28-40 kg/m2) with mild obstructive sleep apnea (apnea-hypopnea index {AHI}, 5-15) were randomized into two study groups. The intervention group (n = 26) followed a very low calorie diet with a supervised lifestyle intervention while the control group (n = 26) received routine lifestyle counseling. The changes in BMI, total nasal resistance, total nasal volume, and quality of life scores (Mini Rhinoconjunctivitis Quality of Life Questionnaire, MiniRQLQ) were assessed at baseline and after the intervention at 3 months. Results: The reduction in BMI in the intervention group was significantly greater than that achieved by patients in the control group (5.4 kg/m2 versus 0.5 kg/m2). Accordingly, AHI was reduced by 3.2 events/hour in the intervention group and by 1.3 in the control group. However, there were no significant changes in rhinometric measurements despite significant weight loss. There was no correlation between the reduction of BMI and the change in nasal resistance or MiniRQLQ scores. Conclusion: Weight reduction does not seem to have any effect on nasal resistance or volume in overweight patients with mild OSA. Patients with OSA and impaired nasal breathing need specific medical or surgical treatment to restore nasal airflow.
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languageeng
publisherUnited States: OceanSide Publications, Inc
subjectAcoustic rhinometry ; Adolescent ; Adult ; Aged ; Airway Resistance - physiology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; nasal obstruction ; obesity ; Overweight - complications ; Overweight - physiopathology ; Overweight - therapy ; Prognosis ; Prospective Studies ; Quality of Life ; rhinomanometry ; Rhinomanometry - methods ; rhinometry ; Rhinometry, Acoustic - methods ; Severity of Illness Index ; sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Sleep Apnea, Obstructive - therapy ; Surveys and Questionnaires ; weight loss ; Weight Loss - physiology
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1Ruoppi, Pirkko
2Seppa, Juha
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8Tuomilehto, Henri
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0Effect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea
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descriptionBackground: Elevated nasal resistance and obesity predispose to obstructive sleep apnea (OSA). Weight loss has been shown to result in an alleviation of OSA, but its effect on nasal airflow has not been studied. Methods: This study was a prospective, randomized, controlled study with two parallel groups. A total of 52 adult overweight patients (body mass index [BMI], 28-40 kg/m2) with mild obstructive sleep apnea (apnea-hypopnea index {AHI}, 5-15) were randomized into two study groups. The intervention group (n = 26) followed a very low calorie diet with a supervised lifestyle intervention while the control group (n = 26) received routine lifestyle counseling. The changes in BMI, total nasal resistance, total nasal volume, and quality of life scores (Mini Rhinoconjunctivitis Quality of Life Questionnaire, MiniRQLQ) were assessed at baseline and after the intervention at 3 months. Results: The reduction in BMI in the intervention group was significantly greater than that achieved by patients in the control group (5.4 kg/m2 versus 0.5 kg/m2). Accordingly, AHI was reduced by 3.2 events/hour in the intervention group and by 1.3 in the control group. However, there were no significant changes in rhinometric measurements despite significant weight loss. There was no correlation between the reduction of BMI and the change in nasal resistance or MiniRQLQ scores. Conclusion: Weight reduction does not seem to have any effect on nasal resistance or volume in overweight patients with mild OSA. Patients with OSA and impaired nasal breathing need specific medical or surgical treatment to restore nasal airflow.
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1Adolescent
2Adult
3Aged
4Airway Resistance - physiology
5Female
6Follow-Up Studies
7Humans
8Male
9Middle Aged
10nasal obstruction
11obesity
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13Overweight - physiopathology
14Overweight - therapy
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16Prospective Studies
17Quality of Life
18rhinomanometry
19Rhinomanometry - methods
20rhinometry
21Rhinometry, Acoustic - methods
22Severity of Illness Index
23sleep apnea
24Sleep Apnea, Obstructive - complications
25Sleep Apnea, Obstructive - physiopathology
26Sleep Apnea, Obstructive - therapy
27Surveys and Questionnaires
28weight loss
29Weight Loss - physiology
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titleEffect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea
authorKemppainen, Tatu ; Ruoppi, Pirkko ; Seppa, Juha ; Sahlman, Johanna ; Peltonen, Markku ; Tukiainen, Hannu ; Gylling, Helena ; Vanninen, Esko ; Tuomilehto, Henri
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0Acoustic rhinometry
1Adolescent
2Adult
3Aged
4Airway Resistance - physiology
5Female
6Follow-Up Studies
7Humans
8Male
9Middle Aged
10nasal obstruction
11obesity
12Overweight - complications
13Overweight - physiopathology
14Overweight - therapy
15Prognosis
16Prospective Studies
17Quality of Life
18rhinomanometry
19Rhinomanometry - methods
20rhinometry
21Rhinometry, Acoustic - methods
22Severity of Illness Index
23sleep apnea
24Sleep Apnea, Obstructive - complications
25Sleep Apnea, Obstructive - physiopathology
26Sleep Apnea, Obstructive - therapy
27Surveys and Questionnaires
28weight loss
29Weight Loss - physiology
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1Ruoppi, Pirkko
2Seppa, Juha
3Sahlman, Johanna
4Peltonen, Markku
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8Tuomilehto, Henri
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1Ruoppi, Pirkko
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atitleEffect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea
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date2008-07
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volume22
issue4
spage410
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pages410-415
issn1050-6586
eissn1539-6290
abstractBackground: Elevated nasal resistance and obesity predispose to obstructive sleep apnea (OSA). Weight loss has been shown to result in an alleviation of OSA, but its effect on nasal airflow has not been studied. Methods: This study was a prospective, randomized, controlled study with two parallel groups. A total of 52 adult overweight patients (body mass index [BMI], 28-40 kg/m2) with mild obstructive sleep apnea (apnea-hypopnea index {AHI}, 5-15) were randomized into two study groups. The intervention group (n = 26) followed a very low calorie diet with a supervised lifestyle intervention while the control group (n = 26) received routine lifestyle counseling. The changes in BMI, total nasal resistance, total nasal volume, and quality of life scores (Mini Rhinoconjunctivitis Quality of Life Questionnaire, MiniRQLQ) were assessed at baseline and after the intervention at 3 months. Results: The reduction in BMI in the intervention group was significantly greater than that achieved by patients in the control group (5.4 kg/m2 versus 0.5 kg/m2). Accordingly, AHI was reduced by 3.2 events/hour in the intervention group and by 1.3 in the control group. However, there were no significant changes in rhinometric measurements despite significant weight loss. There was no correlation between the reduction of BMI and the change in nasal resistance or MiniRQLQ scores. Conclusion: Weight reduction does not seem to have any effect on nasal resistance or volume in overweight patients with mild OSA. Patients with OSA and impaired nasal breathing need specific medical or surgical treatment to restore nasal airflow.
copUnited States
pubOceanSide Publications, Inc
pmid18702908
doi10.2500/ajr.2008.22.3203